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Evaluation of Chemical Susceptibility Diversity by mlAOP Concept and its Application to Understanding Insecticide Poisoning

Research Project

Project/Area Number 18H04132
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 63:Environmental analyses and evaluation and related fields
Research InstitutionHokkaido University

Principal Investigator

IKENAKA Yoshinori  北海道大学, 獣医学研究院, 教授 (40543509)

Co-Investigator(Kenkyū-buntansha) 星 信彦  神戸大学, 農学研究科, 教授 (10209223)
川合 佑典  帯広畜産大学, 畜産学部, 助教 (10709546)
石塚 真由美  北海道大学, 獣医学研究院, 教授 (50332474)
小林 篤史  北海道大学, 獣医学研究院, 准教授 (50431507)
久保田 彰  帯広畜産大学, 畜産学部, 准教授 (60432811)
水川 葉月  愛媛大学, 農学研究科, 准教授 (60612661)
有薗 幸司  熊本大学, 大学院生命科学研究部(薬), 特任教授 (70128148)
平野 哲史  富山大学, 学術研究部薬学・和漢系, 助教 (70804590)
加藤 恵介  東邦大学, 薬学部, 教授 (80276609)
宮原 裕一  信州大学, 学術研究院理学系, 教授 (80311330)
市川 剛  獨協医科大学, 医学部, 非常勤講師 (80438712)
岡松 優子  北海道大学, 獣医学研究院, 准教授 (90527178)
中山 翔太  北海道大学, 獣医学研究院, 准教授 (90647629)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2021: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2020: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2019: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywordsネオニコチノイド / mlAOPコンセプト / 発達神経毒性試験 / 化学物質感受性決定機構 / バイオマーカー / 発達神経毒性試験n / 化学物質感受性決定帰国
Outline of Final Research Achievements

In this study, we tested a new assessment concept, mlAOP, to evaluate species diversity in toxic effects. As a model compound, we focused on neonicotinoids (NN) and compared their neurotoxic effects on mice, zebrafish, and Xenopus. As a result, behavioral abnormalities and neurotransmitter disturbances were observed in both species at exposure levels below the non-toxic dose (NOAEL). Furthermore, in order to evaluate the sensitivity of a wide range of wild animal species, this study constructed an evaluation system focusing on skin fibroblasts, and evaluated the effects of NN in diverse species.
Clinical studies conducted to evaluate human exposure and health effects were the first in the world to identify the source of exposure to neonicotinoids.

Academic Significance and Societal Importance of the Research Achievements

化学物質の毒性影響評価において、特に神経系の毒性評価が不十分である可能性が指摘されてきた。本研究では、神経系毒性に対し、mlAOPコンセプトを用いた新たなバイオマーカーの探索、および高感度・高精度な分析手法を構築できたこと、また、脳神経活動の撹乱を直接検出できる実験系を確立できたことにある。これにより、これまで病理解剖や行動試験一辺倒であった試験系に対し、より簡便で高感度な神経毒性の検出が可能となり、本研究を通じた大きな学術的な成果と言える。一方、ネオニコチノイドの曝露源およびその対策を介入研究で明らかに出来たことに対する社会的なインパクトは大きい。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (154 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (13 results) Journal Article (49 results) (of which Int'l Joint Research: 33 results,  Peer Reviewed: 49 results,  Open Access: 27 results) Presentation (84 results) (of which Int'l Joint Research: 42 results,  Invited: 2 results) Remarks (5 results) Funded Workshop (3 results)

  • [Int'l Joint Research] North-West University(南アフリカ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Buea(カメルーン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] KNUST(ガーナ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] North-West University(南アフリカ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Zambia(ザンビア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] KNUST(ガーナ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Kasetsart University(タイ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] North-West University/Johannesburg University(南アフリカ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] カセサート大学(タイ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] モンゴル国立大学/モンゴル獣医生命大学(モンゴル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] KNUST(ガーナ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] North-West University(南アフリカ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Avairo University(ポルトガル)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy <i>in vivo</i> imaging2022

    • Author(s)
      NISHI Misaki、SUGIO Shouta、HIRANO Tetsushi、KATO Daisuke、WAKE Hiroaki、SHODA Asuka、MURATA Midori、IKENAKA Yoshinori、TABUCHI Yoshiaki、MANTANI Youhei、YOKOYAMA Toshifumi、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 84 Issue: 4 Pages: 585-592

    • DOI

      10.1292/jvms.22-0013

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand2022

    • Author(s)
      Furuta Yoshikazu、Miura Fumihito、Ichise Takahiro、Nakayama Shouta M. M.、Ikenaka Yoshinori、Zorigt Tuvshinzaya、Tsujinouchi Mai、Ishizuka Mayumi、Ito Takashi、Higashi Hideaki
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 3 Pages: e0265225-e0265225

    • DOI

      10.1371/journal.pone.0265225

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety Assessment of Ultrasound-Assisted Intravesical Chemotherapy in Normal Dogs: A Pilot Study2022

    • Author(s)
      Sasaki Noboru、Ikenaka Yoshinori、Aoshima Keisuke、Aoyagi Teiichiro、Kudo Nobuki、Nakamura Kensuke、Takiguchi Mitsuyoshi
    • Journal Title

      Frontiers in Pharmacology

      Volume: 13 Pages: 837754-837754

    • DOI

      10.3389/fphar.2022.837754

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ca2+ imaging with two-photon microscopy to detect the disruption of brain function in mice administered neonicotinoid insecticides2022

    • Author(s)
      Hirai Anri、Sugio Shouta、Nimako Collins、Nakayama Shouta M. M.、Kato Keisuke、Takahashi Keisuke、Arizono Koji、Hirano Tetsushi、Hoshi Nobuhiko、Fujioka Kazutoshi、Taira Kumiko、Ishizuka Mayumi、Wake Hiroaki、Ikenaka Yoshinori
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 5114-5114

    • DOI

      10.1038/s41598-022-09038-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population2022

    • Author(s)
      Nimako Collins、Ichise Takahiro、Hasegawa Hiroshi、Akoto Osei、Boadi Nathaniel O.、Taira Kumiko、Fujioka Kazutoshi、Isoda Norikazu、Nakayama Shouta M.M.、Ishizuka Mayumi、Ikenaka Yoshinori
    • Journal Title

      Environment International

      Volume: 162 Pages: 107169-107169

    • DOI

      10.1016/j.envint.2022.107169

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolomic Alteration in the Plasma of Wild Rodents Environmentally Exposed to Lead: A Preliminary Study2022

    • Author(s)
      Nakata Hokuto、Eguchi Akifumi、Nakayama Shouta M. M.、Yabe John、Muzandu Kaampwe、Ikenaka Yoshinori、Mori Chisato、Ishizuka Mayumi
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 1 Pages: 541-541

    • DOI

      10.3390/ijerph19010541

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutathione S-transferase gene polymorphisms in association with susceptibility to lead toxicity in lead- and cadmium-exposed children near an abandoned lead-zinc mining area in Kabwe, Zambia2021

    • Author(s)
      Yohannes Yared Beyene、Nakayama Shouta M. M.、Yabe John、Toyomaki Haruya、Kataba Andrew、Nakata Hokuto、Muzandu Kaampwe、Ikenaka Yoshinori、Choongo Kennedy、Ishizuka Mayumi
    • Journal Title

