Role of Piezo channels in mechanosesing of skeletal muscle cells -Improvement of skeletal muscle function by stimulation of Piezo channels-

• Project/Area Number: 18H03160
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Toyohashi Sozo University
• Principal Investigator: Goto Katsumasa 豊橋創造大学, 保健医療学部, 教授 (70239961)
• Co-Investigator(Kenkyū-buntansha): 鈴木 喜郎 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 助教 (40348503)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: 骨格筋 / 機械的刺激 / チャネル / Ca2+ / Ca2＋

Outline of Final Research Achievements

The purpose of this study was to investigate a physiological role of Piezo channels in the plasticity of skeletal muscle cells. Stretch-induced Ca2+ influx in skeletal muscle cells was partially suppressed by an antagonist of Piezo channels. Agonist-induced stimulation of Piezo channels caused the regrowth of myotubes. Evidences indicate Piezo channels may be a target molecule for not only the stimulation of skeletal muscle hypertrophy but also the suppression of aging-associated muscle atrophy and malfunction, namely sarcopenia.

Academic Significance and Societal Importance of the Research Achievements

健康長寿を目指して運動が推奨されている。一方で、加齢に伴う骨格筋量と機能の低下（サルコペニア）に対する適切な運動処方は確立しておらず、早急に解決が望まれている。サルコペニアは、日常生活活動に大きな変化がなくとも発症し、骨格筋機能と量は低下することが知られている。したがって、運動刺激に対する感受性が低下することが、加齢に伴う骨格筋機能や量の低下を引き起こすことを強く示唆する。本研究により、ピエゾチャネルが骨格筋の機械的刺激を受容することが明らかになったことから、ピエゾチャネルを標的としたサルコペニアの予防と改善の治療戦略の立案へ向けた基礎資料を得た。

Research Products

• [Int'l Joint Research] King's College London(英国)
• [Int'l Joint Research] University of Minnesota Medical School(米国)
• [Int'l Joint Research] University of Minnesota Medical School(米国)
• [Int'l Joint Research] King's College London(英国)
• [Journal Article] Fine-Tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis (2022)
  • Author(s): Ortuste Quiroga Huascar Pedro、Ganassi Massimo、Yokoyama Shingo、Nakamura Kodai、Yamashita Tomohiro、Raimbach Daniel、Hagiwara Arisa、Harrington Oscar、Breach-Teji Jodie、Asakura Atsushi、Suzuki Yoshiro、Tominaga Makoto、Zammit Peter S.、Goto Katsumasa
  • Journal Title: Cells Volume: 11 Issue: 3 Pages: 393-393
  • DOI: 10.3390/cells11030393
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle (2022)
  • Author(s): Egawa Tatsuro、Ogawa Takeshi、Yokokawa Takumi、Kido Kohei、Goto Katsumasa、Hayashi Tatsuya
  • Journal Title: Journal of Applied Physiology Volume: 132 Issue: 2 Pages: 477-488
  • DOI: 10.1152/japplphysiol.00539.2021
  • Peer Reviewed
• [Journal Article] 骨格筋量調整における胃・小腸－骨格筋間の臓器間ネットワークの役割 (2022)
  • Author(s): 後藤勝正
  • Journal Title: BIO Clinica Volume: 37 Pages: 56-59
  • Peer Reviewed
• [Journal Article] MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle (2020)
  • Author(s): Yokoyama Shingo、Ohno Yoshitaka、Egawa Tatsuro、Ohashi Kazuya、Ito Rika、Ortuste Quiroga Huascar Pedro、Yamashita Tomohiro、Goto Katsumasa
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 17 Pages: 6376-6376
  • DOI: 10.3390/ijms21176376
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice (2020)
  • Author(s): Egawa Tatsuro、Kido Kohei、Yokokawa Takumi、Fujibayashi Mami、Goto Katsumasa、Hayashi Tatsuya
  • Journal Title: Acta Astronautica Volume: 176 Pages: 332-340
  • DOI: 10.1016/j.actaastro.2020.07.002
  • Peer Reviewed / Open Access
• [Journal Article] Roles of satellite cells and/or myonuclei in the regulation of morphological properties of anti-gravitational skeletal muscle in response to mechanical stress (2020)
