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Establishment of test method to detect developmental disorders in juvenile animal models by environmental factors

Research Project

Project/Area Number 18H03036
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionUniversity of Tsukuba

Principal Investigator

Tohyama Chiharu  筑波大学, 医学医療系, 客員教授 (10150872)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords認知行動試験 / 幼若期マウス / 高次脳機能 / 発達神経毒性 / リスク評価 / 安全性評価 / 幼若期マウス行動試験 / 全自動行動試験 / 環境リスク評価 / 行動柔軟性 / 行動試験 / 脳発達
Outline of Final Research Achievements

Hazardous chemicals in food and the environment may disturb the infant's brain's natural growth and development. In order to detect the subtle alterations and elucidate the toxicity mechanisms, we aimed to establish behavioral tests for juvenile mice. To this end, we established the hardware and its test protocol by improving the automated cognitive behavioral assay system, IntelliCage, initially developed for adult mice. Consequently, we enabled, for the first time, to evaluate the cognitive behavior of mice 3-week-old and older. Next, we found atypical behaviors in juvenile mice born to methyl-mercury exposed dams and confirmed the applicability of the toxicity evaluation test system.

Academic Significance and Societal Importance of the Research Achievements

離乳直後の幼若期モデル動物を対象として、化学物質へのばく露に起因する行動変容を検出し、発達途上の脳や末梢組織において生じている異常状態を解明するための新たな学術的研究アプローチが可能となった。確立した認知行動試験は、全自動で実施することができるため、実験の効率性を飛躍的に高めることができる。この手法は、その新規性、効率性から、今後毒性学のみならず、神経科学や精神医学等、様々な生物医学研究分野に応用され、広く社会にその成果が還元されることが期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (7 results)

All 2021 2020 2019 Other

All Int'l Joint Research (1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] University of Zurich(スイス)

    • Related Report
      2019 Annual Research Report
  • [Presentation] 幼若期マウスの全自動認知行動毒性試験法の確立2021

    • Author(s)
      遠藤俊裕、前川文彦、遠山千春
    • Organizer
      第48回日本毒性学会学術年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of an automated cognitive behavioral testing method for juvenile mice in a group-housed environment and its application to developmental neurotoxicological study2021

    • Author(s)
      Toshihiro Endo, Fumihiko Maekawa, Chiharu Tohyama
    • Organizer
      EUROTOX 20212021
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of an automated neurotoxicological assay in juvenile mice2020

    • Author(s)
      Toshihiro ENDO, Seico BENNER, Hans-Peter LIPP
    • Organizer
      Society of Toxicology 59 th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「個性」はいつ現れるか?:離乳後からの全成長過程を追うマウス高次脳機能 試験系の確立2019

    • Author(s)
      遠藤 俊裕、ベナー 聖子、遠山 千春
    • Organizer
      第8回日本DOHaD学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 幼若期マウスにおける集団飼育ホームケージ環境下全自動認知行動試験法の確立2019

    • Author(s)
      遠藤 俊裕、ベナー 聖子、Hans-Peter LIPP、遠山 千春
    • Organizer
      第49回日本神経精神薬理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Automated Cognitive Assay for Juvenile Mice:An application to a mixed-sex colony of C57BL/6N strain in IntelliCage2019

    • Author(s)
      Toshihiro ENDO, Seico BENNER, Hans-Peter LIPP, Chiharu TOHYAMA
    • Organizer
      第6回アジア神経精神薬理学会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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