| Budget Amount *help |
¥512,720,000 (Direct Cost: ¥394,400,000、Indirect Cost: ¥118,320,000)
Fiscal Year 2022: ¥96,200,000 (Direct Cost: ¥74,000,000、Indirect Cost: ¥22,200,000)
Fiscal Year 2021: ¥112,970,000 (Direct Cost: ¥86,900,000、Indirect Cost: ¥26,070,000)
Fiscal Year 2020: ¥121,160,000 (Direct Cost: ¥93,200,000、Indirect Cost: ¥27,960,000)
Fiscal Year 2019: ¥109,850,000 (Direct Cost: ¥84,500,000、Indirect Cost: ¥25,350,000)
Fiscal Year 2018: ¥72,540,000 (Direct Cost: ¥55,800,000、Indirect Cost: ¥16,740,000)
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| Outline of Final Research Achievements |
We investigated the regulatory mechanism of p57, a cell cycle regulator specifically expressed in adult stem cells (ASCs), at the chromatin level and found that it is regulated by enhancers in adjacent genes. We also found that p57-positive cells in intestinal and gastric ASCs undergo complex reprogramming and that their properties change drastically between normal and injured states. Furthermore, ablation of p57-positive cells in colon cancer stem cells (CSCs) markedly suppressed cancer recurrence.
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| Assessment Rating |
Ex-post Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.
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Assessment Rating |
Interim Assessment Comments (Rating)
A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.
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