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The role of taste receptors in immunology

Research Project

Project/Area Number 18K06713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47040:Pharmacology-related
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

SAEKI Mayumi  公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主席研究員 (00462771)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords免疫 / T細胞 / 味覚受容体 / アレルギー / 味覚 / 免疫応答 / 苦味受容体
Outline of Final Research Achievements

Our previous study has reported that the involvement of taste receptors in the efficacy of sublingual immunotherapy. In the present study, we investigated that the role of taste receptor in T cells. Cytokine expression by T cell activation signal was suppressed in taste receptor‐expressing cells, compared to wild type cells. Taste receptor and their ligands may inhibit the activation of T cells.

Academic Significance and Societal Importance of the Research Achievements

以前の臨床研究において、我々は、舌下免疫療法の奏功に苦味受容体が関与する可能性を報告したが、本研究で、はじめて、苦味受容体が実際T細胞の活性化に影響を与えることを示した。今後、更に研究を進めることにより、舌下免疫療法の奏功機序の解明につながることが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2021 2020 2019 2018 Other

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) Remarks (3 results)

  • [Journal Article] Association of Basophil-Expressing Genes with Effectiveness of Sublingual Immunotherapy2020

    • Author(s)
      Gotoh Minoru、Kaminuma Osamu、Nakaya Akihiro、Saeki Mayumi、Nishimura Tomoe、Kitamura Noriko、Hiroi Takachika、Okubo Kimihiro
    • Journal Title

      Journal of Nippon Medical School

      Volume: 87 Issue: 1 Pages: 49-52

    • DOI

      10.1272/jnms.JNMS.2020_87-104

    • NAID

      130007807559

    • ISSN
      1345-4676, 1347-3409
    • Year and Date
      2020-02-15
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Potential mechanisms of T cell-mediated and eosinophil-independent bronchial hyperresponsiveness.2019

    • Author(s)
      Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T.
    • Journal Title

      Int J Mol Sci.

      Volume: 20 Issue: 12 Pages: 2980-2981

    • DOI

      10.3390/ijms20122980

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] スギ花粉症舌下免疫療法の効果発現機序の探索2021

    • Author(s)
      佐伯 真弓、北村 紀子、神沼 修、廣井 隆親、湯田 厚司、後藤 穣
    • Organizer
      第70回 日本アレルギー学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アレルゲン免疫療法の効果発現に関わる好塩基球およびマスト細胞関連メディエーター.2019

    • Author(s)
      神沼 修,後藤 穣,中谷明弘,北村紀子,西村友枝,佐伯真弓, 廣井隆親,森 晶夫,大久保公裕.
    • Organizer
      アレルギー・好酸球研究会2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 舌下免疫療法における味覚受容体を介した奏功メカニズム2018

    • Author(s)
      佐伯 真弓,後藤 穣,大久保 公裕,中谷 明弘,北村 紀子,西村 友枝,神沼 修,廣井 隆親
    • Organizer
      第1回日本アレルギー学会関東地方会
    • Related Report
      2018 Research-status Report
  • [Remarks] 公益財団法人 東京都医学総合研究所 花粉症研究室ホームページ

    • URL

      https://www.igakuken.or.jp/allergy/

    • Related Report
      2020 Research-status Report
  • [Remarks] http://www.igakuken.or.jp/allergy/

    • Related Report
      2019 Research-status Report
  • [Remarks] 公益財団法人 東京都医学総合研究所 花粉症プロジェクトホームページ

    • URL

      http://www.igakuken.or.jp/allergy/

    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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