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Estimation of dose distribution using luminesence of water during proton beam irradiation -discrimination with Cherenkov light-

Research Project

Project/Area Number 18K04974
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 30020:Optical engineering and photon science-related
Research InstitutionNagoya University

Principal Investigator

Komori Masataka  名古屋大学, 医学系研究科(保健), 准教授 (30392228)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords水の発光 / 微弱光 / チェレンコフ光 / 陽子線治療 / 線量分布推定 / QA/QC / 水の発光現象 / イメージング / 医学物理学
Outline of Final Research Achievements

This study aimed to clarify the difference in the angular dependence of luminescence and Cherenkov light emitted from water during proton beam irradiation. The proton beam energy used was 100 MeV, emitting only luminescence, and 200 MeV, emitting both luminescence and Cherenkov light. The Monte Carlo simulation: Geant4 also calculated the angular dependence.
Both measurements and calculations showed that the luminescence emitted almost isotropically, while the Cherenkov light emitted strongly in the forward direction. The difference in the angular dependence suggests that luminescence and Cherenkov light are distinguishable.

Academic Significance and Societal Importance of the Research Achievements

100 MeV陽子線照射の発光量分布から微弱光はほぼ等方的に発光していることが明らかとなった。一方で、200 MeV陽子線照射の発光量分布からチェレンコフ光は前方に強く発光していることが分かった。チェレンコフ光の発光量分布は既知の物理学で計算可能である。従って微弱光とチェレンコフ光が混在する発光量分布から計算で得られたチェレンコフ光の分布を差分することで、微弱光分布のみが得られることが示唆された。これにより、微弱光分布を用いた簡便かつ高精度な線量分布推定法への応用が可能であることが分かった。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (35 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (17 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results) Presentation (18 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Luminescence imaging of water irradiated by protons under FLASH radiation therapy conditions2023

    • Author(s)
      Katsunori Yogo, Satoshi Kodaira, Tamon Kusumoto, Hisashi Kitamura, Toshiyuki Toshito, Hiromitsu Iwata, Masumi Umezawa, Masashi Yamada, Takuto Miyoshi, Masataka Komori
    • Journal Title

      Physics in Medicine and Biology.

      Volume: 68 Issue: 15 Pages: 15NT02-15NT02

    • DOI

      10.1088/1361-6560/ace60b

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Planning strategies for robust carbon-ion scanning radiotherapy for stage I esophageal cancer: a retrospective study2023

    • Author(s)
      Suga Makito、Kusano Yohsuke、Takakusagi Yosuke、Oosawa Yukio、Minohara Shinichi、Yoshida Daisaku、Katoh Hiroyuki、Kamada Tadashi、Komori Masataka
    • Journal Title

      Journal of Radiation Research

      Volume: 64 Issue: 5 Pages: 816-823

    • DOI

      10.1093/jrr/rrad057

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an x-ray-opaque-marker system for quantitative phantom positioning in patient-specific quality assurance2021

    • Author(s)
      Kentaro Suzuki, Takeshi Kamomae, Hiroshi Oguchi, Fumitaka Kawabata, Kazuma Sugita, Kuniyasu Okudaira, Masaki Mori, Shinji Abe, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Yoshiyuki Itoh, Shinji Naganawa
    • Journal Title

      Phys Med

      Volume: 91 Pages: 121-130

    • DOI

      10.1016/j.ejmp.2021.10.017

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] MEASUREMENT OF HALF-VALUE LAYER IN COMPUTED TOMOGRAPHY SCANNERS USING LUMINESCENCE OF POLYETHERSULFONE RESIN BY X-RAY IRRADIATION2021

    • Author(s)
      Yamauchi-Kawaura C、Maki E、Fujii K、Komori M、Imai K
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 196 Issue: 1-2 Pages: 26-33

    • DOI

      10.1093/rpd/ncab126

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the angular distribution of produced light in water during high-energy proton irradiation2021

    • Author(s)
      Ushiba Hiroto、Komori Masataka、Kitao Yohei、Toshito Toshiyuki
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 41 Sup.1 Pages: 41-41

    • Related Report
      2020 Research-status Report
  • [Journal Article] Radioluminescence by synchrotron radiation with lower energy than the Cherenkov light threshold in water2020

    • Author(s)
      Hirano Yoshiyuki、Komori Masataka、Onoda Daichi、Nagae Takayuki、Yamamoto Seiichi
    • Journal Title

      Journal of Physics Communications

      Volume: 4 Issue: 7 Pages: 075002-075002

    • DOI

      10.1088/2399-6528/ab9f8d

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measurements of temporal response of luminescence of water at lower energy than Cerenkov-light threshold during carbon-ion irradiation2020