  • Author(s): Ohira Takashi、Kawano Fuminori、Ozaki Yusaku、Fukuda Shunya、Goto Katsumasa、Ohira Yoshinobu
  • Journal Title: Biological Sciences in Space Volume: 34 Issue: 0 Pages: 1-11
  • DOI: 10.2187/bss.34.1
  • NAID: 130007869214
  • ISSN: 0914-9201, 1349-967X
  • Peer Reviewed / Open Access
• [Journal Article] Role of active plantar-flexion and/or passive dorsi-flexion of ankle joints as the countermeasure for unloading-related effects in human soleus (2020)
  • Author(s): Okabe Hirooki、Ohira Takashi、Kawano Fuminori、Ohira Luna、Ohira Tomohiro、Kamibayashi Kiyotaka、Goto Katsumasa、Naito Hisashi、Ohira Yoshinobu
  • Journal Title: Acta Astronautica Volume: 175 Pages: 174-178
  • DOI: 10.1016/j.actaastro.2020.05.057
  • Peer Reviewed / Open Access
• [Journal Article] Role(s) of gravitational loading on the growth and development of neuromuscular propertiesIES (2020)
  • Author(s): Kawano Fuminori、Ohira Takashi、Goto Katsumasa、Ohira Yoshinobu
  • Journal Title: Aerospace and Environmental Medicine Volume: 54 Issue: 6 Pages: 73-79
  • DOI: 10.21687/0233-528x-2020-54-6-73-79
  • Peer Reviewed
• [Journal Article] 筋トレの生化学：筋肥大のメカニズム (2020)
  • Author(s): 後藤勝正
  • Journal Title: 臨床リハビリテーション Volume: 29 Pages: 116-122
• [Journal Article] Lactate stimulates a potential for hypertrophy and regeneration of mouse skeletal muscle (2019)
  • Author(s): Ohno Y, Ando K, Ito T, Suda Y, Matsui Y, Oyama A, Kaneko H, Yokoyama S, Egawa T, Goto K.
  • Journal Title: Nutrients Volume: 11 Issue: 4 Pages: 869-869
  • DOI: 10.3390/nu11040869
  • Peer Reviewed / Open Access
• [Journal Article] MENS-associated increase of muscular protein content via modulation of caveolin-3 and TRIM72 (2019)
  • Author(s): Ohno Y, Egawa T, Yokoyama S, Fujiya H, Sugiura T, Ohira Y, Yoshioka T, Goto K.
  • Journal Title: Physiological Research Volume: 68 Pages: 265-273
  • DOI: 10.33549/physiolres.933992
  • Peer Reviewed / Open Access
• [Journal Article] Impact of different temperature stimuli on the expression of myosin heavy chain isoforms during recovery from bupivacaine-induced muscle injury in rats (2019)
  • Author(s): Shibaguchi, T., Hoshi, M., Yoshihara, T., Naito, H., Goto, K., Yoshioka, T., Sugiura, T.
  • Journal Title: Journal of Applied Physiology Volume: 127 Issue: 1 Pages: 178-189
  • DOI: 10.1152/japplphysiol.00930.2018
  • Peer Reviewed
• [Journal Article] The Protective Effect of Brazilian Propolis against Glycation Stress in Mouse Skeletal Muscle (2019)
  • Author(s): Egawa T, Ohno Y, Yokoyama S, Yokokawa T, Tsuda S, Goto K, Hayashi T.
  • Journal Title: Foods Volume: 8 Issue: 10 Pages: 439-439
  • DOI: 10.3390/foods8100439
  • NAID: 120006766120
  • Peer Reviewed / Open Access
• [Journal Article] Role of 72-kDa Heat Shock Protein in Heat-stimulated Regeneration of Injured Muscle in Rat. (2019)
  • Author(s): Katsuya Kami, Takashi Ohira, Yasuharu Oishi, Takayuki Nakajima, Katsumasa Goto, Yoshinobu Ohira.
  • Journal Title: Journal of Histochemistry & Cytochemistry Volume: 67 Issue: 11 Pages: 791-799
  • DOI: 10.1369/0022155419859861
  • Peer Reviewed
• [Journal Article] 宇宙医学研究からロコモティブシンドロームを解明する (2019)
  • Author(s): 後藤勝正
  • Journal Title: 整形災害外科 Volume: 62 Pages: 763-770
• [Journal Article] Special Issue “Aging and Skeletal Muscle Atrophy” (2018)
  • Author(s): Goto K.、Tanaka K.、Waki H.
