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Analysis of maternal Ovo protein during germ cell formation in Drosophila

Research Project

Project/Area Number 18K06308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44040:Morphology and anatomical structure-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Hayashi Makoto  筑波大学, 生存ダイナミクス研究センター, 助教 (50714838)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsショウジョウバエ / 始原生殖細胞 / 母性Ovoタンパク質 / 配偶子形成 / 生殖系列 / 転写制御因子 / 母性Ovo / 生殖細胞 / 母性因子 / Ovo
Outline of Final Research Achievements

Maternal Ovo protein have been shown to regulating germ-cell specific gene expression in Drosophila. However, the role of maternal Ovo protein during germ cell differentiation remains unclear, since the maternal Ovo protein knockdown induces germline loss phenotype during larval stage in both sexes. Therefore, in this study, we identified and analyzed the genes whose transcription is activated by maternal Ovo protein.

Academic Significance and Societal Importance of the Research Achievements

本研究で着目したovo遺伝子は、ショウジョウバエだけでなく、系統的に遠い関係にあるマウスにおいてもそのオルソログ(ovol2遺伝子)が生殖細胞の形成に必要であることが明らかになっている。よって、本研究で明らかになった知見は、ショウジョウバエだけでなく、マウスを含む多くの動物種において共通した生殖細胞形成機構を見出せる可能性を有している。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Repression of G1/S Transition by Transient Inhibition of miR-10404 Expression in Drosophila Primordial Germ Cells2020

    • Author(s)
      Morita Shumpei、Ota Ryoma、Hayashi Makoto、Kobayashi Satoru
    • Journal Title

      iScience

      Volume: 23 Issue: 3 Pages: 100950-100950

    • DOI

      10.1016/j.isci.2020.100950

    • NAID

      120007163353

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A truncated form of a transcription factor Mamo activates vasa in Drosophila embryos2019

    • Author(s)
      Nakamura Shoichi、Hira Seiji、Fujiwara Masato、Miyagata Nasa、Tsuji Takuma、Kondo Akane、Kimura Hiroshi、Shinozuka Yuko、Hayashi Makoto、Kobayashi Satoru、Mukai Masanori
    • Journal Title

      Communications Biology

      Volume: 2:422 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-019-0663-4

    • NAID

      120007127685

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of novel monoclonal antibodies for identification of type A spermatogonia in teleosts†2019

    • Author(s)
      Hayashi Makoto、Ichida Kensuke、Sadaie Sakiko、Miwa Misako、Fujihara Ryo、Nagasaka Yasuhiko、Yoshizaki Goro
    • Journal Title

      Biology of Reproduction

      Volume: 101 Issue: 2 Pages: 478-491

    • DOI

      10.1093/biolre/ioz080

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] ショウジョウバエ生殖細胞形成過程における母性Ovoタンパク質下流遺伝子の解析2020

    • Author(s)
      古賀結花, 林誠, 小林悟
    • Organizer
      第91回日本動物学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 海野太一, 藤原亮, 水谷波南香, 吉崎悟朗, 小林悟, 林誠2020

    • Author(s)
      宿主生殖腺への高い生着能を有する精原細胞濃縮法の開発
    • Organizer
      令和2年度日本水産学会春季大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Identification of the molecular markers preferentially expressed in spermatogonial stem cells in fish2019

    • Author(s)
      Hayashi, M., Iwasaki, Y., Hayashi, T., Ebisawa, M., Sasagawa, Y., Yoshimura, M., Ichida, K., Nikaido, I., Yoshizaki, G.
    • Organizer
      Marine Biotechnology Conference 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエ始原生殖細胞における体細胞性遺伝子抑制機構の役割2019

    • Author(s)
      香山瑞生, 浅岡美穂, 森田俊平, 林誠, 小林悟
    • Organizer
      第90回日本動物学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ショウジョウバエ始原生殖細胞の性決定に関与する新規遺伝子の探索2019

    • Author(s)
      三浦博樹, 太田龍馬, 林誠, 小林悟
    • Organizer
      第90回日本動物学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ショウジョウバエ始原生殖細胞における遺伝子量補償の欠如による生食系列の性決定機構2018

    • Author(s)
      太田龍馬, 林誠, 森田俊平, 小林悟
    • Organizer
      第89回日本動物学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ショウジョウバエ始原生殖細胞の性決定に関与する新規遺伝子の探索2018

    • Author(s)
      三浦博樹, 太田龍馬, 林誠, 小林悟
    • Organizer
      第89回日本動物学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ショウジョウバエ始原生殖細胞における体細胞性遺伝子抑制機構の役割2018

    • Author(s)
      香山瑞生, 浅岡美穂, 森田俊平, 林誠, 小林悟
    • Organizer
      第89回日本動物学会大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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