    • Author(s)
      Yamamoto Seiichi、Akagi Takashi、Hirano Yoshiyuki、Komori Masataka
    • Journal Title

      Biomedical Physics & Engineering Express

      Volume: 6 Issue: 4 Pages: 045002-045002

    • DOI

      10.1088/2057-1976/ab8b7e

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Study for angular dependences of luminescence and Cherenkov light of water for dose estimation of therapeutic proton beam2020

    • Author(s)
      Komori Masataka、Kitao Yohei、Onoda Daichi、Toshito Toshiyuki、Hirano Yoshiyuki
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 40 Sup.1 Pages: 65-65

    • Related Report
      2019 Research-status Report
  • [Journal Article] Spectrum measurement of luminescence of water by synchrotron radiation beam with lower energy than the Cerenkov-light threshold2020

    • Author(s)
      Hirano Yoshiyuki、Komori Masataka、Kitao Yohei、Onoda Daichi、Yamamoto Seiichi
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 40 Sup.1 Pages: 94-94

    • Related Report
      2019 Research-status Report
  • [Journal Article] Imaging of fragment particles in water by nuclear spallation during carbon-ion irradiation2019

    • Author(s)
      Yabe Takuya、Komori Masataka、Akagi Takashi、Yamashita Tomohiro、Yamamoto Seiichi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 64 Issue: 13 Pages: 13NT01-13NT01

    • DOI

      10.1088/1361-6560/ab2920

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] OPTIMIZATION OF AN ADDITIONAL COLLIMATOR IN A BEAM DELIVERY SYSTEM FOR REDUCTION OF THE SECONDARY NEUTRON EXPOSURE IN PASSIVE CARBON-ION THERAPY2019

    • Author(s)
      Komori Masataka、Takeuchi Akihiko、Niwa Maiko、Harada Takaomi、Oguchi Hiroshi
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 184 Issue: 1 Pages: 28-35

    • DOI

      10.1093/rpd/ncy182

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional (3D) dose distribution measurements of proton beam using a glass plate2019

    • Author(s)
      Horita Ryo、Yamamoto Seiichi、Yogo Katsunori、Komori Masataka、Toshito Toshiyuki
    • Journal Title

      Biomedical Physics & Engineering Express

      Volume: 5 Issue: 4 Pages: 045033-045033

    • DOI

      10.1088/2057-1976/ab169e

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of the three-dimensional (3D) dose distribution of electron beams from medical linear accelerator (LINAC) using plastic scintillator plate2019

    • Author(s)
      Horita Ryo、Yamamoto Seiichi、Yogo Katsunori、Hirano Yoshiyuki、Okudaira Kuniyasu、Kawabata Fumitaka、Nakaya Takayoshi、Komori Masataka、Oguchi Hiroshi
    • Journal Title

      Radiation Measurements

      Volume: 124 Pages: 103-108

    • DOI

      10.1016/j.radmeas.2019.04.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Discovery of scintillation of float glass and application for 3D dose distribution measurements of proton beam2019

    • Author(s)
      Yamamoto Seiichi, Horita Ryo, Yogo Katsunori, Komori Masataka, Toshito Toshiyuki
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 39 Sup.3 Pages: 30-30

    • Related Report
      2019 Research-status Report
  • [Journal Article] Estimation and correction of Cerenkov-light in the luminescence image of water during irradiations2019

    • Author(s)
      Yabe Takuya、Hirano Yoshiyuki、Komori Masataka、Akagi Takashi、Yamamoto Seiichi
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 39 Sup.3 Pages: 24-24

    • Related Report
      2019 Research-status Report
  • [Journal Article] Comparison between luminescence and dose in water during uniform-field irradiation by spot scanning proton beam2019

    • Author(s)
      Masataka Komori, Eri Sekihara, Takuya Yabe, Ryo Horita, Toshiyuki Toshito, Seiichi Yamamoto
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 39 Sup.1 Pages: 197-197

    • Related Report
      2018 Research-status Report
  • [Journal Article] Measurements of the propagation difference between Cherenkov-light and luminescence of water during carbon-ion beam irradiation2019

    • Author(s)
      Yohei Kitao, Masataka Komori, Ryo Horita, Fumitaka Kawabata, Kazuma Sugita, Kuniyasu Okudaira, Hiroshi Oguchi, Seiichi Yamamoto
    • Journal Title

      Japanese Journal of Medical Physics

      Volume: 39 Sup.1 Pages: 198-198

    • Related Report
      2018 Research-status Report
  • [Presentation] 水への陽子線照射時に発生するチェレンコフ光と微弱光の角度依存性のシミュレーション2023

