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A study on nausea and clay eating in rats

Research Project

Project/Area Number 18K03192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionKwansei Gakuin University

Principal Investigator

NAKAJIMA Sadahiko  関西学院大学, 文学部, 教授 (40299045)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords悪心 / 異食 / カオリン粘土 / ラット / 走行 / 水泳 / 味覚嫌悪学習 / 性差 / 連合学習 / 条件づけ / マウス / カオリン / 粘土食 / 乳糖 / 回転かご走行 / パイカ行動 / 運動
Outline of Final Research Achievements

Rats, the standard laboratory animal, are incapable of vomiting for neurological and muscular reasons. However, when rats are subjected to procedures that induce nausea in humans, such as administration of emetics or irradiation, they exhibit pica behavior (i.e., eating kaolin clay). Therefore, clay eating has been considered an indicator of nausea. In this study, the function and characteristics of clay eating were investigated using experimental methods of behavioral psychology, and it was revealed that physical exercise such as running and swimming and lactose intake also produce clay eating, suggesting that exercise and lactose intake induce nausea. Furthermore, I found that emetics cause ingestion of zeolite clay, gypsum, and lime, in addition to kaolin clay, albeit to a lesser extent. Gender differences in clay eating were also examined.

Academic Significance and Societal Importance of the Research Achievements

ラットの異食行動は抗癌研究の分野において、治療処置(その多くは悪心を副作用として有する)の嫌悪度測定法として注目されてきたが、催吐処置を用いてラットの味覚嫌悪学習を研究する実験心理学者にとって、異食行動を指標とした悪心測定は未活用の方法であった。本研究の成果は「動物の心の可視化技術」の一つとして今後発展が期待できる。なお、本研究で行ったカオリン粘土以外の鉱物を異食のテスト材料とする試みや、異食に関する性差の検討は、癌の治療処置の嫌悪度に関する基礎研究の方法論の改善に資するであろう。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (17 results) (of which Peer Reviewed: 15 results,  Open Access: 9 results) Presentation (11 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Pica caused by emetic drugs in laboratory rats with kaolin, gypsum, and lime as test substances2023

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      Physiology & Behavior

      Volume: 261 Pages: 114076-114076

    • DOI

      10.1016/j.physbeh.2023.114076

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 実験用ラットの食の好みに関する探索的研究2022

    • Author(s)
      中島定彦・松房美穂・藤戸彩花・遠藤稔也・山下ひかる・山下玲子・小山加那子・九重智咲・辻桃奈・名和明日香
    • Journal Title

      関西学院大学心理科学研究

      Volume: 48 Pages: 1-15

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] 実験用マウスとラットの食の好みに関する研究―チーズに代わる魅力的な餌を探る―2022

    • Author(s)
      中島定彦
    • Journal Title

      人文論究(関西学院大学)

      Volume: 72(2) Pages: 27-45

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Food avoidance learning based on entirely voluntary wheel running in laboratory mice (Mus musculus)2021

    • Author(s)
      Sadahiko Nakajima
    • Journal Title

      Behavioural Processes

      Volume: 192 Pages: 104484-104484

    • DOI

      10.1016/j.beproc.2021.104484

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kaolin clay intake motivated by lactose ingestion in rats2021

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      Learning and Motivation

      Volume: 74 Pages: 101724-101724

    • DOI

      10.1016/j.lmot.2021.101724

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Taste aversion learning based on swimming and lithium chloride injection in rats: Implications from cross‐familiarization tests and stimulus selectivity2020

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      Japanese Psychological Research

      Volume: 63 Issue: 2 Pages: 72-84

    • DOI

      10.1111/jpr.12281

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of pretrial running on running-based taste aversion learning in rats.2020

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      Journal of Experimental Psychology: Animal Learning and Cognition

      Volume: 46 Issue: 3 Pages: 273-285

    • DOI

      10.1037/xan0000243

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Flavor aversion learning based on running: A review2020

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      International Journal of Comparative Psychology

      Volume: 33 Pages: 48126-48126

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Further evidence for swimming‐based pica in rats2020

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      Japanese Psychological Research

      Volume: 62 Issue: 1 Pages: 39-50

    • DOI

      10.1111/jpr.12243

    • NAID

      210000171851

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring rats’ nausea with clay eating2019

