Discovery of drug seeds and therapeutic exercises for the purpose of prevention of progression in cancer sarcopenia
| Project/Area Number |
18H03127
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Nagoya University |
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Principal Investigator |
Sugiura Hideshi 名古屋大学, 医学系研究科(保健), 教授 (50303615)
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| Co-Investigator(Kenkyū-buntansha) |
亀高 諭 名古屋大学, 医学系研究科(保健), 教授 (10303950)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | がん / サルコペニア / 運動療法 / 薬剤シーズ / 重症化予防 |
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| Outline of Final Research Achievements |
In a screening of 114 compounds involved in the phenomenon of myoblast fusion using the myoblast fusion assay system (HiMy assay), drug A was found as a potential hit compound that could promote myogenic differentiation of C2C12 mouse myoblasts.There was a trend toward increased skeletal muscle weight in the groups of carcinoma-bearing mice treated with aerobic exercise or aerobic exercise plus Drug A. In particular, there was a significant increase in adiponectin expression in the group treated with aerobic exercise plus Drug A. Clinical studies showed that the amount of physical activity had an impact on postoperative complication rates and postoperative recovery in perioperative cancer patients. The study also showed that exercise therapy significantly improved physical function up to 4 weeks later in terminal cancer patients.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究はがん患者のサルコペニアに対する重症化予防法を目的とした基礎と臨床を往還したアプローチの研究である。基礎研究において筋芽細胞の筋分化を促進する可能性のあるヒット化合物として薬剤Aが見出され、運動療法との相乗効果が期待できると考えられた。臨床研究においてもステージの異なるがん患者に対して運動療法効果が期待できることが確認された。運動療法と薬物療法の両面からアプローチした新たな治療法に繋がる研究であり社会的な意義は大きいと考えられる。
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Report
(5 results)
Research Products
(41 results)
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[Presentation] What kinds of muscle parameters are related to the bone speed of sound in girls with typical development?2019
Author(s)
MATSUNAGA Naomichi, SUGIURA Hideshi, ITO Tadashi, NORITAKE Koji, SUGIMURA Misaki, MIZUSAWA Jun, HAMABE Yu, IGUCHI Saki, ITO Yuji, TAMAMOTO Yoshiji, OCHI Nobuhiko
Organizer
ISPRM2019
Related Report
Int'l Joint Research
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