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Needle-type functional brain imaging device with low invasiveness and high sensitivity by laser lift-off process

Research Project

Project/Area Number 18H03519
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Sasagawa Kiyotaka  奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (50392725)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywordsイメージセンサ / 蛍光観察 / 蛍光フィルタ / 生体埋植デバイス / 脳機能計測 / 励起光除去フィルタ
Outline of Final Research Achievements

In this study, we developed a filter for high-sensitivity in-vivo imaging using a bio-implanted image sensor. We have established a method for transferring a hybrid filter consisting of an interference filter and an absorption filter, and succeeded in achieving high excitation light removal performance even with a small and thin image sensor that does not use a lens. Further, in fluorescence observation, it is necessary to remove unnecessary wavelengths from the excitation light. By applying this method to an excitation filter, we have developed a compact fluorescence excitation light source using a micro LED.

Academic Significance and Societal Importance of the Research Achievements

本研究では、転写手法によって吸収フィルタとして機能する樹脂膜上に高品質な干渉フィルタを転写することにより、レンズレス構成のイメージングデバイスで高精細な蛍光画像が取得可能であることを実証した。フィルタを含めたデバイスは、薄型で大面積化にも対応可能である。このような微小デバイスで高感度蛍光観察を可能とすることにより、本研究での主たる研究対象である生体内の観察のみならず、蛍光を応用した様々な計測装置を非常に小型化することが可能になる。これにより、装置の可搬性を大幅に向上し、現場での迅速な計測等に応用できるものと期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (44 results)

All 2021 2020 2019 2018

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results) Presentation (32 results) (of which Int'l Joint Research: 8 results,  Invited: 8 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Image Sensor with Hybirid Emission Filter for <i>in-vivo</i> Fluorescent Imaging2021

    • Author(s)
      笹川 清隆, Erus Rustami, 太田 安美, 春田 牧人, 竹原 浩成, 田代 洋行, 太田 淳,
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 141 Issue: 3 Pages: 71-76

    • DOI

      10.1541/ieejsmas.141.71

    • NAID

      130007993095

    • ISSN
      1341-8939, 1347-5525
    • Year and Date
      2021-03-01
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Image sensor with hybrid emission filter for in vivo fluorescent imaging2021

    • Author(s)
      Sasagawa Kiyotaka、Rustami Erus、Ohta Yasumi、Haruta Makito、Takehara Hironari、Tashiro Hiroyuki、Ohta Jun
    • Journal Title

      Electronics and Communications in Japan

      Volume: - Issue: 2

    • DOI

      10.1002/ecj.12313

    • NAID

      210000167723

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Miniaturized LED light source with an excitation filter for fluorescent imaging2021

    • Author(s)
      Azmer Mohamad Izzat、Sasagawa Kiyotaka、Rustami Erus、Sugie Kenji、Ohta Yasumi、Haruta Makito、Takehara Hironari、Tashiro Hiroyuki、Ohta Jun
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 60 Issue: SB Pages: SBBG07-SBBG07

    • DOI

      10.35848/1347-4065/abe5bf

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Needle-Type Imager Sensor With Band-Pass Composite Emission Filter and Parallel Fiber-Coupled Laser Excitation2020

    • Author(s)
      Rustami Erus、Sasagawa Kiyotaka、Sugie Kenji、Ohta Yasumi、Haruta Makito、Noda Toshihiko、Tokuda Takashi、Ohta Jun
    • Journal Title

      IEEE Transactions on Circuits and Systems I: Regular Papers

      Volume: 67 Issue: 4 Pages: 1082-1091

    • DOI

      10.1109/tcsi.2019.2959592

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An implantable light source for in-vivo fluorescence image sensor2020

    • Author(s)
      Sasagawa Kiyotaka、Rustami Erus、Takehara Hironari、Haruta Makito、Ohta Jun
    • Journal Title

      Proceedings of SPIE

      Volume: 11235 Pages: 31-31

    • DOI

      10.1117/12.2545482

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of thin composite emission filter for high-performance lens-free fluorescent imager2020