      Environmental Science and Pollution Research

      Volume: 29 Issue: 5 Pages: 6622-6632

    • DOI

      10.1007/s11356-021-16098-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka2021

    • Author(s)
      Taira Kumiko、Kawakami Tomonori、Weragoda Sujithra Kaushaliya、Herath H. M. Ayala S.、Ikenaka Yoshinori、Fujioka Kazutoshi、Hemachandra Madhubhani、Pallewatta Nirmalie、Aoyama Yoshiko、Ishizuka Mayumi、Bonmatin Jean-Marc、Komori Makiko
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 22484-22484

    • DOI

      10.1038/s41598-021-01732-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neonicotinoid residues in commercial Japanese tea leaves produced by organic and conventional farming methods2021

    • Author(s)
      Nimako Collins、Hirai Anri、Ichise Takahiro、Akoto Osei、Nakayama Shouta M.M.、Taira Kumiko、Fujioka Kazutoshi、Ishizuka Mayumi、Ikenaka Yoshinori
    • Journal Title

      Toxicology Reports

      Volume: 8 Pages: 1657-1664

    • DOI

      10.1016/j.toxrep.2021.09.002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simultaneous quantification of imidacloprid and its metabolites in tissues of mice upon chronic low-dose administration of imidacloprid2021

    • Author(s)
      Nimako Collins、Ikenaka Yoshinori、Akoto Osei、Fujioka Kazutoshi、Taira Kumiko、Arizono Koji、Kato Keisuke、Takahashi Keisuke、Nakayama Shouta M.M.、Ichise Takahiro、Ishizuka Mayumi
    • Journal Title

      Journal of Chromatography A

      Volume: 1652 Pages: 462350-462350

    • DOI

      10.1016/j.chroma.2021.462350

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Simultaneous steroids measurement in dogs with hyperadrenocorticism using a column-switching liquid chromatography-tandem mass spectrometry method2021

    • Author(s)
      SASAKI Noboru、OO Thandar、YASUDA Yoshikazu、ICHISE Takahiro、NAGATA Noriyuki、YOKOYAMA Nozomu、SASAOKA Kazuyoshi、MORISHITA Keitaro、NAKAYAMA Shouta MM、ISHIZUKA Mayumi、NAKAMURA Kensuke、TAKIGUCHI Mitsuyoshi、IKENAKA Yoshinori
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 11 Pages: 1634-1642

    • DOI

      10.1292/jvms.21-0406

    • NAID

      130008109060

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resolving the twin human and environmental health hazards of a plant-based diet2020

    • Author(s)
      Wyckhuys Kris A.G.、Aebi Alexandre、Bijleveld van Lexmond Maarten F.I.J.、Bojaca Carlos R.、Bonmatin Jean-Marc、Furlan Lorenzo、Guerrero Jairo A.、Mai Trinh V.、Pham Hoi V.、Sanchez-Bayo Francisco、Ikenaka Yoshinori
    • Journal Title

      Environment International

      Volume: 144 Pages: 106081-106081

    • DOI

      10.1016/j.envint.2020.106081

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Acute exposure to environmentally relevant lead levels induces oxidative stress and neurobehavioral alterations in larval zebrafish (Danio rerio)2020

    • Author(s)
      Kataba Andrew、Botha Tarryn L.、Nakayama Shouta M.M.、Yohannes Yared B.、Ikenaka Yoshinori、Wepener Victor、Ishizuka Mayumi
    • Journal Title

      Aquatic Toxicology

      Volume: 227 Pages: 105607-105607

    • DOI

      10.1016/j.aquatox.2020.105607

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Trophic transfer of pollutants within two intertidal rocky shore ecosystems in different biogeographic regions of South Africa2020

    • Author(s)
      Erasmus Anja、Ikenaka Yoshinori、Nakayama Shouta M.M.、Ishizuka Mayumi、Smit Nico J.、Wepener Victor
    • Journal Title

      Marine Pollution Bulletin

      Volume: 157 Pages: 111309-111309

    • DOI

      10.1016/j.marpolbul.2020.111309

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Altered hepatic cytochrome P450 expression in cats after chronic exposure to decabromodiphenyl ether (BDE-209)2020

    • Author(s)
      KHIDKHAN Kraisiri、MIZUKAWA Hazuki、IKENAKA Yoshinori、NAKAYAMA Shouta M. M.、NOMIYAMA Kei、YOKOYAMA Nozomu、ICHII Osamu、TAKIGUCHI Mitsuyoshi、TANABE Shinsuke、ISHIZUKA Mayumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 7 Pages: 978-982

    • DOI

      10.1292/jvms.20-0140

    • NAID

      130007882366

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice2020

    • Author(s)
      TAKADA Tadashi、YONEDA Naoki、HIRANO Tetsushi、ONARU Kanoko、MANTANI Youhei、YOKOYAMA Toshifumi、KITAGAWA Hiroshi、TABUCHI Yoshiaki、NIMAKO Collins、ISHIZUKA Mayumi、IKENAKA Yoshinori、HOSHI Nobuhiko
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Issue: 3 Pages: 350-359

    • DOI

      10.1292/jvms.19-0635

    • NAID

      130007814907

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice2020

    • Author(s)
      Ohno Shuji、Ikenaka Yoshinori、Onaru Kanoko、Kubo Shizuka、Sakata Nanami、Hirano Tetsushi、Mantani Youhei、Yokoyama Toshifumi、Takahashi Keisuke、Kato Keisuke、Arizono Koji、Ichise Takahiro、Nakayama Shouta M.M.、Ishizuka Mayumi、Hoshi Nobuhiko
    • Journal Title

      Toxicology Letters

      Volume: 322 Pages: 32-38

    • DOI

      10.1016/j.toxlet.2020.01.003

    • NAID

      120006811093

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dichlorodiphenyltrichloroethane (DDT) levels in rat livers collected from a malaria vector control region2019

    • Author(s)
      MOTOHIRA Kodai、IKENAKA Yoshinori、YOHANNES Yared Beyene、NAKAYAMA Shouta M. M.、WEPENER Victor、SMIT Nico J.、VAN VUREN Johan H. J.、SOUSA Ana Catarina、ENUNEKU Alex Ajeh、OGBOMIDA Emmanuel Temiotan、ISHIZUKA Mayumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 11 Pages: 1575-1579

    • DOI

      10.1292/jvms.19-0168

    • NAID

      130007744347

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells2019

    • Author(s)
      Hirano Tetsushi、Minagawa Satsuki、Furusawa Yukihiro、Yunoki Tatsuya、Ikenaka Yoshinori、Yokoyama Toshifumi、Hoshi Nobuhiko、Tabuchi Yoshiaki
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 383 Pages: 114777-114777

    • DOI

      10.1016/j.taap.2019.114777

    • NAID

      120006941664

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] How toxic is a non-toxic nanomaterial: Behaviour as an indicator of effect in Danio rerio exposed to nanogold2019

    • Author(s)
      Botha Tarryn L.、Brand Sarel J.、Ikenaka Yoshinori、Nakayama Shouta M.M.、Ishizuka Mayumi、Wepener Victor
    • Journal Title

      Aquatic Toxicology

      Volume: 215 Pages: 105287-105287

    • DOI

      10.1016/j.aquatox.2019.105287

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
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    • Author(s)
      Khidkhan K, Mizukawa H, Ikenaka Y, Nakayama SMM, Nomiyama K, Yokoyama N, Ichii O, Darwish WS, Takiguchi M, Tanabe S, Ishizuka M
    • Journal Title

      Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

      Volume: 226 Pages: 108613-108613

    • DOI

      10.1016/j.cbpc.2019.108613

    • NAID

      120006937043

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
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    • Author(s)
      Thompson Lesa A.、Ikenaka Yoshinori、Sobhy Darwish Wageh、Nakayama Shouta M.M.、Mizukawa Hazuki、Ishizuka Mayumi
    • Journal Title

      Environmental Toxicology and Pharmacology

      Volume: 72 Pages: 103249-103249

    • DOI

      10.1016/j.etap.2019.103249

    • NAID

      120006941695

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
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    • Author(s)
      Volschenk C.M.、Gerber R.、Mkhonto M.T.、Ikenaka Y.、Yohannes Y.B.、Nakayama S.、Ishizuka M.、van Vuren J.H.J.、Wepener V.、Smit N.J.
    • Journal Title

      Science of The Total Environment

      Volume: 685 Pages: 1116-1126

    • DOI

      10.1016/j.scitotenv.2019.06.144

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syntheses of 4‐OH and 5‐OH Imidacloprids2019

    • Author(s)
      Takahashi Keisuke、Tsurumi Tatsuya、Inami Moe、Li Zui、Kusakabe Taichi、Kikkawa Shoko、Azumaya Isao、Tominaga Nobuaki、Ikenaka Yoshinori、Arizono Koji、Kato Keisuke
    • Journal Title

      ChemistrySelect

      Volume: 4 Issue: 24 Pages: 7343-7345

    • DOI

      10.1002/slct.201901491

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth2019

    • Author(s)
      Ichikawa Go、Kuribayashi Ryota、Ikenaka Yoshinori、Ichise Takahiro、Nakayama Shouta M. M.、Ishizuka Mayumi、Taira Kumiko、Fujioka Kazutoshi、Sairenchi Toshimi、Kobashi Gen、Bonmatin Jean-Marc、Yoshihara Shigemi
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 7 Pages: 0219208-0219208

    • DOI

      10.1371/journal.pone.0219208

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of PCB exposure on serum thyroid hormone levels in dogs and cats2019

    • Author(s)
      Takaguchi Kohki、Nishikawa Hiroyuki、Mizukawa Hazuki、Tanoue Rumi、Yokoyama Nozomu、Ichii Osamu、Takiguchi Mitsuyoshi、Nakayama Shouta M.M.、Ikenaka Yoshinori、Kunisue Tatsuya、Ishizuka Mayumi、Tanabe Shinsuke、Iwata Hisato、Nomiyama Kei
    • Journal Title

      Science of The Total Environment

      Volume: 688 Pages: 1172-1183

    • DOI

      10.1016/j.scitotenv.2019.06.300

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One year exposure to Cd- and Pb-contaminated soil causes metal accumulation and alteration of global DNA methylation in rats2019

    • Author(s)
      Nakayama Shouta M.M.、Nakata Hokuto、Ikenaka Yoshinori、Yabe John、Oroszlany Balazs、Yohannes Yared B.、Bortey-Sam Nesta、Muzandu Kaampwe、Choongo Kennedy、Kuritani Takeshi、Nakagawa Mitsuhiro、Ishizuka Mayumi
    • Journal Title

      Environmental Pollution

      Volume: 252 Pages: 1267-1276

    • DOI

      10.1016/j.envpol.2019.05.038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evidence of impacts from DDT in pelican, cormorant, stork, and egret eggs from KwaZulu-Natal, South Africa.2019

    • Author(s)
      H. Bouwman, Y.B. Yohannes, S.M.M. Nakayama, K. Motohira, M. Ishizuka, M.S. Humphries, V. van der Schyff, M. du Preez, A. Dinkelmann, Y. Ikenaka.
    • Journal Title

      Chemosphere (in press)

      Volume: - Pages: 647-658

    • DOI

      10.1016/j.chemosphere.2019.03.043

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques2019

    • Author(s)
      Uno Yasuhiro、Takahira Rika、Murayama Norie、Onozeki Shunsuke、Kawamura Shu、Uehara Shotaro、Ikenaka Yoshinori、Ishizuka Mayumi、Ikushiro Shinichi、Yamazaki Hiroshi
    • Journal Title

      Biochemical Pharmacology

      Volume: 163 Pages: 335-344

    • DOI

      10.1016/j.bcp.2019.03.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] aseline bio-accumulation concentrations and resulting oxidative stress in Synodontis zambezensis after an acute laboratory exposure to 4,4’-DDT. Pesticide Biochemistry and Physiology.2019

    • Author(s)
      C.M. Volschek, Y. Ikenaka, Y.B. Yohannes, S.M. Nakayama, M. Ishizuka, E. Smit, J.H.J. van Vuren, R. Greenfield.
    • Journal Title

      Pesticide Biochemistry and Physiology (in press)

      Volume: - Pages: 44-55

    • DOI

      10.1016/j.pestbp.2019.02.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A review: poisoning by anticoagulant rodenticides in non-target animals globally2019

    • Author(s)
      Nakayama SMM, Morita A, Ikenaka Y, Mizukawa H, Ishizuka M.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 2 Pages: 298-313

    • DOI

      10.1292/jvms.17-0717

    • NAID

      130007605094

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of function and genetic feature of UDP-glucuronosyltransferase in avian species2019

    • Author(s)
      Kawai Yusuke K.、Shinya So、Ikenaka Yoshinori、Saengtienchai Aksorn、Kondo Takamitsu、Darwish Wageh Sobhy、Nakayama Shota M.M.、Mizukawa Hazuki、Ishizuka Mayumi
    • Journal Title

      Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

      Volume: 217 Pages: 5-14

    • DOI

      10.1016/j.cbpc.2018.11.001

    • NAID

      120006803956

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The evolution of UDP-glycosyl/glucuronosyltransferase 1E (UGT1E) genes in bird lineages is linked to feeding habits but UGT2 genes is not.2018

    • Author(s)
      Yusuke K. Kawai, Yoshinori Ikenaka, Mayumi Ishizuka, Akira Kubota
    • Journal Title

      PLoS One

      Volume: 13 Issue: 10 Pages: 1-13

    • DOI

      10.1371/journal.pone.0205266

    • NAID

      120006540774

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] First report on OH-PAHs in South African Clarias gariepinus bile from an urban impacted system2018

    • Author(s)
      Pheiffer W、Bortey-Sam N、Ikenaka Y、Nakayama SMM、Mizukawa H、Ishizuka M、Smit NJ、Pieters R
    • Journal Title

      African Journal of Aquatic Science

      Volume: 43 Issue: 3 Pages: 305-312

    • DOI

      10.2989/16085914.2018.1511408

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats ( Rattus rattus ) in Tokyo by in situ liver perfusion2018

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Kazuyuki D.Tanaka, Shouta M.M .Nakayama, Tsutomu Tanikawa, Hazuki Mizukawa, Mayumi Ishizuka
    • Journal Title

      Pesticide Biochemistry and Physiology

      Volume: in press Pages: 42-49

    • DOI

      10.1016/j.pestbp.2018.03.018

    • NAID

      120006636185

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and functional characterization of UDP-glucuronosyltransferase 1A in cynomolgus macaques.2018

    • Author(s)
      Uno, Y., Takahira, R., Murayama, N., Ishii, Y., Ikenaka, Y., Ishizuka, M., Yamazaki, H., and Ikushiro, S.
    • Journal Title

      Biochem. Pharmacol.

