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Study on Novel Hereditary Gastrointestinal Cancers in Dogs

Research Project

Project/Area Number 18K05969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionGifu University

Principal Investigator

Hirata Akihiro  岐阜大学, 応用生物科学部, 助教 (30397327)

Co-Investigator(Kenkyū-buntansha) 阪口 雅弘  麻布大学, 獣医学部, 教授 (20170590)
川部 美史  岐阜大学, 応用生物科学部, 助教 (20635875)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords遺伝性疾患 / イヌ / ジャック・ラッセル・テリア / 消化管腫瘍 / 遺伝性消化管ポリポーシス / 遺伝子検査法 / 家族性大腸腺腫症 / APC遺伝子 / 遺伝子検査 / 遺伝病 / ジャックラッセルテリア / 胃腫瘍 / 大腸腫瘍
Outline of Final Research Achievements

Breed predisposition to certain diseases often provides promising clues to explore novel hereditary disorders in dogs. Since the late 2000s, the prevalence of gastrointestinal (GI) neoplastic polyps in Jack Russell Terriers (JRTs) has increased in Japan. In the present study, we demonstrated that JRTs with GI polyps harbor identical germline variant in the APC gene (c.[462_463delinsTT]) in the heterozygous state and thus this disease is an autosomal dominant hereditary disorder. Next, we developed highly reliable genetic tests for hereditary GI polyposis in JRTs, providing accurate assessment of the presence of the causative germline APC variant. The genotyping assays could contribute to the diagnosis and prevention of hereditary GI polyposis in dogs. Furthermore, using the genotyping assays, we showed that the prevalence of the germline APC variant in JRTs in Japan was 1.9% (15/792) and that hereditary GI polyposis would be breed-specific for JRTs.

Academic Significance and Societal Importance of the Research Achievements

ヒトと同様にイヌやネコにも遺伝性疾患が存在するが、遺伝性疾患の原因となる遺伝子異常が明らかになっている疾患は少ない。本研究では、消化管腫瘍を発症したJ.R.テリアには特定の遺伝子変異が認められ、この疾患が遺伝性疾患であることを証明した。疾患の原因となる遺伝子変異を特定したことで、本疾患を疑う症例に出合った場合、獣医師は遺伝子検査による確定診断が可能になる。本研究で開発した遺伝子検査法はすでに実用化されている。また、動物の場合、遺伝子変異を保有する個体を繁殖に用いないようにすれば、疾患の発生を制御することができる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019 2018 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] PCR-based genotyping assays to detect germline APC variant associated with hereditary gastrointestinal polyposis in Jack Russell terriers2021

    • Author(s)
      Yoshizaki Kyoko、Hirata Akihiro、Matsushita Hiroyuki、Nishii Naohito、Kawabe Mifumi、Mori Takashi、Sakai Hiroki
    • Journal Title

      BMC Veterinary Research

      Volume: 17 Issue: 1 Pages: 32-32

    • DOI

      10.1186/s12917-020-02731-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Familial adenomatous polyposis in dogs: hereditary gastrointestinal polyposis in Jack Russell Terriers with germline APC mutations2020

    • Author(s)
      Yoshizaki Kyoko、Hirata Akihiro、Nishii Naohito、Kawabe Mifumi、Goto Minami、Mori Takashi、Sakai Hiroki
    • Journal Title

      Carcinogenesis

      Volume: 42 Issue: 1 Pages: 70-79

    • DOI

      10.1093/carcin/bgaa045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic neuroendocrine carcinoma in a Japanese macaque (Macaca fuscata).2019

    • Author(s)
      Hirata A, Miyamoto Y, Kaneko A, Sakai H, Yoshizaki K, Yanai T, Miyabe-Nishiwaki T, Suzuki J.
    • Journal Title

      J Med Primatol

      Volume: 48 Issue: 2 Pages: 137-140

    • DOI

      10.1111/jmp.12394

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] T-cell/Histiocyte-rich Large B-cell Lymphoma of the Larynx in a Juvenile Japanese Macaque (Macaca fuscata)2019