    • Author(s)
      Rustami Erus、Sasagawa Kiyotaka、Pakpuwadon Thanet、Ohta Yasumi、Takehara Hironari、Haruta Makito、Ohta Jun
    • Journal Title

      Proceedings of SPIE

      Volume: 11235 Pages: 14-14

    • DOI

      10.1117/12.2546540

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lens-free Dual-color Fluorescent CMOS Image Sensor for F?rster Resonance Energy Transfer Imaging2019

    • Author(s)
      Hee Wan Shen、Sasagawa Kiyotaka、Kameyama Aiki、Kimura Ayaka、Haruta Makito、Tokuda Takashi、Ohta Jun
    • Journal Title

      Sensors and Materials

      Volume: 31 Issue: 8 Pages: 2579

    • DOI

      10.18494/SAM.2019.2358

    • ISSN
      0914-4935, 2435-0869
    • Year and Date
      2019-08-30
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Implantable CMOS image sensor with incident-angle-selective pixels2019

    • Author(s)
      Sugie K.、Sasagawa K.、Guinto M.C.、Haruta M.、Tokuda T.、Ohta J.
    • Journal Title

      Electronics Letters

      Volume: 55 Issue: 13 Pages: 729-731

    • DOI

      10.1049/el.2019.1031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wide field-of-view lensless fluorescence imaging device with hybrid bandpass emission filter2019

    • Author(s)
      K. Sasagawa, Y. Ohta, M. Kawahara, M. Haruta, T. Noda, T. Tokuda, J. Ohta
    • Journal Title

      AIP Advances

      Volume: 9 Issue: 3 Pages: 035108-035108

    • DOI

      10.1063/1.5083152

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly sensitive lens-free fluorescence imaging device enabled by a complementary combination of interference and absorption filters2018

    • Author(s)
      K. Sasagawa, A. Kimura, M. Haruta, T. Noda, T. Tokuda, J. Ohta
    • Journal Title

      Biomedical Optics Express

      Volume: 9 Issue: 9 Pages: 4329-4329

    • DOI

      10.1364/boe.9.004329

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] A self-reset CMOS imaging device with high capacitance photodiode2021

    • Author(s)
      Thanet Pakpuwadon, Kiyotaka Sasagawa, Mark Christian Guinto, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Jun Ohta
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Miniaturized LED light source with a hybrid filter for fluorescent imaging2020

    • Author(s)
      Mohamad Izzat Azmer Adnan, Kiyotaka Sasagawa, Erus Rustami, Kenji Sugie, Yasumi Ohta, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Jun Ohta
    • Organizer
      2020 International Conference on Solid State Devices and Materials(SSDM2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A self-reset CMOS image sensor for high signal-to-noise in-vivo imaging2020

    • Author(s)
      Thanet Pakpuwadon, Mark Guinto Christian, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta
    • Organizer
      2020 International Conference on Solid State Devices and Materials(SSDM2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Image refocusing of miniature CMOS image sensor with angle-selective pixels2020

    • Author(s)
      Kenji Sugie, Kiyotaka Sasagawa, Mark Guinto, Makito Haruta, Takashi Tokuda, Jun Ohta
    • Organizer
      Biophotonics congress 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatial Resolution Improvement of Lensless Fluorescence Imaging Device with Hybrid Emission Filter2020

    • Author(s)
      Kiyotaka Sasagawa, Kenji Sugie, Yasumi Ohta, Mamiko Kawahara, Hironari Takehara, Makito Haruta, Jun Ohta
    • Organizer
      Biophotonics congress 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Hybrid Filters for Dual-color Fluorescence Imaging Using Lens-free Device2020

    • Author(s)
      Kulmala Natcha, Treephetchkul Thanaree, 笹川 清隆, 竹原 浩成, 春田 牧人, 田代 洋行, 太田 淳
    • Organizer
      第37回「センサ・マイクロマシンと応用システム」シンポジウム・第12回集積化MEMSシンポジウム(FT2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] High Rejection of Excitation Light in Lensless Dual-color Fluorescence Imaging Using a Combination of Notch filter and Absorption filters2020