      Volume: 155 Pages: 172-181

    • DOI

      10.1016/j.bcp.2018.06.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Linking organochlorine exposure to biomarker response patterns in Anurans: a case study of M?ller’s clawed frog (Xenopus muelleri) from a tropical malaria vector control region2018

    • Author(s)
      Wolmarans Nico J、Du Preez Louis H、Yohannes Yared Beyene、Ikenaka Yoshinori、Ishizuka Mayumi、Smit Nico J、Wepener Victor
    • Journal Title

      Ecotoxicology

      Volume: 27 Issue: 9 Pages: 1203-1216

    • DOI

      10.1007/s10646-018-1972-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species2018

    • Author(s)
      Saengtienchai A, Ikenaka Y, Kawata M, Kawai Y, Takeda K, Kondo T, Bortey-Sam N, Nakayama S.M.M, Mizukawa H, Ishizuka M.
    • Journal Title

      CBP

      Volume: 214 Pages: 28-35

    • DOI

      10.1016/j.cbpc.2018.08.007

    • NAID

      120006769940

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization and imaging of lead distribution in bones of lead-exposed birds by ICP-MS and LA-ICP-MS2018

    • Author(s)
      Ishii Chihiro、Nakayama Shouta M.M.、Kataba Andrew、Ikenaka Yoshinori、Saito Keisuke、Watanabe Yukiko、Makino Yoshiki、Matsukawa Takehisa、Kubota Ayano、Yokoyama Kazuhito、Mizukawa Hazuki、Hirata Takafumi、Ishizuka Mayumi
    • Journal Title

      Chemosphere

      Volume: 212 Pages: 994-1001

    • DOI

      10.1016/j.chemosphere.2018.08.149

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle2018

    • Author(s)
      BORTEY-SAM Nesta、IKENAKA Yoshinori、AKOTO Osei、NAKAYAMA Shouta M.M.、MARFO Jemima T.、SAENGTIENCHAI Aksorn、MIZUKAWA Hazuki、ISHIZUKA Mayumi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 375-381

    • DOI

      10.1292/jvms.17-0410

    • NAID

      130006410766

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accumulation patterns and risk assessment of metals and metalloid in muscle and offal of free-range chickens, cattle and goat in Benin City, Nigeria2018

    • Author(s)
      Ogbomida Emmanuel Temiotan、Nakayama Shouta M.M.、Bortey-Sam Nesta、Oroszlany Balazs、Tongo Isioma、Enuneku Alex Ajeh、Ozekeke Ogbeide、Ainerua Martins Oshioriamhe、Fasipe Iriagbonse Priscillia、Ezemonye Lawrence Ikechukwu、Mizukawa Hazuki、Ikenaka Yoshinori、Ishizuka Mayumi
    • Journal Title

      Ecotoxicol Environ Saf

      Volume: 151 Pages: 98-108

    • DOI

      10.1016/j.ecoenv.2017.12.069

    • NAID

      120006842182

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana2018

    • Author(s)
      Bortey-Sam Nesta、Ikenaka Yoshinori、Akoto Osei、Nakayama Shouta M.M.、Asante Kwadwo A.、Baidoo Elvis、Obirikorang Christian、Mizukawa Hazuki、Ishizuka Mayumi
    • Journal Title

      Environ Pollut.

      Volume: 235 Pages: 163-170

    • DOI

      10.1016/j.envpol.2017.12.005

    • NAID

      120006820161

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] “Caddisfly watch,” a biomonitoring program using Stenopsyche larvae to determine radioactive cesium contamination in rivers following the Fukushima nuclear disaster2018

    • Author(s)
      Ueno, D., Mizukawa, H., Inanami, O., Nagasaka, H., Tatsuta, N., Narazaki, Y., Fujino, T., Watanabe, I., Kameda, Y. and Nakai, K
    • Journal Title

      Landscape Ecol. Eng.

      Volume: 14 Issue: 1 Pages: 29-35

    • DOI

      10.1007/s11355-017-0333-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A glycomics approach to discover novel renal biomarkers in birds by administration of cisplatin and diclofenac to chickens2018

    • Author(s)
      Ishii C、Ikenaka Y、Ichii O、Nakayama S M M、Nishimura S-I、Ohashi T、Tanaka M、Mizukawa H、Ishizuka M
    • Journal Title

      Poultry Science

      Volume: 97 Issue: 5 Pages: 1722-1729

    • DOI

      10.3382/ps/pey016

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human Health Risk from Consumption of Marine Fish Contaminated with DDT and Its Metabolites in Maputo Bay, Mozambique2018

    • Author(s)
      Thompson L. A.、Ikenaka Y.、Yohannes Y. B.、Ichise T.、Ito G.、Bortey-Sam N.、van Vuren J. J.、Wepener V.、Smit N. J.、Darwish W. S.、Nakayama S. M. M.、Mizukawa H.、Ishizuka M.
    • Journal Title

      Bulletin of Environmental Contamination and Toxicology

      Volume: 100 Issue: 5 Pages: 672-676

    • DOI

      10.1007/s00128-018-2323-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR2018

    • Author(s)
      Kumiko Yamamoto, Yoshinori Ikenaka, Takahiro Ichise, Tomoki Bo, Mayumi Ishizuka, Hironobu Yasui, Wakako Hiraoka, Tohru Yamamori, Osamu Inanami
    • Journal Title

      Free Radical Research

      Volume: - Issue: 6 Pages: 648-660

    • DOI

      10.1080/10715762.2018.1460472

    • NAID

      120006606587

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occurrence and seasonal variation of equine estrogens, equilin and equilenin, in the river water of Japan: Implication with endocrine-disrupting potentials to Japanese medaka (Oryzias latipes)2018

    • Author(s)
      Ishibashi Hiroshi、Uchida Masaya、Yoshimoto Keisuke、Imamura Yuta、Yamamoto Ryoko、Ikenaka Yoshinori、Kawai Masahito、Ichikawa Nobuhiro、Takao Yuji、Tominaga Nobuaki、Ishibashi Yasuhiro、Arizono Koji
    • Journal Title

      Environmental Pollution

      Volume: 239 Pages: 281-288

    • DOI

      10.1016/j.envpol.2018.04.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contamination by neonicotinoid insecticides and their metabolites in Sri Lankan black tea leaves and Japanese green tea leaves2018

    • Author(s)
      Ikenaka Yoshinori、Fujioka Kazutoshi、Kawakami Tomonori、Ichise Takahiro、Bortey-Sam Nesta、Nakayama Shouta M.M.、Mizukawa Hazuki、Taira Kumiko、Takahashi Keisuke、Kato Keisuke、Arizono Koji、Ishizuka Mayumi
    • Journal Title

      Toxicology Reports

      Volume: 5 Pages: 744-749

    • DOI

      10.1016/j.toxrep.2018.06.008

    • NAID

      120006551597

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EXPOSURES OF CHILDREN TO NEONICOTINOIDS IN PINE WILT DISEASE CONTROL AREAS2018

