A study on nausea and clay eating in rats
| Project/Area Number |
18K03192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 10040:Experimental psychology-related
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| Research Institution | Kwansei Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 悪心 / 異食 / カオリン粘土 / ラット / 走行 / 水泳 / 味覚嫌悪学習 / 性差 / 連合学習 / 条件づけ / マウス / カオリン / 粘土食 / 乳糖 / 回転かご走行 / パイカ行動 / 運動 |
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| Outline of Final Research Achievements |
Rats, the standard laboratory animal, are incapable of vomiting for neurological and muscular reasons. However, when rats are subjected to procedures that induce nausea in humans, such as administration of emetics or irradiation, they exhibit pica behavior (i.e., eating kaolin clay). Therefore, clay eating has been considered an indicator of nausea. In this study, the function and characteristics of clay eating were investigated using experimental methods of behavioral psychology, and it was revealed that physical exercise such as running and swimming and lactose intake also produce clay eating, suggesting that exercise and lactose intake induce nausea. Furthermore, I found that emetics cause ingestion of zeolite clay, gypsum, and lime, in addition to kaolin clay, albeit to a lesser extent. Gender differences in clay eating were also examined.
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| Academic Significance and Societal Importance of the Research Achievements |
ラットの異食行動は抗癌研究の分野において、治療処置（その多くは悪心を副作用として有する）の嫌悪度測定法として注目されてきたが、催吐処置を用いてラットの味覚嫌悪学習を研究する実験心理学者にとって、異食行動を指標とした悪心測定は未活用の方法であった。本研究の成果は「動物の心の可視化技術」の一つとして今後発展が期待できる。なお、本研究で行ったカオリン粘土以外の鉱物を異食のテスト材料とする試みや、異食に関する性差の検討は、癌の治療処置の嫌悪度に関する基礎研究の方法論の改善に資するであろう。
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Report
(6 results)
Research Products
(28 results)