    • Author(s)
      Hirata A.、Kaneko A.、Sakai H.、Nakamura S.、Yanai T.、Miyabe-Nishiwaki T.、Suzuki J.
    • Journal Title

      Journal of Comparative Pathology

      Volume: 169 Pages: 1-4

    • DOI

      10.1016/j.jcpa.2019.04.004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity in Colorectal Cancer Stem Cells2019

    • Author(s)
      Hirata Akihiro、Hatano Yuichiro、Niwa Masayuki、Hara Akira、Tomita Hiroyuki
    • Journal Title

      Cancer Prevention Research

      Volume: 12 Issue: 7 Pages: 413-420

    • DOI

      10.1158/1940-6207.capr-18-0482

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumour necrosis factor-related apoptosis-inducing ligand induces apoptosis in canine hemangiosarcoma cells in vitro.2019

    • Author(s)
      Goto M, Owaki K, Hirata A, Yanai T, Sakai H.
    • Journal Title

      Veterinary and Comparative Oncolocogy

      Volume: 1 Issue: 3 Pages: 1-13

    • DOI

      10.1111/vco.12471

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Trimer form of tumor necrosis factor-related apoptosis inducing ligand induces apoptosis in canine cell lines derived from mammary tumors2019

    • Author(s)
      GOTO Minami、HIRATA Akihiro、MURAKAMI Mami、SAKAI Hiroki
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 12 Pages: 1791-1803

    • DOI

      10.1292/jvms.19-0469

    • NAID

      130007775511

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a BAC transgenic mouse expressing Krt19-driven iCre recombinase in its digestive organs2019

    • Author(s)
      Kanayama Tomohiro、Tomita Hiroyuki、Binh Nguyen Huy、Hatano Yuichiro、Aoki Hitomi、Okada Hideshi、Hirata Akihiro、Fujihara Yoshitaka、Kunisada Takahiro、Hara Akira
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 8 Pages: e0220818-e0220818

    • DOI

      10.1371/journal.pone.0220818

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lingual ganglioneuroma in a dog2018

    • Author(s)
      Minami Goto, Kayoko Yonemaru, Akkihiro Hirata, Hidenari Furuhashi, Tokuma Yanai T, and Hiroki Sakai
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 3 Pages: 488-491

    • DOI

      10.1292/jvms.17-0602

    • NAID

      130006539123

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brazilian green propolis suppresses acetaminophen-induced hepatocellular necrosis by modulating inflammation-related factors in rats2018

    • Author(s)
      Yuya Tsuchiya, Hiroki Sakai, Akihiro Hirata, and Tokuma Yanai
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 31 Issue: 4 Pages: 275-282

    • DOI

      10.1293/tox.2018-0027

    • NAID

      130007497275

    • ISSN
      0914-9198, 1881-915X
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Gastrointestinal Polyps in Jack Russell Terriers with Germline Mutation of APC Gene2018

    • Author(s)
      Kyoko Yoshizaki, Akihiro Hirata, Naohito Nishii, Mifumi Kawabe, Takashi Mori, Tokuma Yanai and Hiroki Sakai
    • Organizer
      Joint European Society of Veterinary Pathology and European College of Veterinary Pathologists Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] イヌの遺伝性消化管腫瘍の同定2018

    • Author(s)
      平田 暁大、吉嵜 響子、西飯 直仁、川部 美史、森 崇、栁井 徳磨、酒井 洋樹
    • Organizer
      第35回日本毒性病理学会学術集会
    • Related Report
      2018 Research-status Report
  • [Remarks] イヌの新たな遺伝病を発見:ヒトの家族性大腸腺腫症に類似したイヌの遺伝性腫瘍を発見

    • URL

      https://www.gifu-u.ac.jp/news/research/2020/05/entry27-7979.html

    • Related Report
      2020 Annual Research Report 2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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