Quality control of the transltion system in the organella
| Project/Area Number |
18K06350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 45010:Genetics-related
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| Research Institution | Okayama University |
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Principal Investigator |
ABO Tatsuhiko 岡山大学, 自然科学学域, 教授 (90303601)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リボソームレスキュー / 翻訳 / オルガネラ / 葉緑体 / ArfB / バクテリア / リボソーム |
|---|
| Outline of Final Research Achievements |
The homologs of Escherichia coli ribosome rescue factor ArfB were found in Arabidopsis thaliana and Marchantia polymorpha L. and named AtArfB and MpARFB, respectively. Both showed ribosome rescue activity in E. coli translation system and localized in chloroplast. Lack of AtArfB resulted in subtle reduction of the leaf size. Preliminary results suggested MpARFB is required for genital development.
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| Academic Significance and Societal Importance of the Research Achievements |
リボソームレスキューが健全な翻訳系維持に必須であることが最近示されている。オルガネラ，すなわち葉緑体やミトコンドリアの翻訳系は原核細胞の翻訳系に類似しており，そこに大腸菌のリボソームレスキュー因子ArfBのホモログが見出されたことは，リボソームレスキューが生物種を超えて重要な役割を果たすことを示唆する。さらに，本研究は，光合成の場である葉緑体の健全性の維持機構の解明を通して，CO2削減，持続的成長の維持に重要な役割を果たすものと期待できる。
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Report
(6 results)
Research Products
(9 results)