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 7 Issue: 4 Pages: 203-203
  • DOI: 10.7600/jpfsm.7.203
  • NAID: 130007406076
  • ISSN: 2186-8123, 2186-8131
  • Year and Date: 2018-07-25
  • Open Access
• [Journal Article] Age-related changes in myostatin expression in rat skeletal muscles (2018)
  • Author(s): Shibaguchi Tsubasa、Maeoka Takeshi、Yoshihara Toshinori、Naito Hisashi、Goto Katsumasa、Yoshioka Toshitada、Sugiura Takao
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 7 Issue: 4 Pages: 221-227
  • DOI: 10.7600/jpfsm.7.221
  • NAID: 130007406080
  • ISSN: 2186-8123, 2186-8131
  • Year and Date: 2018-07-25
  • Peer Reviewed / Open Access
• [Journal Article] The effect of advanced glycation end products on cellular signaling molecules in skeletal muscle (2018)
  • Author(s): Egawa Tatsuro、Ohno Yoshitaka、Yokoyama Shingo、Goto Ayumi、Ito Rika、Hayashi Tatsuya、Goto Katsumasa
  • Journal Title: The Journal of Physical Fitness and Sports Medicine Volume: 7 Issue: 4 Pages: 229-238
  • DOI: 10.7600/jpfsm.7.229
  • NAID: 130007406072
  • ISSN: 2186-8123, 2186-8131
  • Year and Date: 2018-07-25
  • Peer Reviewed / Open Access
• [Journal Article] Lactate increases myotube diameter via activation of MEK/ERK pathway in C2C12 cells (2018)
  • Author(s): Ohno Y.、Oyama A.、Kaneko H.、Egawa T.、Yokoyama S.、Sugiura T.、Ohira Y.、Yoshioka T.、Goto K.
  • Journal Title: Acta Physiologica Volume: 223 Issue: 2
  • DOI: 10.1111/apha.13042
  • Peer Reviewed
• [Journal Article] AMPK Mediates Muscle Mass Change But Not the Transition of Myosin Heavy Chain Isoforms during Unloading and Reloading of Skeletal Muscles in Mice (2018)
  • Author(s): Egawa Tatsuro、Ohno Yoshitaka、Goto Ayumi、Yokoyama Shingo、Hayashi Tatsuya、Goto Katsumasa
  • Journal Title: International Journal of Molecular Sciences Volume: 19 Issue: 10 Pages: 2954-2954
  • DOI: 10.3390/ijms19102954
  • NAID: 120006534581
  • Peer Reviewed / Open Access
• [Journal Article] Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle (2018)
  • Author(s): Ito Rika、Higa Masaki、Goto Ayumi、Aoshima Megumi、Ikuta Akihiro、Ohashi Kazuya、Yokoyama Shingo、Ohno Yoshitaka、Egawa Tatsuro、Miyata Hirofumi、Goto Katsumasa
  • Journal Title: PLOS ONE Volume: 13 Issue: 10 Pages: 0205645-0205645
  • DOI: 10.1371/journal.pone.0205645
  • NAID: 120006559414
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy (2018)
  • Author(s): Toshinori Yoshihara, Takao Sugiura, Nobuyuki Miyaji, Yuki Yamamoto, Tsubasa Shibaguchi, Ryo Kakigi, Hisashi Naito, Katsumasa Goto, Daijiro Ohmori, Toshitada Yoshioka
  • Journal Title: Journal of Zhejiang University SCIENCE B Volume: N/A Issue: 11 Pages: 844-852
  • DOI: 10.1631/jzus.b1800076
  • Peer Reviewed / Open Access
• [Journal Article] Nuclear Accumulation of HSP70 in Mouse Skeletal Muscles in Response to Heat Stress, Aging, and Unloading With or Without Reloading (2018)
  • Author(s): Apostolopoulos Antonios、Nakamura Ayane、Yokoyama Shingo、Aoshima Megumi、Fujimoto Risa、Nakamura Kodai、Ito Rika、Goto Katsumasa
