Synthesis of dinuclear iron complex with dioxygen activation ability
| Project/Area Number |
18K05142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 二核鉄ペルオキソ錯体 / 酸素分子活性化 / C-H結合酸化 / 機能モデル / 反応中間体 / 酸化反応 / 二核鉄(III)ペルオキソ錯体 / 二核コバルト(III)ペルオキソ錯体 / ミカエリスメンテン型 / 可逆的酸素分子吸脱着 / キャビティー / 外部基質の酸化 / C-H結合活性化 / X線結晶構造解析 / C=C結合酸化 / アレーン水酸化 / 二核化配位子 / 非ヘム型二核鉄酸化酵素 / アルカン類の酸化 / アレーン類の酸化 |
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| Outline of Final Research Achievements |
Dinuclear nonheme iron enzymes such as soluble methane monooxygenase (sMMO) and toluene monooxygenases (TMO) are responsible for C-H bond oxidation. In catalytic cycles of these enzymes, (peroxo)diiron(III) intermediates have been spectroscopically characterized as key intermediates, which show electrophilic and nucleophilic reactivity. Several (peroxo)diiron(III) complexes have been synthesized as structural and spectroscopical models, however only a few functional models have been reported where the peroxodiiron(III) complexes show oxidation reactivity. In this study, (peroxo)diiron(III) complexes were synthesized and their oxidation ability towards external substrates were studied.
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| Academic Significance and Societal Importance of the Research Achievements |
酸素分子を酸化剤として用いたアルカンやアレーン類の水酸化は現代化学で最も難しく重要な酸化反応のひとつである。メタンのメタノールへの水酸化やクメン法にかわるフェノールの合成は，世界でチャレンジすべき触媒反応１０（1993年時点）にリストアップされているが，生体系のメタンモノオキシゲナーセ（MMO: 2Fe, nCu）やトルエンモノオキシゲナーゼ（TMO: 2Fe）のように酸素分子を活性化し，有機基質を酸化できる物質の報告例はほとんどない。したがって本研究は，多くの研究者が関心を持つ研究課題であり，酸素分子を活性化能を有する物質を合成する意義は大きい。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Crystal Structure of Bis(μ-hydroxo)diiron(II) Complex with a Dinucleating Ligand Having a Butyl Linker2019
Author(s)
M. Sekino, H. Furutachi, K. Tasaki, T. Ishikawa, S. Fujinami, S. Akine, Y. Sakata, M. Suzuki, T. Nomura, T. Ogura, and T. Kitagawa
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Journal Title
X-ray Structure Analysis Online
Volume: 35
Issue: 0
Pages: 5-7
DOI
NAID
ISSN
1883-3578
Year and Date
2019-02-10
Related Report
Peer Reviewed / Open Access
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