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The role of IL-19 in the liver immunity

Research Project

Project/Area Number 18K05978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionOsaka Prefecture University

Principal Investigator

AZUMA YASUTAKA  大阪府立大学, 生命環境科学研究科, 教授 (50298816)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsインターロイキン-19 / 肝線維化 / 脂質代謝 / IL-19 / 四塩化炭素 / 肝障害モデル / マクロファージ
Outline of Final Research Achievements

In this research project, the role of IL-19 in non-alcoholic steatohepatitis (NASH) was investigated by analyzing the pathogenesis of fatty liver and liver fibrosis induced by custom-made diets in IL-19 gene-deficient (KO) mice. The pathophysiology of fatty liver in wild-type (WT) mice was analyzed using a custom-made diet, whereas the IL-19KO mice exhibited a fatty liver pathology that progressed to liver fibrosis. Furthermore, mechanistic analysis using an in vitro experimental system revealed that IL-19 suppresses lipid metabolism and shifts it to ATP production. These findings demonstrate that IL-19 plays a role in suppressing fibrosis formation from fatty liver by inhibiting the lipid metabolism system.

Academic Significance and Societal Importance of the Research Achievements

本研究結果により、IL-19は脂質代謝系を抑制して脂肪肝から線維化形成を抑制する役割を担うことを明らかとしたところに学術的意義がある。NASHの病態生理は複雑であり、肝臓内の多くの細胞種が複数のレベルで関与する。今後、基礎研究成果の有効活用のためにも、また治療への応用展開を視野に入れるためにも、病態発症モデルを用いて各種薬物や阻害薬などの効果検証は重要である。その際、探索研究において、ヒトの病態に類似した疾患モデル動物の活用は有用性が高い。IL-19KOに特注飼料を与えることでNASHへと進展する本研究課題の成果は、探索研究に活用できる可能性が大きいところに学術的意義がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2021

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.2021

    • Author(s)
      Azuma YT, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, Aoyama T, Ike M, Ushikai Y, Kuwamura M, Fujii H, Tsuneyama K.
    • Journal Title

      Cells

      Volume: 10 Issue: 12 Pages: 3513-3513

    • DOI

      10.3390/cells10123513

    • NAID

      120007193753

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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