    • Author(s)
      中島 定彦
    • Journal Title

      The Japanese Journal of Psychonomic Science

      Volume: 38 Issue: 1 Pages: 137-142

    • DOI

      10.14947/psychono.38.21

    • NAID

      130007760487

    • ISSN
      0287-7651, 2188-7977
    • Year and Date
      2019-09-30
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Further demonstration of running-based food avoidance learning in laboratory mice (Mus musculus)2019

    • Author(s)
      Nakajima Sadahiko
    • Journal Title

      Behavioural Processes

      Volume: 168 Pages: 103962-103962

    • DOI

      10.1016/j.beproc.2019.103962

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Food avoidance learning based on voluntary wheel running in laboratory mice (Mus musculus). Behavioural Processes2019

    • Author(s)
      Nakajima, S.
    • Journal Title

      Behavioural Processes

      Volume: 159 Pages: 31-39

    • DOI

      10.1016/j.beproc.2018.12.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Food aversion learning based on voluntary running in non-deprived rats: a technique for establishing aversive conditioning with minimized discomfort2019

    • Author(s)
      Nakajima, S.
    • Journal Title

      Experimental Animals

      Volume: 68 Issue: 1 Pages: 71-79

    • DOI

      10.1538/expanim.18-0075

    • NAID

      130007604508

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clay eating attenuates lithium-based taste aversion learning in rats: A remedial effect of kaolin on nausea.2018

    • Author(s)
      Nakajima, S.
    • Journal Title

      Physiology & Behavior

      Volume: 188 Pages: 199-204

    • DOI

      10.1016/j.physbeh.2018.02.020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Running-based pica and taste avoidance in rats2018

    • Author(s)
      Nakajima, S.
    • Journal Title

      Learning & Behavior

      Volume: 46 Issue: 2 Pages: 182-197

    • DOI

      10.3758/s13420-017-0301-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of water temperature on swimming-based taste aversion learning in rats2018

    • Author(s)
      Nakajima, S.
    • Journal Title

      Learning and Motivation

      Volume: 63 Pages: 91-97

    • DOI

      10.1016/j.lmot.2018.02.001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extinction of running-based taste aversion in rats (Rattus norvegicus).2018

    • Author(s)
      Nakajima, S.
    • Journal Title

      International Journal of Comparative Psychology

      Volume: 31

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Nauseated rats ingest gypsum and lime in addition to kaolin clay, but only to a lesser extent2022

    • Author(s)
      Nakajima Sadahiko
    • Organizer
      Europhysiology 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 阻止効果(blocking effect)の普遍性と頑健性について2019

    • Author(s)
      中島定彦
    • Organizer
      日本心理学会第83回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ラットの走行性味覚嫌悪学習における阻止効果検出の試み2019

    • Author(s)
      長谷川依保・中島定彦
    • Organizer
      日本心理学会第83回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Establishing aversive conditioning in rats and mice with minimized discomfort2019

    • Author(s)
      Nakajima, S.
    • Organizer
      The 58th Annual Convention of the Taiwan Psychological Association
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Associative blocking effect on running-based taste aversion learning in rats2019

    • Author(s)
      Hasegawa, I., & Nakajima, S.
    • Organizer
      日本動物心理学会第79回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ラットは悪心を感じると石膏も食べる2019

    • Author(s)
      中島定彦
    • Organizer
      日本基礎心理学会第38回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Running-based taste aversion learning in mice2018

    • Author(s)
      Nakajima, S.
    • Organizer
      The 126th Annual Convention of the American Psychological Association
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 味覚嫌悪学習を知る―ラットの行動研究から―2018

    • Author(s)
      中島定彦
    • Organizer
      日本行動分析学会第36回年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] マウスにおける走行性味覚嫌悪学習2018

    • Author(s)
      中島定彦
    • Organizer
      日本心理学会第82回大会ポスター発表
    • Related Report
      2018 Research-status Report
  • [Presentation] 嫌悪処置なしで形成するラットの味覚嫌悪学習2018

    • Author(s)
      中島定彦
    • Organizer
      日本心理学会第82回大会公募シンポジウムでの話題提供
    • Related Report
      2018 Research-status Report
  • [Presentation] ラットは腹具合が悪いと土を喰うか―乳糖不耐症の場合―2018

    • Author(s)
      中島定彦
    • Organizer
      日本基礎心理学会第32回大会ポスター発表
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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