  • Journal Title: Frontiers in Genetics Volume: 9 Pages: 617-617
  • DOI: 10.3389/fgene.2018.00617
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 胃抑制性ペプチドがマウスヒラメ筋の廃用性筋萎縮ならびにミオシン重鎖発現に及ぼす影響 (2021)
  • Author(s): 横山真吾、大橋和也、萩原ありさ、伊藤理香、後藤勝正
  • Organizer: 第76回日本体力医学会大会
• [Presentation] 糖化ストレスによる運動抵抗性誘導－マウスにおける骨格筋肥大の抑制－ (2021)
  • Author(s): 江川達郎、小川岳史、木戸康平、横川拓海、後藤勝正、林達也
  • Organizer: 第76回日本体力医学会大会
• [Presentation] The effect of glycation state on training effect in young male (2020)
  • Author(s): Egawa Tatsuro、Fujibayashi Mami、Ito Rika, Goto Katsumasa、Hayashi Tatsuya
  • Organizer: 第75回日本体力医学会大会
• [Presentation] 微小重力および老化による骨格筋萎縮における糖化ストレス応答の差異 (2020)
  • Author(s): 江川達郎、木戸康平、横川拓海、後藤勝正、林達也
  • Organizer: 第66回日本宇宙航空環境医学会大会
• [Presentation] 廃用性筋萎縮進行におけるRAGEシグナルの関与 (2020)
  • Author(s): 江川達郎、横川拓海、木戸康平、後藤勝正、林達也
  • Organizer: 第93回日本生化学会大会
• [Presentation] The effect of glycation stress on strength-enhancing effect of resistance training in young male (2020)
  • Author(s): Egawa Tatsuro、Fujibayashi Mami、Ito Rika、Goto Katsumasa、Hayashi Tatsuya
  • Organizer: American Society of Physiology (APS) Integrative Physiology of Exercise
  • Int'l Joint Research
• [Presentation] A physiological role of inter-organ network between gastrointestine and skeletal muscle on the regulation of skeletal muscle volume (2019)
  • Author(s): Goto, K., Aoshima, M., Suzuki, T., Kanda, Y., Inagaki, R., Akiyama, K., Yokoyama, S.
  • Organizer: Experimental Biology 2019 (EB2019)
  • Int'l Joint Research
• [Presentation] 持続的なTRPV4チャネルの活性化と不活性化による筋管細胞の適応 (2019)
  • Author(s): 萩原ありさ，山下智大，Ortuste Quiroga, H.P.，伊藤理香，大野善隆，横山真吾，後藤勝正
  • Organizer: 第74回日本体力医学会大会
• [Presentation] 筋細胞の分化におけるHSP70特異的核輸送体Hikeshiの役割 (2019)
  • Author(s): 山下智大，Ortuste Quiroga, H.P.，萩原ありさ，横山真吾，大野善隆，杉浦崇夫，大平充宣，吉岡利忠，後藤勝正
  • Organizer: 第74回日本体力医学会大会
• [Presentation] Some aspects of mechanosensitive ion channels in myogenesis (2019)
  • Author(s): Ortuste Quiroga, H.P., Yamashita, Y., Hagiwara, A., Yokoyama, S., Suzuki, Y., Tominaga, M., Goto, K.
  • Organizer: 第74回日本体力医学会大会
• [Presentation] 自発走運動によるマウス骨格筋適応に対する糖化ストレスの影響 (2019)
  • Author(s): 江川達郎，大野善隆，横山真吾，小川岳史，後藤勝正，林達也
  • Organizer: 第74回日本体力医学会大会
• [Presentation] 長期間の機能的過負荷による筋サテライト細胞と筋タンパク合成シグナルの変化 (2019)
  • Author(s): 杉浦崇夫，森廣壮馬，芝口翼，内藤久士，後藤勝正，吉岡利忠
  • Organizer: 第74回日本体力医学会大会
• [Presentation] Functional properties of a novel mechanosensitive Ca2+-permeable channel in mouse muscle satellite cells (2019)
  • Author(s): Ortuste Quiroga, H.P., Yamashita, T., Hagiwara, A., Yokoyama, S., Suzuki, Y., Tominaga, M., Goto, K.
  • Organizer: Frontiers in Myogenesis, Skeletal Muscle: Development, Regeneration and Disease
  • Int'l Joint Research
• [Presentation] HSP70-specific nuclear transporter Hikeshi in myogenic differentiation (2019)
  • Author(s): Yamashita, T., Ortuste Quiroga, H.P., Hagiwara, A., Yokoyama, S., Ohno, Y., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K.