    • Author(s)
      Ikenaka Yoshinori、Miyabara Yuichi、Ichise Takahiro、Nakayama Shouta M.M.、Nimako Collins、Ishizuka Mayumi、Tohyama Chiharu
    • Journal Title

      Environmental Toxicology and Chemistry

      Volume: 38 Issue: 1 Pages: 71-79

    • DOI

      10.1002/etc.4316

    • NAID

      120006776813

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] ニコチン性アセチルコリン受容体アゴニストによるシグナル毒性と2光子顕微鏡を用いた検出手法の開発2020

    • Author(s)
      平井杏梨、杉尾翔太、池中良徳、Collins Nimako、中山翔太、星信彦、和氣弘明、石塚真由美
    • Organizer
      第47回日本毒性学会学術年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 行動毒性試験および二光子イメージングによるアセタミプリドの神経毒性評価2020

    • Author(s)
      平井杏梨、杉尾翔太、池中良徳、Collins Nimako、中山翔太、星信彦、和氣弘明、石塚真由美
    • Organizer
      163回日本獣医学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Species variations in cytochrome P450-mediated metabolism of neonicotinoids among cats, dogs, rats, and humans2020

    • Author(s)
      Kraisiri Khidkhan, Yoshinori Ikenaka, Takahiro Ichise, Shouta M. M. Nakayama, Hazuki Mizukawa, Kei Nomiyama, Hisato Iwata, Koji Arizono, Keisuke Takahashi, Keisuke Kato ,and Mayumi Ishizuka
    • Organizer
      環境化学オンライン研究発表会2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] An adverse outcome pathway-based assessment of steatogenic effects of imidacloprid in livers of C57BL/6J Male Mice2020

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Jussiaea V. BARIUAN, Atsushi KOBAYASHI, Ryo YAMAZAKI, Shouta M.M. NAKAYAMA, and Mayumi ISHIZUKA
    • Organizer
      環境化学オンライン研究発表会2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 行動毒性試験と二光子顕微鏡の併用によるアセタミプリドのシグナル毒性検出2020

    • Author(s)
      平井杏梨、杉尾翔太、池中良徳、Collins Nimako、中山翔太、星信彦、和氣弘明、石塚真由美
    • Organizer
      環境化学オンライン研究発表会2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An adverse outcome pathway-based assessment of steatogenic effects of imidacloprid in livers of C57BL/6J Male Mice2020

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Jussiaea V. BARIUAN, Atsushi KOBAYASHI, Ryo YAMAZAKI, Shouta M.M. NAKAYAMA, and Mayumi ISHIZUKA.
    • Organizer
      The 8th Sapporo Summer Symposium for One Health (8th SaSSOH)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COLLABORATIVE WORK WITH MONGOLIA : EASY, CHEAP AND EFFICIENT METHOD DEVELOPMENT FOR DRUG RESIDUE IN ANIMAL PRODUCTS2020

    • Author(s)
      Kodai Motohira, Yoshinori Ikenaka, Delgermurun Dugar, Takahiro Ichise, Shouta Nakayama, Mayumi Ishizuka.
    • Organizer
      The 8th Sapporo Summer Symposium for One Health (8th SaSSOH)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新興農薬の毒性と安全性2020

    • Author(s)
      池中良徳
    • Organizer
      日本学術会議・日本環境ホルモン学会 合同公開シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Species differences in xenobiotic metabolism by phase I and II enzymes of companion animals and wildlife.2019

    • Author(s)
      Mayumi Ishizuka, Yoshinori Ikenaka, Shouta MM Nakayama.v
    • Organizer
      The 2nd Joint Meeting of Veterinary Science in East Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The trend of elevated blood lead levels in Kabwe mining area, Republic of Zambia.2019

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Kaampwe Muzandu, Yared B. Yohannes, Haruya Toyomaki, Andrew Kataba, Golden Zyambo, Hazuki Mizukawa, Yoshinori Ikenaka, Russel Dowling, Jack Caravanos, Mayumi Ishizuka.
    • Organizer
      SETAC Europe 29th Annual Meeting.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cost-effective mitigation of lead toxicity in rat using indigenous plant Moringa Oleifera.2019

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, Andrew Kataba, Haruya Toyomaki, Rio Doya, John Yabe, Kaampwe Muzandu, Golden Zyambo, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
    • Organizer
      SETAC Europe 29th Annual Meeting.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血漿中のステロイドホルモンの一斉分析法の開発とウマ性ホルモンの季節変動の解明2019

    • Author(s)
      一瀬貴大、池中良徳、三津橋嵩史、中山翔太、Aksorn Saengtienchai、野見山桂、田上瑠美、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 野生ラットを用いたDDT汚染状況の評価、毒性機序の解明2019

    • Author(s)
      本平航大、池中良徳、ヤレド ベイェネ、中山翔太、ビクター ベペナー、ニコ スミッツ、ヨハン ファン フューレン、江口哲史、アナ カタリナ ソウサ、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] LC/MSを用いたイヌ血清中ステロイドホルモンの分析法の確立と副腎疾患モデルを用いた実測2019

    • Author(s)
      白尾大樹、池中良徳、一瀬貴大、中山翔太、佐々木東、永田矩之、水川葉月、滝口満善、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Rodent tooth as a tool for environmental lead (Pb) assessment2019

    • Author(s)
      Andrew Kataba, Shouta M.M. Nakayama, Hokuto Nakata,Haruya Toyomaki,Yared B. Yohannes,Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neonicotinoid Insecticide and High Fat Diet Interactions Potentiate Sidnals of Type 2 Diabetogenesis in a Rodent Model2019

    • Author(s)
      Collins Nimako, Yoshinori Ikenaka, Yuko Okamatsu-Ogura, Atsushi Kobayashi, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DNA methylation in CpG-rich promoter region and Genetic polymorphism of ALAD gene in environmental Lead-Exposed Children from Kabwe, Zambia2019

    • Author(s)
      Yared B. Yohannes, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Haruya Toyomaki, , Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Seasonal change of lead contamination levels in wild rat blood and soil2019

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, Golden Zyambo, John Yabe, Kaampwe Muzandu, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ザンビア共和国カブエ地域における資源採掘に起因した鉛汚染の実態解明と対策の検討2019

    • Author(s)
      中田北斗、中山翔太、John Yabe、Kaampwe Muzandu、豊巻治也、Yared Beyene、Andrew Kataba、Golden Zyambo、Kennedy Choongo、池中良徳、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Investigation of ameliorative effect of Moringa Oleifera on lead toxicity2019

    • Author(s)
      Hokuto Nakata, Shouta M.M. Nakayama, Andrew Kataba, Haruya Toyomaki, Rio Doya, John Yabe, Kaampwe Muzandu, Golden Zyambo, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 摂食プラスチックから海鳥への化学物質の移行の検証2019

    • Author(s)
      田中厚資、綿貫豊、高田秀重、石塚真由美、山下麗、水川薫子、水川葉月、池中良徳、中山翔太
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] In Vivo Pharmacokinetic/pharmacodynamic analysis of first generation anticoagulant rodenticide warfarin with Egyptian fruit bats ( Rousettus aegyptiacus ) for risk assessment of Bonin fruit bats Pteropus pselaphon2019

    • Author(s)
      Shouta M.M. Nakayama, Kosuke Manago, Kazuki Takeda, Ayuko Morita, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characterization and differentiation of xenobiotic metabolism in mammalian animals through glucuronidation and sulfation profiling2019

