Clarification of the role of DAMP in health effects caused by particulate matters and risk assessment
| Project/Area Number |
18H03038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | University of Fukui |
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Principal Investigator |
Hiraku Yusuke 福井大学, 学術研究院医学系部門, 教授 (30324510)
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| Co-Investigator(Kenkyū-buntansha) |
田中 昭代 九州大学, 医学研究院, 講師 (10136484)
村田 真理子 三重大学, 医学系研究科, 教授 (10171141)
中野 真規子 慶應義塾大学, 医学部(信濃町), 講師 (70384906)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 粒子状物質 / 炎症 / DAMP / インジウム / リスク評価 |
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| Outline of Final Research Achievements |
Particulate matters are accumulated in the respiratory systems by inhalation exposure and induce chronic inflammation, leading to carcinogenesis and fibrosis. DAMPs include molecules that are released from damaged cells to mediate inflammatory responses, such as HMGB1 and S100 family proteins. This study provided a new mechanism by which indium compounds induce DNA damage in human lung epithelial cells via the release of HMGB1 from exposed cells and inflammatory responses in neighboring cells. In lung tissues of indium-exposed rats, the expression levels of S100 family proteins were dramatically elevated. In workers with past indium exposure, serum indium and KL-6 levels remain to be high, raising concerns about the risk of lung carcinogenesis in the future. DAMP, including HMGB1 and S100 family proteins, may be used for evaluation of the risk of diseases caused by particulate matters.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、我々の実験研究により報告した粒子状物質による健康障害の新規分子機構に基づき、炎症反応に重要な役割を果たすDAMPに注目して、従来と全く異なる発想に基づくバイオマーカーの開発を目指す点に学術的意義および社会的意義がある。また、基礎研究および疫学研究の成果を基盤として、ヒト集団における産業化学物質による健康影響のリスク評価に発展させ、労働者の健康管理に寄与する点に創造性がある。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Idarubicin, an Anthracycline, Induces Oxidative DNA Damage in the Presence of Copper (II).2020
Author(s)
Mizutani H, Shiga C, Imai M, Ikemura K, Kitamura Y, Ohta K, Miyazawa D, Sakanashi M, Tahira T, Maeda T, Hiraku Y, Kawanishi S.
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Journal Title
Anticancer Research
Volume: 40
Issue: 10
Pages: 5399-5404
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Combination of RERG and ZNF671 methylation rates in ccfDNA: a novel biomarker for screening of nasopharyngeal carcinoma2020
Author(s)
Xu Y, Zhao W, Mo Y, Ma N, Midorikawa K, Kobayashi H, Hiraku Y, Oikawa S, Zhang Z, Huang G, Takeuchi K, Murata M.
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Journal Title
Cancer Sci.
Volume: Epub ahead of prin
Issue: 7
Pages: 2536-2545
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Oxidative DNA damage and apoptosis induced by aclarubicin, an anthracycline: role of hydrogen peroxide and copper.2019
Author(s)
Mizutani H, Hayashi Y, Hashimoto M, Imai M, Ichimaru Y, Kitamura Y, Ikemura K, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S
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Journal Title
Anticancer Res
Volume: 39
Issue: 7
Pages: 3443-3451
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oxidative DNA damage induced by pirarubicin, an anthracycline anticancer agent, in the presence of copper(II).2018
Author(s)
Mizutani H, Nishimoto A, Hotta S, Ikemura K, Imai M, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S
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Journal Title
Anticancer Research
Volume: 38
Issue: 5
Pages: 2643-2648
DOI
Related Report
Peer Reviewed / Open Access
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