  • Organizer: Frontiers in Myogenesis, Skeletal Muscle: Development, Regeneration and Disease
  • Int'l Joint Research
• [Presentation] ACL断裂症例のオーダーメイドリハプログラムの実現に向けて（第6報）－筋線維タイプからみた至適な手術日－ (2019)
  • Author(s): 小林哲士，植原健二，木城智，皆川直毅，鈴木智裕，小倉裕司，黒坂光寿，後藤勝正，仁木久照
  • Organizer: 第34回日本整形外科学会基礎学術集会
• [Presentation] 骨格筋由来乳酸による骨格筋量調整に関する基礎的研究 (2019)
  • Author(s): 大野善隆，伊藤貴史，松井佑樹，安藤孝輝，須田陽平，横山真吾，後藤勝正
  • Organizer: 第24回日本基礎理学療法学会学術大会
• [Presentation] 骨格筋細胞可塑性発現におけるTRPV4と機械的刺激の受容 (2019)
  • Author(s): 萩原ありさ，大野善隆，横山真吾，後藤勝正
  • Organizer: 第65回日本宇宙航空環境医学会大会
• [Presentation] 後肢懸垂時に発生する糖化ストレスによるマウスヒラメ筋萎縮への影響 (2019)
  • Author(s): 江川達郎，横川拓海，木戸康平，後藤勝正，林達也
  • Organizer: 第65回日本宇宙航空環境医学会大会
• [Presentation] 乳酸受容体刺激が骨格筋量に及ぼす影響 (2019)
  • Author(s): 大野善隆，須田陽平，安藤孝輝，松井佑樹，伊藤貴史，金子陽加里，大山明子，横山真吾，江川達郎，後藤勝正
  • Organizer: 第24回日本体力医学会東海地方会学術集会
• [Presentation] A possible of gastric inhibitory polypeptide in the regulation of skeletal muscle mass (2019)
  • Author(s): Goto, K., Aoshima, M., Hagiwara, A., Yamashita, T., Ortuste Quiroga, H.P., Yokoyama, S.
  • Organizer: 第97回日本生理学会大会
• [Presentation] MBNL1-associated mitochondrial dysfunction and apoptosis in C2C12 myotubes and mouse skeletal muscle (2019)
  • Author(s): Yokoyama, S., Ohno, Y., Egawa, T., Nakamura, A., Goto, K.
  • Organizer: International Conference on Frailty & Sarcopenia Research 2019 (ICFSR 2019)
  • Int'l Joint Research
• [Presentation] Adiponectin and skeletal muscle - new insights and potential implications (2019)
  • Author(s): Goto, K.
  • Organizer: The 9th FAOPS (Federation of the Asian and Oceanian Physiological Societies) Congress, The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Glycative stress influences skeletal muscle growth and cell growth signaling in mice (2019)
  • Author(s): Egawa, Y.,
  • Organizer: The 9th FAOPS (Federation of the Asian and Oceanian Physiological Societies) Congress, The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research / Invited
• [Presentation] A possible role in linear ubiquitin assembly complex in skeletal muscle cells (2018)
  • Author(s): Goto, K., Nakamura, K., Yokoyama, S.
  • Organizer: Muscle development, regeneration and disease 2018
  • Int'l Joint Research
• [Presentation] Nuclear accumulation of HSP70 protein in mouse skeletal muscles in response to reloading following unloading (2018)
  • Author(s): Goto, K., Apostolopoulus, A., Nakamura, A., Ohira, Y.
  • Organizer: The Life Sciences Meeting 2018, The Symposium combines the 39th Annual International Gravitational Physiology (ISGP) Meeting and the ESA Space meets Health initiative
  • Int'l Joint Research
• [Presentation] A physiological role of gastric inhibitory polypeptide receptor in myogenic differentiation of C2C12 myoblasts (2018)
  • Author(s): Goto, K., Aoshima, M., Suzuki, T., Kanda, Y., Inagaki, R., Akiyama, K., Yokoyama, S.
  • Organizer: 2018 FASEB SRC (Federation of American Societies for Experimental Biology, Science Research Conferences) “Skeletal Muscle Satellite Cells and Regeneration”
  • Int'l Joint Research
• [Presentation] 長期間の抗酸化食摂取と機能的過負荷が筋肥大に及ぼす影響 (2018)
  • Author(s): 杉浦崇夫，芝口翼，宮司進之，内藤久士，後藤勝正，吉岡利忠
  • Organizer: 第73回日本体力医学会大会
• [Presentation] 哺乳類骨格筋細胞におけるHikeshiタンパク質の発現 (2018)
  • Author(s): 山下智大，Huascar Pedro Ortuste Quiroga ，中村晃大，藤本理沙，伊藤理香，横山真吾，大野善隆，大橋和也，杉浦崇夫，大平充宣，吉岡利忠，後藤勝正
  • Organizer: 第73回日本体力医学会大会
• [Presentation] 哺乳類骨格筋細胞の分化におけるHSF2およびHSF4の役割 (2018)
  • Author(s): 藤本理沙，中村晃大，山下智大，Huascar Pedro Ortuste Quiroga，伊藤理香，横山真吾，大野善隆，大橋和也，杉浦崇夫，大平充宣，吉岡利忠，後藤勝正
  • Organizer: 第73回日本体力医学会大会
• [Presentation] 培養骨格筋細胞の増殖と分化における直鎖状ユビキチン鎖リガーゼ複合体LUBACの機能 (2018)
  • Author(s): 中村晃大，藤本理沙，Huascar Pedro Ortuste Quiroga，山下智大，伊藤理香，横山真吾，大野善隆，大橋和也，杉浦崇夫，大平充宣，吉岡利忠，後藤勝正
  • Organizer: 第73回日本体力医学会大会
• [Presentation] Knockdown of HOIL-1L suppresses proliferation and differentiation of C2C12 myoblasts (2018)
  • Author(s): Nakamura, K., Fujimoto, R., Huascar Pedro Ortuste Quiroga1, Yamashita, T , Ito, R., Yokoyama, S., Ohno, Y., Sugiura, T., Ohira, Y., Yoshioka, T. Goto, K.
