• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of Hippo pathway transcriptional co-activator, YAP1 in the pathogenesis of Atherosclerosis

Research Project

Project/Area Number 18K06703
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47040:Pharmacology-related
Research InstitutionHokkaido University of Science

Principal Investigator

TAKAGURI AKIRA  北海道科学大学, 薬学部, 准教授 (90623710)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords動脈硬化 / 血管平滑筋細胞 / YAP1 / 炎症 / 内膜肥厚 / 腹部大動脈瘤 / 血管平滑筋細胞特異的YAP1ノックアウトマウス / Hippo経路 / 血管平滑筋特異的ノックアウトマウス / プラーク破綻
Outline of Final Research Achievements

Yes-associated protein (YAP)1 is regulated by Hippo pathway, which controls cell survival and cell death in vascular smooth muscle cells. In this study, we investigated the role of YAP1 on the progression of atherosclerosis using a smooth muscle specific YAP1-KO mouse. Smooth muscle specific YAP1-KO mice showed decreased neointima formation induced by injury in carotid artery. Also, activation of YAP1 causes cell proliferation mediated by the phosphorylation of Akt in vascular smooth muscle cells. Accordingly, it suggests that YAP1 is a critical molecules for the pathogenesis of atherosclerosis.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、血管平滑筋細胞のYAP1が、内膜の障害により生じる内膜肥厚形成に重要な働きをすること、その機序としてAktの活性化に影響を与えることを明らかにした。本研究の成果は、YAP1が動脈硬化の形成・進展に重要な役割をもつことを示唆するものであり、これら疾患に対する新たな治療戦略を提唱に繋がる所見と考えられる。また、将来的には、YAP1の活性化と関連する疾患、がん、関節リウマチなどの疾患への応用展開に繋がることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells2021

    • Author(s)
      Chiba T., Takaguri A., Maeda T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 545 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2021.01.015

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of circadian clock gene BMAL1 in vascular proliferation2020

    • Author(s)
      Takaguri Akira、Sasano Jun、Akihiro Oomiya、Satoh Kumi
    • Journal Title

      European Journal of Pharmacology

      Volume: 872 Pages: 172924-172924

    • DOI

      10.1016/j.ejphar.2020.172924

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of Yes‐associated protein 1 (YAP1) in doxorubicin‐induced cytotoxicity in H9c2 cardiac cells2020

    • Author(s)
      Takaguri Akira、Akihiro Ohmiya、Sasano Jun、Satoh Kumi
    • Journal Title

      Cell Biology International

      Volume: 44 Issue: 3 Pages: 873-881

    • DOI

      10.1002/cbin.11285

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metabolomic analysis of SMP30/GNL knockout mice treated with fermented vegetable and fruit extract (OM-X?)2020

    • Author(s)
      Wakame Koji、Takahata Muneaki、Miyake Yasuyoshi、Yasuda Eri、Shimomiya Yoshie、Nakata Akifumi、Sato Keisuke、Mihara Yoshihiro、Takaguri Akira、Komatsu Ken-ichi
    • Journal Title

      Functional Foods in Health and Disease

      Volume: 10 Issue: 3 Pages: 95-95

    • DOI

      10.31989/ffhd.v10i3.674

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elucidation of a New Mechanism of Onset of Insulin Resistance: Effects of Statins and Tumor Necrosis Factor-α on Insulin Signal Transduction2018

    • Author(s)
      Takaguri Akira
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 138 Issue: 11 Pages: 1329-1334

    • DOI

      10.1248/yakushi.18-00116

    • NAID

      130007503045

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2018-11-01
    • Related Report
      2018 Research-status Report
  • [Journal Article] Global Liver Gene Expression Analysis on a Murine Hepatic Steatosis Model Treated with Mulberry (Morus alba L.) Leaf Powder2018

    • Author(s)
      UCHIYAMA HIRONOBU、KOMATSU KEN-ICHI、NAKATA AKIFUMI、SATO KEISUKE、MIHARA YOSHIHIRO、TAKAGURI AKIRA、NAGASHIMA TAKAYUKI、WAKAME KOJI
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 7 Pages: 4305-4311

    • DOI

      10.21873/anticanres.12729

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] ドキソルビシンに誘発される血管炎症における 時計遺伝子BMAL1の役割2021

    • Author(s)
      髙栗郷、森脇槙菜、佐藤久美
    • Organizer
      日本薬学会北海道支部第148回例会(札幌)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 血管平滑筋細胞の増殖における時計遺伝子BMAL1の役割解明2019

    • Author(s)
      高栗郷、笹野潤、近江谷允明、佐藤久美
    • Organizer
      第70回日本薬理学会北部会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血管リモデリングにおける時計遺伝子Bmalの役割解明2019

    • Author(s)
      高栗郷、笹野潤、近江谷允明、久保貴司、佐藤久美
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 時計遺伝子Bmal1の内膜肥厚形成制御に関する検討2018

    • Author(s)
      久保貴司、高栗郷、佐藤久美
    • Organizer
      日本薬学会北海道支部第145回例会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血管平滑筋細胞における細胞増殖と細胞死に及ぼすYAP1の機能的役割2018

    • Author(s)
      久保貴司、高栗郷、佐藤久美
    • Organizer
      第91回日本薬理学会年会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi