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Elucidation of the transmission and diffusion mechanism of antibacterial resistance in Salmonella that contaminates broilers

Research Project

Project/Area Number 18K05997
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionKagoshima University

Principal Investigator

Chuma Takehisa  鹿児島大学, 農水産獣医学域獣医学系, 教授 (90201631)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsサルモネラ / 抗菌剤耐性 / ブロイラー
Outline of Final Research Achievements

In this study, we isolated Salmonella from the cecal contents of broilers in Kagoshima prefecture, investigated serotype and antimicrobial resistance, and attempted to elucidate the mode of the transmission. From 2018 to 2021, the Salmonella positive rates from individual chickens showed an increasing trend of 12.5, 13.4, 21.6 and 23.6%, respectively, and the positive rates of chicken flock were 72.9%, 72.9%, 89.6% and 93.8%, respectively. As a result of antimicrobial susceptibility testing, ABPC, CTX, and CFX resistance were no longer observed in 2018. On the other hand, from 2018 to 2020, the isolation rate of S. Schwarzengrund increased and KM resistance increased, strongly suggesting a relationship between serotype and resistance acquisition.

Academic Significance and Societal Importance of the Research Achievements

食中毒の原因菌であり近年では薬剤耐性菌の出現も問題視されているサルモネラのブロイラー農場レベルにおける汚染状況が明らかとなった。サルモネラの抗菌剤感受性が近年大きく変化している傾向が認められ、今後の薬剤使用のための有力な情報となった。サルモネラの抗菌剤耐性獲得のメカニズムとして血清型との関わりが示され、抗菌剤耐性菌の蔓延防止につながる可能性がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2022 2021 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (8 results)

  • [Journal Article] Decreasing trend of β-lactam resistance in Salmonella isolates from broiler chickens due to the cessation of ceftiofur in ovo administration2022

    • Author(s)
      Duc V M, Kakiuchi R, Muneyasu H, Toyofuku H, Obi T, Chuma T
    • Journal Title

      Veterinary and Animal Science

      Volume: 16 Pages: 1002481-5

    • DOI

      10.1016/j.vas.2022.100248

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased Salmonella Schwarzengrund prevalence and antimicrobial susceptibility of Salmonella enterica isolated from broiler chickens in Kagoshima Prefecture in Japan between 2013 and 20162020

    • Author(s)
      Duc V M, Shin J, Nagamatsu Y, Fujiwara A, Toyofuku H, Obi T, Chuma T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 82 Pages: 585-589

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence of Salmonella in broiler chickens in Kagoshima, Japan in 2009 to 2012 and the relationship between serovars changing and antimicrobial resistance2019

    • Author(s)
      Duc V. M., Nakamoto Y., Fujiwara A., Toyofuku H., Obi T., and Chuma T.
    • Journal Title

      BMC Veterinary Research

      Volume: 15 Issue: 1 Pages: 108-115

    • DOI

      10.1186/s12917-019-1836-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 2019、2020年に鹿児島県のブロイラーから分離されたサルモネラの抗菌剤耐性2021

    • Author(s)
      守富健人、Phan Thi Thuy Linh、津留優、宗安祥佳、Vu Minh Duc、山元三保子、中馬猛久
    • Organizer
      令和3年度獣医学術九州地区学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The disappearance of β-lactam resistance in Salmonella isolates from broiler chickens in Kagoshima Prefecture in 2018.2020

    • Author(s)
      Vu Minh Duc、宗安祥佳、豊福肇、小尾岳士、中馬猛久
    • Organizer
      第163回日本獣医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Antimicrobial resistance genes of Salmonella serovars isolated from broiler chickens in Kagoshima, Japan2019

    • Author(s)
      Vu Minh Duc、柿内梨那、豊福肇、小尾岳士、中馬猛久
    • Organizer
      第92回日本細菌学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Genetic characterization of beta-lactam resistance in Salmonella isolated from broiler chickens in Kagoshima, Japan2019

    • Author(s)
      Vu Minh Duc、柿内梨那、豊福肇、小尾岳士、中馬猛久
    • Organizer
      第162回日本獣医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] ブロイラー由来サルモネラにおける血清型の流行とβラクタム系抗菌剤耐性の消失2019

    • Author(s)
      宗安祥佳、柿内梨那、Vu Minh Duc、中馬猛久
    • Organizer
      第68回日本獣医公衆衛生学会(九州)
    • Related Report
      2019 Research-status Report
  • [Presentation] ブロイラー盲腸内容物由来サルモネラの陽性率、血清型、薬剤耐性状況の解析2019

    • Author(s)
      ◯柿内梨那、下地康大、Vu Minh Duc、小尾岳士、中馬猛久
    • Organizer
      平成30年度日本獣医師会獣医学術学会年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ブロイラーから分離されたサルモネラの血清型および薬剤耐性の状況2018

    • Author(s)
      ◯柿内梨那、下地康大、Vu Minh Duc、小尾岳士、中馬猛久
    • Organizer
      第67回日本獣医公衆衛生学会(九州)
    • Related Report
      2018 Research-status Report
  • [Presentation] Emergence of Salmonella Schwarzengrund and antimicrobial susceptibility of Salmonella from broiler chicken in Kagoshima, Japan during 2013-20162018

    • Author(s)
      ◯Vu Minh Duc、豊福肇、小尾岳士、中馬猛久
    • Organizer
      第161回日本獣医学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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