  • Organizer: The 34th Annual Meeting of the American Society for Gravitational and Space Research (ASGSR)
  • Int'l Joint Research
• [Presentation] Possible role of heat shock transcription factor 4 in differentiation of skeletal muscle cells (2018)
  • Author(s): Fujimoto, R., Nakamura, K., Yamashita, T., Huascar Pedro Ortuste Quiroga1, Ito, R., Yokoyama, S., Ohno, Y., Ohashi, K., Sugiura, T., Ohira, Y., Yoshioka, T. Goto, K.
  • Organizer: The 34th Annual Meeting of the American Society for Gravitational and Space Research (ASGSR)
  • Int'l Joint Research
• [Presentation] 糖化ストレス応答と骨格筋量制御 (2018)
  • Author(s): 江川達郎，後藤勝正，林達也
  • Organizer: 第64回日本宇宙航空環境医学会大会，シンポジウム「抗重力筋活動レベルが筋の発育・発達、萎縮、肥大に及ぼす影響」
  • Invited
• [Presentation] 温熱刺激に対する骨格筋の応答とその生理学的意義 (2018)
  • Author(s): 後藤勝正
  • Organizer: 第64回日本宇宙航空環境医学会大会，シンポジウム「抗重力筋活動レベルが筋の発育・発達、萎縮、肥大に及ぼす影響」
  • Invited
• [Presentation] 宇宙医学研究のスピンオフ－健康長寿社会を支える宇宙医学研究の視点－ (2018)
  • Author(s): 後藤勝正
  • Organizer: 第8回日本航空宇宙精神神経学会
  • Invited
• [Presentation] アディポネクチン受容体の活性化はC2C12筋管細胞およびマウス骨格筋を萎縮させる (2018)
  • Author(s): 伊藤理香，朝倉実生子，江川達郎，大野善隆，横山真吾，中村晃大，藤本理沙，山下智大，Huascar Pedro Ortuste Quiroga，宮田浩文，後藤勝正
  • Organizer: 第82回日本体力医学会中国・四国地方会
• [Presentation] 非荷重空間における筋肉の減少 (2018)
  • Author(s): 後藤勝正
  • Organizer: 第3回日本抗加齢協会フォーラム，テーマ：春・夏・秋・冬のアンチエイジング
  • Invited
• [Presentation] MBNL1発現低下がマウス骨格筋細胞のミトコンドリア膜電位に及ぼす影響 (2018)
  • Author(s): 横山真吾，中村文音，大野善隆，後藤勝正
  • Organizer: 第23回日本基礎理学療法学会学大会
• [Presentation] 乳酸投与がマウス骨格筋量に及ぼす影響 (2018)
  • Author(s): 大野善隆，松井佑樹，須田陽平，伊藤貴文，安藤孝輝，横山真吾，後藤勝正
  • Organizer: 第23回日本基礎理学療法学会学大会
• [Book] The effect of glycation stress in skeletal muscle. In: Psychology and Patho-physiological Outcomes of Eating (2021)
  • Author(s): Egawa Tatsuro、Kido Kohei、Yokokawa Takumi、Fujibayashi Mami、Goto Katsumasa、Hayashi Tatsuya
  • Total Pages: 272
  • Publisher: IntechOpen
• [Remarks] 豊橋創造大学大学院健康科学研究科生体機能学分野 豊橋創造大学保健医療学部 業績
  • URL: http://www.sozo.ac.jp/professor/goto_katsumasa/publications.html