Effects of immunological dynamics on bovine intramuscular adipogenesis

• Project/Area Number: 18K05958
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42010:Animal production science-related
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: Yamada Tomoya 国立研究開発法人農業・食品産業技術総合研究機構, 中央農業研究センター, 上級研究員 (80343987)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 栄養・飼養 / 肥育牛 / 脂肪細胞 / 筋肉内脂肪組織 / ウシ / 肥育 / 栄養飼養

Outline of Final Research Achievements

In this study, we investigated the effects of adipose tissue inflammation and senescence state on bovine intramuscular adipogenesis. We showed that the senescent state of visceral adipose tissue in Japanese black cattle was higher than that of subcutaneous adipose tissue. Our results indicated that that breed differences between Japanese black cattle and Holsteins affect the macrophage infiltration and senescence state in visceral adipose tissue. In addition, we showed that that highly marbled Japanese black cattle have a lower percentage of visceral fat. These results suggest that visceral adipose tissue inflammation and senescent state affect the bovine intramuscular adipogenesis.

Academic Significance and Societal Importance of the Research Achievements

牛肉生産では、ロース部位における筋肉内脂肪組織の蓄積が重要視されており、特に黒毛和種肥育牛は、筋肉内脂肪の蓄積能力が高いことが特徴である。本研究において、内臓脂肪における免疫細胞を介した組織炎症と組織老化が、黒毛和種肥育牛における筋肉内脂肪蓄積を制御する要因あること、さらにウシ品種差における筋肉内脂肪蓄積能力にも、これら内臓脂肪の炎症及び老化状態が影響していることが明らかとなった。本研究において得られた成果は、黒毛和種肥育牛における脂肪交雑向上のための飼養管理技術改善に繋がる新たな知見であり、さらにヒト肥満における異所性脂肪蓄積増加の要因解明にも寄与することが期待される。

Research Products

• [Journal Article] Fat depot‐specific effects of body fat distribution and adipocyte size on intramuscular fat accumulation in Wagyu cattle. (2020)
  • Author(s): Tomoya Yamada, Mituru Kamiya, Mikito Higuchi
  • Journal Title: Animal Science Journal Volume: 91 Issue: 1
  • DOI: 10.1111/asj.13449
  • Peer Reviewed
• [Journal Article] Breed differences in macrophage infiltration and senescence state in adipose tissues of Wagyu and Holsteins. (2020)
  • Author(s): Tomoya Yamada, Mituru Kamiya, Mikito Higuchi
  • Journal Title: Animal Science Journal Volume: 91 Issue: 1
  • DOI: 10.1111/asj.13443
  • Peer Reviewed
• [Journal Article] Gas Chromatography-Mass Spectrometry-Based Metabolomic Analysis of Wagyu and Holstein Beef (2020)
  • Author(s): Tomoya Yamada, Mituru Kamiya, Mikito Higuchi
  • Journal Title: Metabolites Volume: 10 Issue: 3 Pages: 95-95
  • DOI: 10.3390/metabo10030095
  • Peer Reviewed / Open Access
• [Journal Article] Fat depot-specific differences of macrophage infiltration and cellular senescence in obese bovine adipose tissues (2018)
  • Author(s): Tomoya Yamada, Mituru Kamiya, Mikito Higuchi, Naoto Nakanishi
  • Journal Title: Journal of Veterinary Medical Science Volume: 80 Issue: 10 Pages: 1495-1503
  • DOI: 10.1292/jvms.18-0324
  • NAID: 130007496688
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access