    • Author(s)
      Thanaree Treepetchkul, Natcha Kulmala, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Fabrication of Large-Size and High-Uniformity Thin Composite Emission Filter for Lens-Free Fluorescent Imager2020

    • Author(s)
      Erus Rustami, Kiyotaka Sasagawa, Thanet Pakpuwadon, Yasumi Ohta, Hironari Takehara, Makito Haruta ,Jun Ohta
    • Organizer
      情報センシング研究会 (IST)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Lens-free Imaging Device with Hybrid Emission Filter for Dual-color Fluorescent Imaging2020

    • Author(s)
      Natcha Kulmala, Kiyotaka Sasagawa, Hironari Takehara, Makito Haruta, Jun Ohta
    • Organizer
      第67回応用物理学会春季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Light Source with High Performance Emission Filter for Implantable Fluorescence Imaging Device2020

    • Author(s)
      Mohamad Izzat Azmer, Kiyotaka Sasagawa, Erus Rustami, Yasumi Ohta, Hironari Takehara, Makito Haruta, Jun Ohta
    • Organizer
      第67回応用物理学会春季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脳機能イメージング用角度選択画素搭載CMOSイメージセンサの特性改善2020

    • Author(s)
      杉江 謙治, 笹川 清隆, Guint Mark Guinto, 竹原 浩成, 春田 牧人, 徳田 崇, 太田 淳
    • Organizer
      令和2年電気学会全国大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Implantable Fluorescent CMOS Imaging Device2020

    • Author(s)
      Kiyotaka Sasagawa, Makito Haruta, Yasumi Ohta, Hironari Takehara, Jun Ohta
    • Organizer
      4th IEEE Electron Devices Technology and Manufacturing (EDTM 2020)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lensless Highly Sensitive Fluorescence Imaging2019

    • Author(s)
      Kiyotaka Sasagawa, Kenji Sugie, Yasumi Ohta, Mamiko Kawahara, Makito Haruta, Jun Ohta
    • Organizer
      Biomedical Circuits and Systems Conference 2019(BioCAS2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Band-Pass Emission Filter Combined with Fiber Coupled Laser for High-Performance Implantable Fluorescent Imager"2019

    • Author(s)
      Erus Rustami, Kiyotaka Sasagawa, Yasumi Ohta, Makito Haruta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      10th International Conference on Molecular Electronics & BioElectronics
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lensless fluorescence imaging device with high performance hybrid emission filter2019

    • Author(s)
      Kiyotaka Sasagawa, Yasumi Ohta, Mamiko Kawahara, Makito Haruta, Jun Ohta
    • Organizer
      10th International Conference on Molecular Electronics & BioElectronics
    • Related Report
      2019 Annual Research Report
  • [Presentation] A Thin Composite Emission Filter and Fiber Coupled Laser Excitation for Implantable Fluorescence Imager Application2019

    • Author(s)
      Erus Rustami, Kiyotaka Sasagawa, Yasumi Ohta, Makito Haruta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      The IEEE International Symposium on Circuits and Systems (ISCAS)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Implantable CMOS image sensors for biomedical imaging2019

    • Author(s)
      K. Sasagawa, M. Haruta, T. Tokuda, J. Ohta
    • Organizer
      2019 Symposium for the Promotion of Applied Research Collaboration in Asia(SPARCA2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Lensless fluorescence microscope2019

    • Author(s)
      K. Sasagawa, A. Kimura, Y. Ohta, M. Haruta, T. Noda, T. Tokuda, J. Ohta
    • Organizer
      4th International Workshop on Image Sensors and Imaging Systems
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 入射角度分解画素CMOSイメージセンサの試作2019

    • Author(s)
      杉江 謙治, 笹川 清隆, ギント マーク, 春田 牧人, 徳田 崇, 太田 淳
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Application of High Performance Hybrid Filter on CMOS Image Sensor for FRET Imaging2019

    • Author(s)
      Wan Shen Hee, Aiki Kameyama, Ayaka Kimura, Kiyotaka Sasagawa, Makito Haruta, Takashi Tokuda, Jun Ohta
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ハイブリッドフィルタを用いた広視野レンズレス蛍光イメージングデバイス2019

