Analysis of maternal Ovo protein during germ cell formation in Drosophila
Project/Area Number |
18K06308
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 44040:Morphology and anatomical structure-related
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Research Institution | University of Tsukuba |
Principal Investigator |
Hayashi Makoto 筑波大学, 生存ダイナミクス研究センター, 助教 (50714838)
|
Project Period (FY) |
2018-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | ショウジョウバエ / 始原生殖細胞 / 母性Ovoタンパク質 / 配偶子形成 / 生殖系列 / 転写制御因子 / 母性Ovo / 生殖細胞 / 母性因子 / Ovo |
Outline of Final Research Achievements |
Maternal Ovo protein have been shown to regulating germ-cell specific gene expression in Drosophila. However, the role of maternal Ovo protein during germ cell differentiation remains unclear, since the maternal Ovo protein knockdown induces germline loss phenotype during larval stage in both sexes. Therefore, in this study, we identified and analyzed the genes whose transcription is activated by maternal Ovo protein.
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Academic Significance and Societal Importance of the Research Achievements |
本研究で着目したovo遺伝子は、ショウジョウバエだけでなく、系統的に遠い関係にあるマウスにおいてもそのオルソログ(ovol2遺伝子)が生殖細胞の形成に必要であることが明らかになっている。よって、本研究で明らかになった知見は、ショウジョウバエだけでなく、マウスを含む多くの動物種において共通した生殖細胞形成機構を見出せる可能性を有している。
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Report
(5 results)
Research Products
(11 results)
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[Presentation] Identification of the molecular markers preferentially expressed in spermatogonial stem cells in fish2019
Author(s)
Hayashi, M., Iwasaki, Y., Hayashi, T., Ebisawa, M., Sasagawa, Y., Yoshimura, M., Ichida, K., Nikaido, I., Yoshizaki, G.
Organizer
Marine Biotechnology Conference 2019
Related Report
Int'l Joint Research
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