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Effects of genetic polymorphisms on sport related injuries

Research Project

Project/Area Number 18H03155
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionJuntendo University

Principal Investigator

Fuku Noriyuki  順天堂大学, スポーツ健康科学部, 先任准教授 (40392526)

Co-Investigator(Kenkyū-buntansha) 宮地 元彦  早稲田大学, スポーツ科学学術院, 教授 (60229870)
膳法 浩史  東京聖栄大学, 公私立大学の部局等, 講師 (90749285)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywordsスポーツ傷害 / 遺伝子多型 / 疲労骨折 / 靱帯損傷 / 筋損傷 / ゲノムワイド関連解析 / 遺伝率 / アスリート
Outline of Final Research Achievements

Sports related injuries occur due to the influence of genetic factors in addition to environmental factors such as training and diet. In the present study, we performed genome-wide association studies to identify genetic polymorphisms associated with ligament injuries, muscle injuries and fatigue fractures, which are typical examples of sports related injuries. As a result, 797 polymorphisms were identified for fatigue fractures, 219 in muscle injuries and 144 in ligament injuries. In the case of fatigue fracture, the most strongly associated genetic polymorphism (P<5.3×10-8) among them was a non-coding region in chromosome 13. Further extensive analysis are needed to conclude these associations.

Academic Significance and Societal Importance of the Research Achievements

「競技力」は、「基礎体力」と「トレーニングで獲得した能力」の総和であり、スポーツ外傷・障害などによるトレーニングからの離脱は競技力に対して負に影響するだけでなく、時として選手生命さえも脅かすことがある。このような背景から、スポーツによる傷害や疾病におよぼす遺伝子多型の解明の重要性が指摘されている。なぜなら、スポーツ傷害・疾病を規定する遺伝子多型の解明は、アスリートにおける競技力の最大化やトレーニング効果の適正化を図れる可能性がある。つまり、遺伝要因を加味した総合的観点からスポーツ外傷・障害予防法を開発し、それを現場において活用することでスポーツ傷害の発生抑制に貢献できる可能性がある。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (20 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 11 results,  Open Access: 11 results) Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Lund University(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Kazan State Medical University(ロシア連邦)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Genetic polymorphisms related to muscular strength and flexibility are associated with artistic gymnastic performance.2023

    • Author(s)
      .Hiroshi Kumagai, Tomoko Kaneko, Yuko Shintake, Eri Miyamoto-Mikami, Hiroyuki Tomita, Makoto Fukuo, Wataru Kawai, Mutsumi Harada, Naoki Kikuchi, Nobuhiro Kamiya, Kosuke Hirata, Hirofumi Zempo, Seiji Maeda, Naokazu Miyamoto, Noriyuki Fuku.
    • Journal Title

      European Journal of Sports Science

      Volume: - Issue: 6 Pages: 955-963

    • DOI

      10.1080/17461391.2022.2078741

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic polymorphisms in <i>CYP19A1</i> and <i>ESR1</i> are associated with serum CK activity after prolonged running in men2022

    • Author(s)
      Kumagai Hiroshi、Miyamoto-Mikami Eri、Takaragawa Mizuki、Kuriki Kiyonori、Goto Chiho、Shibata Kiyoshi、Yamada Norihiro、Hosono Akihiro、Fuku Mizuho、Suzuki Sadao、Fuku Noriyuki
    • Journal Title

      Journal of Applied Physiology

      Volume: 132 Issue: 4 Pages: 966-973

    • DOI

      10.1152/japplphysiol.00374.2021

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic variations associated with non‐contact muscle injuries in sport: A systematic review2021

    • Author(s)
      Lim Tifanny、Santiago Catalina、Pareja‐Galeano Helios、Iturriaga Tamara、Sosa‐Pedreschi Alicia、Fuku Noriyuki、P?rez‐Ruiz Margarita、Yvert Thomas
    • Journal Title

      Scandinavian Journal of Medicine &amp; Science in Sports

      Volume: 31 Issue: 11 Pages: 2014-2032

    • DOI

      10.1111/sms.14020

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic variants within the <i>COL5A1</i> gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan2021

    • Author(s)
      Alvarez-Romero Javier、Laguette Mary-Jessica N.、Seale Kirsten、Jacques Macsue、Voisin Sarah、Hiam Danielle、Feller Julian A.、Tirosh Oren、Miyamoto-Mikami Eri、Kumagai Hiroshi、Kikuchi Naoki、Kamiya Nobuhiro、Fuku Noriyuki、Collins Malcolm、September Alison V.、Eynon Nir
    • Journal Title

      European Journal of Sport Science

      Volume: N/A Issue: 2 Pages: 284-293

    • DOI

      10.1080/17461391.2021.2011426

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A rs936306 C/T Polymorphism in the CYP19A1 Is Associated With Stress Fractures2020

    • Author(s)
      Kumagai Hiroshi、Miyamoto-Mikami Eri、Kikuchi Naoki、Kamiya Nobuhiro、Zempo Hirofumi、Fuku Noriyuki
    • Journal Title

      Journal of Strength and Conditioning Research

      Volume: - Issue: 8 Pages: 2322-2325

    • DOI

      10.1519/jsc.0000000000003825

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secular trends in the grip strength and body mass index of sport university students between 1973 and 20162020

    • Author(s)
      Kidokoro T, Kohmura Y, Fuku N, Someya Y, Suzuki K.
    • Journal Title

      J Exerc Sci Fit

      Volume: 18 Issue: 1 Pages: 21-30

    • DOI

      10.1016/j.jesf.2019.08.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis2020

    • Author(s)
      Semenova EA, Miyamoto-Mikami E, Akimov EB, Al-Khelaifi F, Murakami H, Zempo H, Kostryukova ES, Kulemin NA, Larin AK, Borisov OV, Miyachi M, Popov DV, Boulygina EA, Takaragawa M, Kumagai H, Naito H, Pushkarev VP, Dyatlov DA, Lekontsev EV, Pushkareva YE, Andryushchenko LB, Elrayess MA, Generozov EV, Fuku N, Ahmetov II
    • Journal Title

      European Journal of Applied Physiology

      Volume: 120 Issue: 3 Pages: 665-673

    • DOI

      10.1007/s00421-020-04306-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes.2019

    • Author(s)
      Miyamoto-Mikami E, Miyamoto N, Kumagai H, Hirata K, Kikuchi N, Zempo H, Kimura N, Kamiya N, Kanehisa H, Naito H, Fuku N.
    • Journal Title

      BMC Medical Genetics.

      Volume: 20 Issue: 1 Pages: 192-192

    • DOI

      10.1186/s12881-019-0928-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of genetic polymorphisms in determining muscle fiber type composition in Japanese men and women.2018

    • Author(s)
      Hiroshi Kumagai, Takuro Tobina, Noriko Ichinoseki-Sekine, Ryo Kakigi, Takamasa Tsuzuki, Hirofumi Zempo, Keisuke Shiose, Eiichi Yoshimura, Hideaki Kumahara, Makoto Ayabe, Yasuki Higaki, Ryo Yamada, Hiroyuki Kobayashi, Akira Kiyonaga, Hisashi Naito, Hiroaki Tanaka, Noriyuki Fuku.
    • Journal Title

      Journal of Applied Physiology

      Volume: in press Issue: 3 Pages: 1-11

    • DOI

      10.1152/japplphysiol.00953.2017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AGTR2 and sprint/power performance: a case-control replicationstudy for rs11091046 polymorphism in two ethnicities2018

    • Author(s)
      Yvert TP、Zempo H、Gabdrakhmanova LJ、Kikuchi N、Miyamoto-Mikami E、Murakami H、Naito H、Miyachi M、Fuku N et al.
    • Journal Title

      Biology of Sport

      Volume: - Issue: 2 Pages: 105-109

    • DOI

      10.5114/biolsport.2018.71599

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness2018

    • Author(s)
      Hiroshi Kumagai、Eri Miyamoto-Mikami、Kosuke Hirata、Naoki Kikuchi、Nobuhiro Kamiya、Seigo Hoshikawa、Hirofumi Zempo、Hisashi Naito、Naokazu Miyamoto、Noriyuki Fuku
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 1 Issue: 1 Pages: 19-26

    • DOI

      10.1249/mss.0000000000001750

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The opposite associations of rs1107946 polymorphism in the COL1A1 with fatigue-fracture and muscle injury in Japanese athletes2019

    • Author(s)
      Miyamoto-Mikami E, Kumagai H, Kikuchi N, Kamiya N, Kohmura Y, Suzuki K, Naito H, Miyamoto N, Fuku N
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The association of ACTN3 R577X polymorphism with elite Japanese athlete status by various sport events2019

    • Author(s)
      Nobuhiko Akazawa, Nao Ohiwa, Noriyuki Fuku, Hiroshi Kumagai, Kazuhiro Shimizu, Yasuhiro Suzuki
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 筋線維組成関連遺伝子多型が高血圧発症におよぼす影響の検討-J-Fit+ study-2019

    • Author(s)
      宮本(三上)恵里, 染谷由希, 熊谷仁, 河村剛光, 鈴木宏哉, 内藤久士, 福典之
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アスリートの競技特性が将来の高血圧発症に及ぼす影響-J-Fit+ study-2019

    • Author(s)
      熊谷仁, 染谷由希, 吉岡将輝, 宮本恵里, 崔英珠, 寶川美月, 中村美幸, 河村剛光, 鈴木宏哉, 町田修一, 内藤久士, 前田清司, 福典之
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A Pro-Diabetogenic mtDNA Polymorphism in the Mitochondrial-Derived Peptide, MOTS-c2019

    • Author(s)
      Hirofumi Zempo, Su-Jeong Kim, Noriyuki Fuku et al.
    • Organizer
      Keystone Symposia - New Insight into the Biology of Exercise
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スポーツパフォーマンスに関連する遺伝子多型と生活習慣病との関連2019

    • Author(s)
      福典之
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Funded Workshop] 24th Annual Congress of the European College of Sport Science2019

    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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