Effect of dietary AGEs on RAGE-mediated signal transduction
| Project/Area Number |
18K05544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
Kobori Toshiro 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 上級研究員 (10353971)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 終末糖化産物 / 加齢性疾患 / 食品加工 |
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| Outline of Final Research Achievements |
Advanced Glycation End products (AGEs) are a group of amino acids modifications produced with sugars or di-carbonyls, and some AGEs are known to affect health through binding to receptor of AGEs (RAGE). To clarify if peptide-linked AGEs could reduce cellular inflammation through RAGE triggered by protein-linked AGEs, RAGE-binding and cellular effect of protein- and peptide-linked AGEs were analyzed. Superoxide anion was produced in HUVEC upon AGEs, and the production level was correlated with its RAGE binding activity. Proteolysis of protein-linked AGEs reduced its RAGE-binding activity. Furthermore, superoxide anion production by protein-linked AGEs was reduced by adding peptide-linked AGEs to the culture medium. These results suggest that RAGE-mediated signal transduction by intrinsic AGEs might be reduced by dietary AGEs.
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| Academic Significance and Societal Importance of the Research Achievements |
ペプチド型の食事性AGEsもタンパク質型の内因性AGEsと同様にRAGEを介した加齢性疾患の一因とする考え方が一般的だが、タンパク質型AGEsとペプチド型AGEsが共存する環境では、前者によるRAGEを介した生体影響が後者によって緩和され、RAGEを契機としたシグナル伝達がAGEsの存在形態によって変動する可能性が示唆された。引き続き検討は必要だが、得られた成果は内因性AGEsの多寡に応じた食生活改善に活用できる知見となる可能性がある。
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Report
(2 results)
Research Products
(2 results)
