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Elucidation of the intestinal microbiota that affect the absorption and metabolism of flavonoids

Research Project

Project/Area Number 18K05528
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

Tamura Motoi  国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 主席研究員 (70353943)

Co-Investigator(Kenkyū-buntansha) 中川 博之  国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 上級研究員 (30308192)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsケルセチン / レスベラトロール / 腸内菌叢 / ケルセチン分解菌 / 腸内環境 / 腸内細菌 / マウス
Outline of Final Research Achievements

Intestinal microbiota is thought to play an important role in the bioavailability of quercetin. Therefore, we investigated the effects of administration of quercetin-degrading bacteria and resveratrol on quercetin metabolism and absorption in mice. The quercetin plus resveratrol diet resulted in significantly higher quercetin concentrations in the cecal contents of mice than the quercetin diet. Mice treated with resveratrol and quercetin-degrading bacteria showed significantly higher plasma quercetin metabolite concentrations than mice treated with quercetin-degrading bacteria. Consumption of resveratrol together with quercetin showed the possibility of enhancing the absorption of quercetin.

Academic Significance and Societal Importance of the Research Achievements

本研究で、ケルセチン分解菌19-20株のマウスへの投与が、マウスの内蔵脂肪蓄積を低減させる効果を有することを見出した。ケルセチン分解菌の機能性については、詳しく研究されてこなかったが、本研究により、ケルセチン分解菌の機能性の一端を解明することが出来た。また、レスベラトロールがケルセチン分解菌のケルセチンの分解を抑制する等の効果によって、ケルセチンの吸収を高める可能性が示された。本研究は、腸内菌叢の代謝に注目することでフラボノイドの新しい機能性を見出した研究であると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2021 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Plasma quercetin metabolites are affected by intestinal microbiota of human microbiota-associated mice fed with a quercetin-containing diet2019

    • Author(s)
      Tamura M, Nakagawa H, Hori S, Suzuki T, Hirayama K.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 65 Issue: 3 Pages: 232-239

    • DOI

      10.3164/jcbn.19-45

    • NAID

      130007740758

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ケルセチン代謝菌”Bacterium 19-20”のヒトフローラマウスに及ぼす影響2021

    • Author(s)
      田村基、平山和宏
    • Organizer
      日本無菌生物ノートバイオロジー学会 第54回
    • Related Report
      2020 Annual Research Report
  • [Book] 腸内環境改善食物繊維の技術と市場2019

    • Author(s)
      田村 基 (他)
    • Total Pages
      252
    • Publisher
      シーエムシー出版
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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