    • Author(s)
      Aksorn Saengtienchai, Yoshinori Ikenaka, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ネオニコチノイドの母子間移行の実態と移行メカニズムの解明2019

    • Author(s)
      池中良徳、一瀬貴大、ニマコ・コリンズ、市川剛、野見山桂、長谷川浩、中山翔太、星信彦、平久美子、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] PCBs 曝露によるネコ肝トランスクリプトームへの影響2019

    • Author(s)
      水川葉月、Hoa Thanh Ngyuen、岩田久人、野見山桂 、池中良徳、中山翔太、横山望 、市居修 、滝口満喜、Kraisiri Khidkhan、田辺信介、石塚真由美
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] デカブロモジフェニルエーテル(BDE209)の長期曝露がイエネコへ及ぼす影響2019

    • Author(s)
      田中啓介、野見山桂、水川葉月、髙口倖暉、田上瑠美、横山望、市居修、滝口満喜、笹岡一慶、中山翔太、池中良徳、石塚真由美、国末達也、田辺信介
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鳥類の鉛暴露の実態とその毒性2019

    • Author(s)
      石塚真由美、池中良徳、中山翔太
    • Organizer
      希少な鳥を守るには ―野鳥の鳥インフルエンザと鉛汚染対策に向けて― 公開シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Contamination Status of Organohalogen Compounds in Pet Cats, Cat Food and House Dust from Thailand2019

    • Author(s)
      Makoto Shimasaki, Hazuki Mizukawa, Kohki Takaguchi, Aksorn Saengtienchai, Araya Ngamchirttakul, Disdanai Pencharee, Kraisiri Khidkhan, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Tatsuya Kunisue, Shinsuke Tanabe, Kei Nomiyama
    • Organizer
      第28回環境化学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neonicotinoid Insecticide and High Fat Diet Interactions Potentiate Sidnals of Type 2 Diabetogenesis in a Rodent Model2019

    • Author(s)
      Collins Nimako, Yoshinori Ikenaka, Yuko Okamatsu-Ogura, Atsushi Kobayashi, Ryo Yamazaki, Shouta M.M. Nakayama, Mayumi Ishizuka
    • Organizer
      SETAC-Australasia 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of mechanism of rodenticide resistance with closed colonies of rodenticide resistant rats from Tokyo2019

    • Author(s)
      Kazuki Takeda, Yoshinori Ikenaka, Kazuyuki D. Tanaka, Shouta M.M. Nakayama, Tsutomu Tanikawa and Mayumi Ishizuka
    • Organizer
      15th International Congress of Toxicology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Determination of Lead (Pb) exposure on infants living around Pb mining area in Kabwe, Zambia2019

    • Author(s)
      Haruya Toyomaki, John Yabe, Shouta Nakayama, Yared Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka
    • Organizer
      the 15th International Congress of Toxicology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PCR法によるオオワシ(Haliaeetus pelagicus)の孵化前雌雄判定2019

    • Author(s)
      中山翔太、平野なぎ沙、境秀文、五島渉、伊藤真輝、池中良徳、石塚 真由美
    • Organizer
      第25回日本野生動物医学会大会(山口)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 東京都小笠原諸島における殺鼠剤散布のアオウミガメへのリスク評価2019

    • Author(s)
      山村快哉、武田一貴、中山翔太、川合佑典、森田鮎子、小松謙之、北山知代、近藤理美、池中良徳、石塚真由美
    • Organizer
      第25回日本野生動物医学会大会(山口)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鉛汚染は末梢血中の免疫系細胞を変動させるのか?2019

    • Author(s)
      牛根奈々、中山翔太、石塚真由美、羽山伸一
    • Organizer
      第25回日本野生動物医学会大会(山口)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 体内動態および行動毒性試験から見た動物用医薬品フィプロニルの影響評価2019

    • Author(s)
      鈴木智裕、池中良徳、武田一貴、中山翔太、水川葉月、一瀬貴大、佐々木東、笹岡一慶、滝口満喜、石塚真由美
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] LC-MS/MSを用いたイヌ血清中ステロイドホルモンの分析法の確立と内分泌疾患モデルを用いた実測2019

    • Author(s)
      白尾 大樹、池中 良徳、一瀬 貴大、中山 翔太、佐々木 東、永田 矩之、
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 鉛散弾の経口投与によるバルバリーガモの鉛の血中濃度の経時変化および体内分布の解析2019

    • Author(s)
      佐藤裕、石井千尋、中山翔太、一瀬貴大、齊藤慶輔、渡邊有希子、小笠原浩平、鳥本亮太、小林篤史、木村亨史、池中良徳、石塚真由美
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] LC-MS/MSを用いたイヌ尿中メタネフリンおよびノルメタネフリン測定2019

    • Author(s)
      井上裕美子、佐々木東、池中良徳、一瀬貴大、笹岡一慶、大菅辰幸、中山翔太、森下啓太郎、大田寛、石塚真由美、滝口満喜
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Interactions of Imidacloprid with High Fat Diet Potentiate Signals of Type 2 Diabetogenesis in a Rodent Model2019

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atsushi KOBAYASHI, Shouta M.M. NAKAYAMA and Mayumi ISHIZUKA
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rodent tooth as a biomarker for lead (Pb) exposure2019

    • Author(s)
      Andrew Kataba, Shouta M.M. Nakayama, Hokuto Nakata,Haruya Toyomaki,Yared B. Yohannes,Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] G177C Polymorphism and Promoter CpG Methylation of ALAD Gene in Environmental Lead-Exposed Children2019

    • Author(s)
      Yared B. Yohannes, Shouta Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Hokuto Nakata,Yoshinori Ikenaka, Kennedy Chongo, Mayumi Ishizuka
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Current Trends of Blood Lead Levels, Distribution Patterns and Exposure Variations among Household Members in Kabwe, Zambia2019

    • Author(s)
      John Yabe, Shouta MM Nakayama, Hokuto Nakata, Haruya Toyomaki, Yared B Yohannes, Kaampwe Muzandu, Andrew Kataba, Golden Zyambo, Masato Hiwatari, Daiju Narita, Daichi Yamada, Peter Hangoma, Nosiku Sipilanyambe Munyinda, Tiza Mufune, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparative metabolism of PCBs by cytochrome P450 in cat and dog2019

    • Author(s)
      Kraisiri KHIDKHAN, Hazuki MIZUKAWA, Makoto SHIMASAKI, Kei NOMIYAMA, Yoshinori IKENAKA, Shouta M.M. NAKAYAMA, Hisato IWATA and Mayumi ISHIZUKA
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo analysis of rodenticides with Egyptian fruit bats2019

    • Author(s)
      Kosuke MANAGO, Kazuki TAKEDA, Shouta MM NAKAYAMA, Ayuko MORITA, Yoshinori IKENAKA, Mayumi ISHIZUKA
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Monitoring of Dichloro-diphenyl-trichloroethane Accumulation Levels and Elucidation of its Toxicity in the Field Study2019

    • Author(s)
      Kodai Motohira, Yoshinori Ikenaka, Yared Beyene, Shouta Nakayama, Victor Wepener, Nico Smit, Johan van Vuren, Akifumi Eguchi, Mayumi Ishizuka
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of adverse outcome pathways as arisk assessment tool of chemical stressors in wildlife and humans2019

