Analysis of clinical manifestation diversity of acute Q fever in mouse model
| Project/Area Number |
18K05998
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
ANDOH MASAKO 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10466914)
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| Co-Investigator(Kenkyū-buntansha) |
安藤 秀二 国立感染症研究所, ウイルス第一部, 室長 (30360803)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Q熱 / Coxiella burnetii / コクシエラ / マウスモデル / 感染経路 / 急性Q熱 / マウス病態モデル / 病態解析 / マウス感染モデル / 肺炎 / 肝炎 / 病原性 |
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| Outline of Final Research Achievements |
Q fever is a worldwide zoonoses. Acute Q fever symptoms reported in abroad are mainly pneumonia and hepatitis, while in Japan it is fatigue syndrome. Factors for variation of the symptoms are still unclear.
In this study, mouse challenged Coxiella burnetii intratracheally demonstrated apparent clinical signs and different outcome depends on genotype of C. burnetii. Oral challenge resulted unsuccessful infection. Variation of Q fever symptom may be affected by route of infection, amount of exposure, and C. burnetii genotype. These results highlight difficulty of clinical diagnoses of Q fever. Promotion of appropriate laboratory diagnoses is needed for safer management of zoonoses in Japan.
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| Academic Significance and Societal Importance of the Research Achievements |
Q熱は、厚生労働省と農林水産省が管轄する法令で指定されている重要な人獣共通感染症である。世界各地に分布する菌の遺伝子型が異なり、それが臨床症状に関与していると考えられているが証明されていなかった。特に日本では「不明熱」として確定診断されずに見過ごされている。本研究によりQ熱の病態の多様性には様々な要因が関与しており、臨床症状からの診断は極めて困難であることが裏付けられた。人獣共通感染症の安全対策として、実験室内診断の普及啓発が必要である。希少感染症は、研究者の有無で国単位の対策に大きな差が出ることから、今後も継続してQ熱の研究に取り組みたい。
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Report
(5 results)
Research Products
(4 results)
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[Journal Article] Molecular prevalence of Anaplasma marginale and Ehrlichia in domestic large ruminants and Rhipicephalus (Boophilus) microplus ticks from southern Luzon, Philippines.2021
Author(s)
Remil Galay, Carina R Llaneta, Maria Karla Faye Monreal, Antero Armero, Arinanne Bel Baluyut, Czarina Marie Regino, Kristina Andrea Sandalo, Billy Vidina, Melbourne Talactac, Lennox Tapawan, Maarten Czar Mojares, Cherry Alvarez, Emmanuel Mago, Noemi Encarnacion, Masako Andoh, Tetsuya Tanaka
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Journal Title
Frontiers in Veterinary Science
Volume: 8
Pages: 746705-746705
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Molecular detection of Rickettsia spp. and Coxiella burnetii in cattle, water buffaloes, and Rhipicephalus (Boophilus) microplus ticks in Luzon Island of the Philippines2020
Author(s)
Remil Galay, Melbourne Talactac, Bea Ambita, Dawn Chu, Lali dela Costa, Cinnamon Salangsang, Darwin Caracas, Florante Generoso, Jonathan Babelonia, Joeneil Vergano, Lena Berana, Kristina Sandalo, Billy Divina, Cherry Alvarez, Emman Mago, Masako Andoh, Tetsuya Tanaka
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Journal Title
Trop. Med. Infect. Dis.
Volume: 5(2)
Issue: 2
Pages: 54-54
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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