| Project/Area Number |
18K05146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 絶対自然分晶 / キラリティ / ランタノイド / 多核錯体 / ホモキラル集積 / 完全自然分晶 |
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| Outline of Final Research Achievements |
This study was aimed to elucidate the mechanism of absolute spontaneous resolution, in which only optically active crystals with a specific chirality are always deposited on crystallization. The target compounds were the trinuclear metal complex salts consisting of non-optically active tripodal organic ligands, transition and lanthanoid metal ions, counter anion, and some solvent molecules of crystallization. We have examined the difference in crystallization behavior under different combination of metal ions, counter anions, and crystallization conditions including the solvents. It was confirmed that the numbers of d- and f-electrons of transition and lanthanoid ions, respectively, contribute to the definitive effect of this peculiar crystallization behavior. In addition, it was revealed that a normal homochiral recognition occurred on the crystal surface of these compounds and crystal chirality could be induced on crystallization.
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| Academic Significance and Societal Importance of the Research Achievements |
自然界及びそこに生きる生命体が片方の鏡像体のみで形成されていることはよく知られた事実であるが、そのキラリティがどのように発現したのかは、現代科学の重要な未解決問題の一つである。本研究において、光学活性源を含まない材料から生成する結晶性化合物に自発的なキラリティ発現が生じる原因を解明する事ができれば、その学術的な意義は基礎化学に限らず、あらゆる自然科学分野において非常に大きい。また、生成するキラル結晶から有用な固体触媒を開発できれば、光学活性源を必要としない完全不斉合成を達成する可能性が生まれ、精密医薬品合成をはじめとする化学工業界に与える社会的な意義も大きい。
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