Development of Ion-sensing Membranes Modified Chemically with Biocompatible Materials for Analysis of Biological Samples
| Project/Area Number |
18K05172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Wakayama University |
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Principal Investigator |
YAJIMA Setsuko 和歌山大学, システム工学部, 教授 (80272350)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | イオン感応膜 / スルホベタイン誘導体 / 化学結合 / 生体適合性 / センサー性能 / 化学修飾 / 生体適合性化合物 |
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| Outline of Final Research Achievements |
Ion sensors are used for determination of ion concentrations. Since the ion-sensing membranes are less biocompatible, it is necessary to prepare the membranes consisting of biocompatible materials in order to use them for analysis of biological samples.
In this study, I have prepared ion-sensing membranes whose surfaces were chemically modified with sulfobetaine derivatives as biocompatible materials.
The membranes showed good sensor properties, which are comparable to conventional membranes, and improved biocompatibility.
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| Academic Significance and Societal Importance of the Research Achievements |
イオンセンサーは，溶液中のイオン濃度の定量が可能な装置で，様々な優れた性能を示すため，臨床分析において血液の分析に使用されている。しかし，その感応部分が生体適合性に乏しいため，タンパク質などの付着により次第に性能が低下する。それを防ぐために通常は前処理などの煩雑な作業を行うために余分な時間がかかっている。本研究で開発した生体適合性の感応膜を用いれば，生体由来物質の付着が防げるため，より迅速に臨床分析の結果を得ることが可能になる。
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Report
(4 results)
Research Products
(5 results)
