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Development of the examination of genetic polymorphisms to identify high risk patients for pressure ulcer occurence

Research Project

Project/Area Number 18H03068
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58050:Fundamental of nursing-related
Research InstitutionThe University of Tokyo

Principal Investigator

Minematsu Takeo  東京大学, 大学院医学系研究科(医学部), 特任准教授 (00398752)

Co-Investigator(Kenkyū-buntansha) 真田 弘美  東京大学, 大学院医学系研究科(医学部), 教授 (50143920)
仲上 豪二朗  東京大学, 大学院医学系研究科(医学部), 准教授 (70547827)
玉井 奈緒  東京大学, 大学院医学系研究科(医学部), 特任准教授 (80636788)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords褥瘡 / 遺伝子多型 / 一塩基多型 / リスクアセスメント
Outline of Final Research Achievements

This study aimed to identify the genetic factors to the pressure injury. An animal experiment and a clinical study which targeted on 6 genes (HIF1A、VEGFC、 MSTN、PAI1、HSP90AA1, VDR) were conducted.
In the animal experiment, we introduced expression vector or siRNA of six genes followed by pressure loading in the skin. The results indicated that the over-expression or inhibition of these genes resulted in the severer tissue damage of the compressed skin.
In the clinical study, we analyzed the association between eight SNPs of six genes and pressure injuries in the hospitalized older patients. The multiple regression analysis indicated the significant association of VEGFC (rs1485766) and HIF1A (rs11549465) with shallow and deep pressure injuries, respectively.

Academic Significance and Societal Importance of the Research Achievements

褥瘡は、加齢や疾患などの全身要因で脆弱になった皮膚に外力が加わることで発生する。褥瘡対策としては、リスクアセスメント基づいて体圧分散が行われてきたが、最も高機能なエアマットレスを用いても褥瘡発生を避けられない患者が存在するは、組織耐久性に遺伝的個人差が存在することを示唆している。
本研究では、組織耐久性の個人差を規定していると考えられる遺伝的背景としてリンパ管再生に関わるVEGFC (rs1485766) および低酸素下における組織反応を制御するHIF1A (rs11549465))を同定した。この成果は、遺伝的褥瘡リスクを考慮したテーラーメイド褥瘡予防ケアの開発に繋がるものである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (7 results)

All 2021 2020 2019 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross‐sectional study at a long‐term care hospital2021

    • Author(s)
      Tsukatani Toshihiro、Minematsu Takeo、Dai Misako、Tamai Nao、Nakagami Gojiro、Sugama Junko、Takada Chika、Sanada Hiromi
    • Journal Title

      Wound Repair and Regeneration

      Volume: - Issue: 5 Pages: 741-751

    • DOI

      10.1111/wrr.12912

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人高齢者における褥瘡の保有に関連する一塩基多型の探索.2020

    • Author(s)
      峰松健夫,塚谷才弘,冨田早苗,Sofoklis Koudounas,臺美佐子,大貝和裕,須釜淳子,真田弘美.
    • Organizer
      第50回日本創傷治癒学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 日本人高齢患者における褥瘡リスク遺伝子の多型解析:長期療養型病院における横断研究.2020

    • Author(s)
      塚谷才弘,峰松健夫,臺美佐子,玉井奈緒,仲上豪二朗,須釜淳子,高田千嘉,真田弘美.
    • Organizer
      第22回日本褥瘡学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Myostatin-regulated muscle regeneration in compressed rat skin.2019

    • Author(s)
      Minematsu T, Tsunokuni S, Nakai A, Urai T, Tsukatani T, Sanada H.
    • Organizer
      SAWC Spring/WHS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pressure ulcer development in PAI1-overexpressed mice.2019

    • Author(s)
      Tsukatani T, Minematsu T, Tomida S, Koudounas S, Sanada H.
    • Organizer
      APETNA2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 東京大学大学院医学系研究科社会連携講座スキンケアサイエンス

    • URL

      http://skincarescience.m.u-tokyo.ac.jp/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 社会連携講座スキンケアサイエンス

    • URL

      http://skincarescience.m.u-tokyo.ac.jp/index.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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