    • Author(s)
      Victor Wepener, Yoshinori Ikenaka, Suanne Bosch, Avela Mbangatha, Shouta MM Nakayama, Mayumi Ishizuka, Tarryn L Botha
    • Organizer
      The 7th Sapporo Summer Symposium for One Health (7th SaSSOH)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗凝血系殺鼠剤が小笠原諸島在来固有種に与える影響の評価2019

    • Author(s)
      真砂皓大、武田 一貴、中山 翔太、森田 鮎子、池中 良徳、石塚 真由美
    • Organizer
      第25回 日本環境毒性学会研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 単回投与試験によるコウモリの抗凝血系殺鼠剤リスクアセスメントの実施2019

    • Author(s)
      真砂皓大、武田 一貴、中山 翔太、森田 鮎子、池中 良徳、石塚 真由美
    • Organizer
      第25回 日本環境毒性学会研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Time trend of blood Pb concentration and toxicological effects of Pb gunshots through oral administration in waterfowl’s2019

    • Author(s)
      Hiroshi Sato, Chihiro Ishii, Shouta M. M. Nakayama, Takahiro Ichise, Keisuke Saito, Yukiko Watanabe, Kohei Ogasawara,Ryota Torimoto, Atushi Kobayashi, Takashi Kimura, Yoshinori Ikenaka, Mayumi Ishizuka
    • Organizer
      第 3 回環境化学会 北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] 摂食プラスチックから海鳥への添加由来化学物質の移行2019

    • Author(s)
      田中厚資, 綿貫豊,高田秀重,石塚真由美, 山下麗, 水川薫子, 水川葉月, 池中良徳, 中山翔太
    • Organizer
      第 3 回環境化学会 北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] Interactions of Imidacloprid with High Fat Diet Potentiate Signals of Type 2 Diabetogenesis in a Rodent Model2019

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atsushi KOBAYASHI, Shouta M.M. NAKAYAMA and Mayumi ISHIZUKA
    • Organizer
      第 3 回環境化学会 北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] Impact of Lead Exposure, Distribution Patterns and Exposure Variations among Household Members in Kabwe, Zambia2019

    • Author(s)
      Yared B. Yohannes, Shouta Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Hokuto Nakata,Yoshinori Ikenaka, Kennedy Chongo, Mayumi Ishizuka
    • Organizer
      第 3 回環境化学会 北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] 室内化学物質汚染の実態解明とリスク評価~ペットはヒトの歩哨動物として用いられるか?~2019

    • Author(s)
      Hazuki Mizukawa, Kei Nomiyama, Yoshinori Ikenaka, Kraisiri Khidkhan, Shouta MM Nakayama, Mayumi Ishizuka
    • Organizer
      第 3 回環境化学会 北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] タイのペットネコにおける有機ハロゲン化合物の汚染実態2019

    • Author(s)
      Makoto Shimasaki, Hazuki Mizukawa, Kohki Takaguchi, Aksorn Saengtienchai, Araya Ngamchirttakul, Disdanai Pencharee, Kraisiri Khidkhan, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Tatsuya Kunisue, Shinsuke Tanabe, Kei Nomiyama
    • Organizer
      第 3 回環境化学会 北海道東北地区部会 & 3rd Chemical Hazard Symposium in 札幌
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pharmacokinetic/pharmacodynamic analysis of first-generation anticoagulant rodenticide warfarin with Egyptian fruit bats (Rousettus aegyptiacus)2019

    • Author(s)
      Shouta MM NAKAYAMA, Kosuke MANAGO, Kazuki TAKEDA, Ayuko MORITA, Yoshinori IKENAKA, Mayumi ISHIZUKA
    • Organizer
      SETAC North America 40th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) reveals detailed distribution patterns of Pb in mice organs2019

    • Author(s)
      Shouta M.M. Nakayama, Masao Togao, Yoshinori Ikenaka, Yoshiki Makino, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Takafumi Hirata, Mayumi Ishizuka
    • Organizer
      SETAC North America 40th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「基質結合部位からも活性残基からも離れたアミノ酸変異はどのように殺鼠剤抵抗性に寄与するのか?」ドッキングシミュレーション・分子動力学シミュレーションによるビタミンKエポキシド還元酵素の解析2019

    • Author(s)
      武田一貴、池中良徳、フルシュデニス、田中和之、中山翔太、谷川力、トリキドハ、シンハオリー、石塚真由美
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DDTによる異物代謝酵素の遺伝子発現撹乱と健康影響評価2019

    • Author(s)
      本平 航大, 池中 良徳, Yared Beyene, 中山 翔太, 江口 哲史, 武田 一貴, Victor Wepener, Nico Smit, Johan Van Vuren, 石塚 真由美
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Tracing Life History of Immature Antarctic Minke Whales: Stable Isotope Oscillation in Baleen Revealed Ontogenetic Diet Shifts and Seasonal Migration2019

    • Author(s)
      Ippei Suzuki, Mayuka Uchida, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Tsutomu Tamura, Kenji Konishi, Takeharu Bando, Yoko Mitani
    • Organizer
      2019 World Marine Mammal Science Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sensitivity of turtles to anticoagulant rodenticides: in vivo and in vitro sensitivity evaluation in green sea turtles (Chelonia mydas mydas) in the Ogasawara Islands2019

    • Author(s)
      Shouta MM Nakayama, Yoshiya Yamamura, Kazuki Takeda, Yusuke Kawai, Ayuko Morita, Yoshinori Ikenaka, Noriyuki Komatsu, Chiho Kezuka, Mari Taniguchi, Chiyo Kitayama, Satomi Kondo, Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of simultaneous analysis method of steroid hormones in blood and measurement of canine adrenal disease2019

    • Author(s)
      Takahiro Ichise,Yoshinori Ikenaka,Diki Shirao, Syouta Nakayama, Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maternal to fetal transfer of systemic pesticide Clothianidin and its metabolites2019

    • Author(s)
      Mai Tamba, Yoshinori Ikenaka, Shuji Ohno, Takahiro Ichise, Shouta M.M. Nakayama, Mayumi Ishizuka and Nobuhiko Hoshi
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of the toxicity of DDT in wildlife focusing on sex linked gene expression2019

    • Author(s)
      Kodai Motohira, Ikenaka Y,YARED YB, Nakayama SMM , Wepener V, Smit N, Vuren JV, Ishizuka M
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the Effects of Low Dose Exposures to Imidacloprid on Hepatic Lipid Homeostasis in a C57BL/6J Mice Model2019

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atsushi KOBAYASHI, Ryo YAMAZAKI, Shouta M.M. NAKAYAMA, Mayumi ISHIZUKA
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pharmacokinetics/dynamics analysis of anticoagulant rodenticides with Egyptian fruit bats (Rousettus aegyptiacus)2019

    • Author(s)
      Kazuki Takeda, Kosuke Manago, Shouta MM Nakayama, Ayuko Morita,Yoshinori Ikenaka, and Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Species differences in cytochrome P450-mediated metabolism of polychlorinated biphenyls between cats and dogs2019

    • Author(s)
      Kraisiri KHIDKHAN, Hazuki MIZUKAWA, Makoto SHIMASAKI, Kei NOMIYAMA, Yoshinori IKENAKA, Shouta M.M. NAKAYAMA, Hisato IWATA and Mayumi ISHIZUKA
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blood Lead Levels and ALAD Promoter Methylation among Environmental Lead-Exposed Children from Kabwe, Zambia2019