    • Author(s)
      笹川 清隆, 太田 安美, 河原 麻実子, 春田 牧人, 徳田 崇, 太田 淳
    • Organizer
      第66回応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A needle shape fluorescence micro-imager with interference and absorption filters2019

    • Author(s)
      Erus Rustami, Kiyotaka Sasagawa, Yasumi Ohta, Makito Haruta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      平成31年電気学会全国大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Composite bandpass emission filter for lensless fluorescence imaging2018

    • Author(s)
      K. Sasagawa, Y. Ohta, M. Haruta, T. Noda, T. Tokuda, J. Ohta
    • Organizer
      IEEE LSC 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Excitation and emission filters for implantable fluorescence imaging devices by laser lift-off process2018

    • Author(s)
      K. Sasagawa, Y. Ohta, M. Haruta, T. Noda, T. Tokuda, J. Ohta
    • Organizer
      IEEE BioCAS 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Small and compact in-vivo FRET image Sensor - fabrication and development using CMOS technology2018

    • Author(s)
      W.-S. Hee, M. Haruta, T. Noda, K. Sasagawa, T. Tokuda, J. Ohta
    • Organizer
      2018 International Conference on Solid State Devices and Materials
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A lens-free imaging device with a hybrid emission filter for fluorescent microchamber counting2018

    • Author(s)
      K. Sasagawa, N. Ikeda, M. Haruta, H. Takehara, T. Noda, T. Tokuda and J. Ohta
    • Organizer
      the 40th International Engineering in Medicine and Biology Conference
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] FRET計測に向けたハイブリッド型励起光除去フィルタ搭載CMOSイメージングデバイス2018

    • Author(s)
      亀山 愛樹, HEE WAN SHEN, 木村 文香, 春田 牧人, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
    • Organizer
      バイオ・マイクロシステム研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] FERT計測用レンズレス蛍光 CMOSイメージングデバイスの光学特性評価2018

    • Author(s)
      亀山 愛樹, Hee Wan-Shen, 木村 文香, 春田 牧人, 野田 俊彦, 笹川 清隆, 徳田 崇, 太田 淳
    • Organizer
      映像情報メディア学会年次学会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] バンドパスハイブリッドフィルタによる高感度レンズレス蛍光イメージング2018

    • Author(s)
      笹川 清隆, 太田 安美, 野田 俊彦, 徳田 崇, 太田 淳
    • Organizer
      第79回応用物理学会 秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] An Implantable CMOS Image Sensor Using Fiber Coupled Laser Excitation2018

    • Author(s)
      Erus Rustami, Yasumi Ohta, Kiyotaka Sasagawa, Makito Haruta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      第79回応用物理学会 秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] レンズレス蛍光イメージングによる細胞のタイムラプス観察2018

    • Author(s)
      笹川 清隆, 木村 文香, 春田 牧人, 野田 俊彦, 徳田 崇, 太田 淳
    • Organizer
      映像情報メディア学会情報センシング研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Implantable CMOS Image Sensor using Multilayer Filter Emission and Fiber Coupled Laser Excitation2018

    • Author(s)
      Erus Rustami, Kiyotaka Sasagawa, Yasumi Ohta, Makito Haruta, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      4th International Workshop on Image Sensors and Imaging Systems (IWISS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] Functional Brain Mapping: Methods and Aims2020

    • Author(s)
      Kiyotaka Sasagawa, Makito Haruta, Yasumi Ohta, Hironari Takehara, Takashi Tokuda, Jun Ohta
    • Total Pages
      26
    • Publisher
      Springer
    • ISBN
      9789811568831
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光観察用フィルタ及び蛍光観察顕微鏡2018

    • Inventor(s)
      笹川 清隆, 春田 牧人, 野田 俊彦, 徳田 崇, 太田 淳
    • Industrial Property Rights Holder
      笹川 清隆, 春田 牧人, 野田 俊彦, 徳田 崇, 太田 淳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-160638
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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