    • Author(s)
      星野晃希, 小森雅孝, 平松夢翔, 歳藤利行
    • Organizer
      第51回日本放射線技術学会秋季学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] コリメータを用いた頭部陽子線スキャニング照射での中性子被ばく線量を評価する簡易推定モデルの作成2023

    • Author(s)
      大野聖弥, 小森雅孝, 小林勇太, 歳藤利行
    • Organizer
      第51回日本放射線技術学会秋季学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Roos型平行平板形電離箱における体積平均効果の評価2023

    • Author(s)
      矢谷朋子, 小口宏, 小林勇太, 奥平訓康, 清水秀年, 加茂前健, 小森雅孝
    • Organizer
      第51回日本放射線技術学会秋季学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Evaluating nanoparticle candidates as radiation modifiers on DNA damages for radiation therapy2023

    • Author(s)
      AOYAMA Kanako, YOGO Katsunori, KOMORI Masataka
    • Organizer
      Nagoya-Yonsei University Research Exchange Meeting on Health Sciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微弱光を用いた治療用陽子線の線量分布推定 -Geant4 を用いたチェレンコフ光除去による精度向上-2022

    • Author(s)
      平松夢翔、小林勇太、星野晃希、歳藤利行、小森雅孝
    • Organizer
      第14回中部放射線医療技術学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Evaluation of dose equivalent by secondary neutrons generated by head proton therapy2022

    • Author(s)
      KOBAYASHI Yuta, KOMORI Masataka, TOSHITO Toshiyuki
    • Organizer
      第123回日本医学物理学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Evaluation of the angular distribution of produced light in water during high-energy proton irradiation2021

    • Author(s)
      Ushiba Hiroto、Komori Masataka、Kitao Yohei、Toshito Toshiyuki
    • Organizer
      第121回日本医学物理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effects of parallax error and light refraction on estimation for dose distribution of proton beams using luminescence in water2020

    • Author(s)
      Furuo Koki、Komori Masataka、Ushiba Hiroto、Toshito Toshiyuki
    • Organizer
      20th Asia-Oceania Congress on Medical Physics
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduction of parallax-error effect to luminescence imaging of water for dose estimation of therapeutic proton beam2020

    • Author(s)
      Komori Masataka、Senga Ken-ichiro、Kitao Yohei、ToshitoToshiyuki
    • Organizer
      European Congress of Radiology (ECR) 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study for angular dependences of luminescence and Cherenkov light of water for dose estimation of therapeutic proton beam2020

    • Author(s)
      Komori Masataka、Kitao Yohei、Onoda Daichi、Toshito Toshiyuki、Hirano Yoshiyuki
    • Organizer
      第119回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Spectrum measurement of luminescence of water by synchrotron radiation beam with lower energy than the Cerenkov-light threshold2020

    • Author(s)
      Hirano Yoshiyuki、Komori Masataka、Kitao Yohei、Onoda Daichi、Yamamoto Seiichi
    • Organizer
      第119回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高分子材料の微弱発光を利用したX線CT検査の実効エネルギー測定法の開発2019

    • Author(s)
      川浦稚代、牧英里奈、藤井啓輔、小森雅孝、今井國治、池田充
    • Organizer
      日本放射線技術学会第47回秋季学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Discovery of scintillation of float glass and application for 3D dose distribution measurements of proton beam2019

    • Author(s)
      Yamamoto Seiichi, Horita Ryo, Yogo Katsunori, Komori Masataka, Toshito Toshiyuki
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Estimation and correction of Cerenkov-light in the luminescence image of water during irradiations2019

    • Author(s)
      Yabe Takuya、Hirano Yoshiyuki、Komori Masataka、Akagi Takashi、Yamamoto Seiichi
    • Organizer
      第118回日本医学物理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 陽子線一様照射野における水の微弱光と線量分布の比較2019

    • Author(s)
      小森雅孝, 關原恵理, 矢部卓也, 堀田遼, 歳藤利行, 山本誠一
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 炭素線照射におけるチェレンコフ光と水の発光の伝搬の違いの評価2019

    • Author(s)
      北尾洋平, 小森雅孝, 堀田遼, 川端文隆, 杉田和真, 奥平訓康, 小口宏, 山本誠一
    • Organizer
      第117回日本医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 陽子線、炭素線及びネオン線照射による水の発光効率のLET依存性2018

    • Author(s)
      小森雅孝, 平野祥之, 矢部卓也, 堀田遼, 米内俊祐, 歳藤利行, 山本誠一
    • Organizer
      日本放射線技術学会第46回秋季学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 陽子線照射による水の発光現象においてのCCDカメラの視差誤差のない計測2018

    • Author(s)
      堀田遼, 小森雅孝, 矢部卓也, 小口宏, 山本誠一, 歳藤利行
    • Organizer
      日本放射線技術学会第46回秋季学術大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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