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The brain circuit mechanism for controlling the serotonin to promote the waiting behavior for future rewards : The verification by combination of calcium imaging and optogenetics.

Research Project

Project/Area Number 18K06346
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

Miyazaki Kayoko  沖縄科学技術大学院大学, 神経計算ユニット, グループリーダー (80426577)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywordsセロトニン / 辛抱強さ / 報酬 / カルシウムイメージング / 報酬待機行動 / 光操作 / Ca画像化
Outline of Final Research Achievements

We have succeeded in recording the serotonin neural activity in the dorsal raphe nucleus (DRN) by calcium imaging with Inscopix nVista. Now we are in the stage of recording the neural activity during the several behavioral tasks. In parallel with this experiment, we have started the recording of the population of serotonin neural activity in DRN using a fiber photometry system. In that experiment, it was confirmed that the firing frequency increased while waiting for rewards and when acquiring the rewards. We plan to continue both experiments in the future.

Academic Significance and Societal Importance of the Research Achievements

私達は常に変化する環境に適応しながら報酬を獲得し罰を回避することでその生存を維持していますが、将来的な報酬を待つ場合、その報酬の内的な価値や確率によって獲得行動に至る意思決定は様々に変化します。このプロセスにセロトニンが重要であることを私達はこれまでに突き止めており、本研究ではこの詳細な脳内メカニズムを明らかにします。この研究は意思決定を担う脳基盤におけるセロトニンの動的な役割を照らし出すもので、将来的にうつなどセロトニンが関わる精神疾患を生じさせる神経基盤の解明に寄与できると考えています。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (7 results)

All 2021 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Serotonergic Modulation of Cognitive Computations2021

    • Author(s)
      Kenji Doya, Kayoko W. Miyazaki, Katsuhiko Miyazaki
    • Journal Title

      Current opinion of Behavioral Sciences

      Volume: Volume 38, April 2021 Pages: 116-123

    • DOI

      10.1016/j.cobeha.2021.02.003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards2020

    • Author(s)
      Miyazaki K, Miyazaki KW, Sivori G, Yamanaka A, Tanaka KF, Doya K
    • Journal Title

      Science Advances

      Volume: 6 Issue: 48 Pages: 7246-7246

    • DOI

      10.1126/sciadv.abc7246

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience2018

    • Author(s)
      Miyazaki K*, Miyazaki KW*, Yamanaka A, Tokuda T, Tanaka KF, Doya K *These authors contributed equally to this work.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2048-2048

    • DOI

      10.1038/s41467-018-04496-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The orbitofrontal and medial prefrontal cortices differentially calculate the posterior probability of reward delivery to modulate waiting for future rewards2020

    • Author(s)
      Miyazaki K, Miyazaki KW, Doya, K
    • Organizer
      12th Forum of European Neuroscience
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stimulation of serotonergic terminals in the orbitofrontal and medial prefrontal cortices differentially affects waiting for the future rewards.2019

    • Author(s)
      Miyazaki KW, Miyazaki K, Yamanaka A, Tanaka KF, Doya K
    • Organizer
      Society for Neuroscience
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] セロトニンによる報酬待機行動の制御機構2019

    • Author(s)
      宮崎勝彦 宮崎佳代子 銅谷賢治
    • Organizer
      254th Tsukuba Brain Science Seminar
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Serotonergic effect on motor actions for future rewards in mice.2018

    • Author(s)
      Taira M, Miyazaki KW, Miyazaki K, Doya K
    • Organizer
      11th Forum of European Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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