The role of taste receptors in immunology
Project/Area Number |
18K06713
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47040:Pharmacology-related
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
SAEKI Mayumi 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 (00462771)
|
Project Period (FY) |
2018-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 免疫 / T細胞 / 味覚受容体 / アレルギー / 味覚 / 免疫応答 / 苦味受容体 |
Outline of Final Research Achievements |
Our previous study has reported that the involvement of taste receptors in the efficacy of sublingual immunotherapy. In the present study, we investigated that the role of taste receptor in T cells. Cytokine expression by T cell activation signal was suppressed in taste receptor‐expressing cells, compared to wild type cells. Taste receptor and their ligands may inhibit the activation of T cells.
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Academic Significance and Societal Importance of the Research Achievements |
以前の臨床研究において、我々は、舌下免疫療法の奏功に苦味受容体が関与する可能性を報告したが、本研究で、はじめて、苦味受容体が実際T細胞の活性化に影響を与えることを示した。今後、更に研究を進めることにより、舌下免疫療法の奏功機序の解明につながることが期待される。
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Report
(5 results)
Research Products
(8 results)