    • Author(s)
      YARED B. Yohannes, Nakayama SMM, Yabe J, Toyomaki H, Kataba A, Muzandu K, Nakata H, Ikenaka Y, Choongo K, Ishizuka M
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of environmentally relevant lead (Pb) acute exposure on the locomotion behaviour and molecular subcellular responses in the larvae of Danio rerio (zebrafish).2019

    • Author(s)
      Andrew Kataba,Tarryn Lee Botha,Shota MM Nakayama,Yoshinori Ikenaka, Victor Wepener,Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Organ Pb distribution and temporal change of blood Pb concentrations with oral administration of Pb bullets in waterfowls and raptors2019

    • Author(s)
      Hiroshi SATO, Chihiro ISHII, Shouta M. M. NAKAYAMA, Takahiro ICHISE, Keisuke SAITO, Yukiko WATANABE, Kohei OGASAWARA, Ryota TORIMOTO, Atushi KOBAYASHI, Takashi KIMURA, Yoshinori IKENAKA, Mayumi ISHIZUKA
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening of metal-related toxicity in residents of Kabwe, Zambia2019

    • Author(s)
      Hokuto Nakata, Shouta MM Nakayama, John Yabe, Kaampwe Muzandu, Haruya Toyomaki, Yared B Yohannes, Andrew Kataba, Golden Zyambo, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Seabirds are exposed to chemical additives through plastic ingestion2019

    • Author(s)
      Kosuke Tanaka, Yutaka Watanuki, Hideshige Takada, Yosinori Ikenaka, Shouta Nakayama, Rei Yamashita, Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of monitoring method for neurotransmission disturbance of nicotinic acetylcholine receptor agonist ~Live imaging of cranial nerve activity using two-photon microscopy ~2019

    • Author(s)
      Anri Hirai,Shouta Sugio,Yoshinori Ikenaka, Collins Nimako,Shouta M.M. Nakayama, Nobuhiko Hoshi, Hiroaki Wake, Mayumi Ishizuka
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolution of Avian UDP-glucuronosyltransferase Genes in Relation to Feeding Habit2019

    • Author(s)
      Kawai YK, Shinya S, Nakayama SMM, Ikenaka Y, Ishizuka M, Kubota A
    • Organizer
      International Symposium on Chemical Hazard in Wildlife
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒゲ板中安定同位体比から推定するクロミンククジラ成熟雄の回遊生態2019

    • Author(s)
      石川啓史、石塚真由美、池中良徳、中山翔太、坂東武治、田村力、小西健志、大槻真友子、三谷曜子
    • Organizer
      令和2年度日本水産学会春季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gene Specific Promoter Methylation of Lead Exposure Biomarker Genes in Environmental Lead-Exposed Children from Kabwe, Zambia2019

    • Author(s)
      YARED B. Yohannes, Shouta Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Kaampwe Muzandu, Hokuto Nakata, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka
    • Organizer
      The 2020 SOT Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Potentiation of High Fat Diet-induced Diabetogenesis by Neonicotinoid Insecticides: Elucidation of the Mechanistic Pathways using In vivo Assays2019

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Yuko OKAMATSU-OGURA, Atushi KOBAYASHI, Shouta M.M. NAKAYAMA, Mayumi ISHIZUKA
    • Organizer
      International CHEMICAL HAZARD Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adverse outcome in cognitive emotional behavior of acute exposure to NOAEL neonicotinoid in mouse2019

    • Author(s)
      Nobuhiko Hoshi, Tetsushi Hirano, Yoshinori Ikenaka, Shuji Ohno, Kanoko Onaru, Shizuka Kubo, Mizuki Maeda, Yuka Miyata, Kosuke Sugita, Mayumi Ishizuka, Youhei Mantani, Toshifumi Yokoyama
    • Organizer
      International CHEMICAL HAZARD Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of the biomarker and toxicity mechanisms related to DDT exposure using wild rat2019

    • Author(s)
      Kodai Motohira, Yoshinori Ikenaka, Shouta M.M. Nakayama, Yared Beyene, Victor Wepener, Nico Smit, Johan van Vuren, Hazuki Mizukawa, Akifumi Eguchi, Ana Catarina Sousa, Mayumi Ishizuka
    • Organizer
      International CHEMICAL HAZARD Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uncertainties Associated with Neonicotinoid Insecticide`s Safety Thresholds and the Potential Ramifications on Human Health: A Case Study of Ghana2018

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Osei AKOTO, Nesta BORTEY-SAM, Shouta M.M. NAKAYAMA, Hazuki MIZUKAWA, Mayumi ISHIZUKA
    • Organizer
      2nd Chemical Hazard Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Exposure and Toxicological Implications of Neonicotinoid Insecticides among the residents of Kumasi, Ghana2018

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Osei AKOTO, Nesta BORTEY-SAM, Shouta M.M.NAKAYAMA, Hazuki MIZUKAWA and Mayumi ISHIZUKA
    • Organizer
      The 6th Sapporo Summer Symposium for One Health (6th SaSSOH)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Neonicotinoid Insecticide Exposure and Toxicity among some residents of Kumasi, Ghana2018

    • Author(s)
      Collins NIMAKO, Yoshinori IKENAKA, Osei AKOTO, Nesta BORTEY-SAM, Shouta M.M. NAKAYAMA, Hazuki MIZUKAWA and Mayumi ISHIZUKA
    • Organizer
      Society for Environmental Toxicology and Chemistry, Asia-Pacifi 2018 (SETAC-AP2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 浸透性農薬とその代謝産物の胎子移行量の解明2018

    • Author(s)
      大野周嗣、大成果乃子、久保静花、坂田奈那美、杉田晄佑、宮田結佳、高田匡、平野哲史、万谷洋平、横山俊史、石塚真由美、池中良徳、星信彦
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネオニコチノイド系殺虫剤のヒト健康影響評価問題点の整理と今後の研究課題2018

    • Author(s)
      池中良徳、一瀬貴大、ニマコ コリンズ、市川剛、水川葉月、中山翔太、有薗幸司、石塚真由美
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evaluation of Neonicotinoid Insecticide exposure in humans living in the Kumasi city, Ghana2018

    • Author(s)
      Collins Nimako, Yoshinori Ikenaka, Osei Akoto, Nesta Bortey-Sam, Shouta M.M. Nakayama, Hazuki Mizukawa, and Mayumi Ishizuka
    • Organizer
      第27回環境化学討論会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 北海道大学One Health Research Center

    • URL

      https://ohrc.vetmed.hokudai.ac.jp/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究院附属動物病院トランスレーショナルリサーチ推進室

    • URL

      https://www.hokudai-vet-tr-unit.com/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究院環境獣医科学分野毒性学教室

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究院 毒性学教室 ホームページ

    • URL

      http://tox.vetmed.hokudai.ac.jp/

    • Related Report
      2020 Annual Research Report 2018 Annual Research Report
  • [Remarks] 北海道大学大学院獣医学研究院 毒性学教室 ホームページ

    • URL

      http://tox.vetmed.hokudai.ac.jp/research/presentations

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] Chemical Hazard Symposium 20222022

    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] 4th International Toxicology Symposium2021

    • Related Report
      2020 Annual Research Report
  • [Funded Workshop] International Symposium on Chemical Hazard in Wildlife2020

    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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