Search for functional ingredients to improve glucose and/or lipid metabolism from edible resources
| Project/Area Number |
18K06726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Kindai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
二宮 清文 就実大学, 薬学部, 教授 (10434862)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖代謝改善効果 / 脂質代謝改善効果 / 食用資源 / 機能性成分 / サラシア / カンカニクジュヨウ / Salacia chinensis / salacinol / neokotalanol / α-グルコシダーゼ阻害活性 / ローズヒップ / trans-tiliroside / 体脂肪低減作用 / 糖および脂質代謝改善効果 / 胡黄連 / Mammea siamensis / salacinol高活性アナログ / echinacoside / acteoside / helichrysoside / Melodorum fruticosum / Carapa guianensis / 糖・脂質代謝改善効果 / 医薬シーズ探索 |
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| Outline of Final Research Achievements |
To explore new functional ingredients for improve glucose and/or lipid metabolisms from natural resources used for medicinal purposdes in traditional and folk medicines as well as also used as edible resources. Thus, we searched for new bioactive constituents for preventing diabetes or dyslipidemia based on visceral fat accumulation and alleviating their early symptoms. In addition, we aim to bioactivity evaluate of the active constituents and propose and develop new functional food and phytopharmaceutical candidate ingredients based on the evidence. Furthermore, we also aim to create new candidates by synthesizing and evaluating the total synthesis and analogues of the active components as new seeds.
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| Academic Significance and Societal Importance of the Research Achievements |
セルフメディケーションやセルフプリベンションの推進による医療費高騰の抑止は，我が国において最も憂慮すべき喫緊課題のひとつに挙げられる．本研究の学術的意義はその課題解決策の一助になりうることであり，糖尿病あるいは脂質異常症の予防およびそれらの初期症状の緩和に効果のある食用資源を，糖および脂質代謝改善効果を指標に探索し，その活性寄与成分を明らかにするなどのエビデンスに基づいた科学的評価を実践する．その波及効果として，見いだされた高付加価値を有する食用資源を活用した６次産業化による生産地域の産業振興が見込めることから，その社会的意義も高いものと考える．
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Report
(5 results)
Research Products
(187 results)
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[Presentation] Neokotalanol, a principal thiosugar sulfonium constituent in the stems of Salacia chinensis improves HbA1c levels in genetically obese-hyperglycemic ob/ob mice2019
Author(s)
Toshio Morikawa, Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka
Organizer
20th Tetrahedron Symposium (Bangkok, Thailand)
Related Report
Int'l Joint Research
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[Presentation] Limonoids from andiroba (Carapa guianensis) improve glucose and lipid metabolism in hepatocytes2019
Author(s)
Toshio Morikawa, Akifumi Nagatomo, Shinsuke Marumoto, Chie Sakai, Osamu Muraoka, Takashi Kikuchi, Takeshi Yamada, Reiko Tanaka, Kiyofumi Ninomiya
Organizer
27th International Society of Heterocyclic Chemistry Congress (27thISHC, Kyoto, Japan)
Related Report
Int'l Joint Research
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[Presentation] Neokotalanol, a principal thiosugar sulfonium constituent in Salacia chinensis, suppresses HbA1c levels in genetically obese-hyperglycemic ob/ob mice2019
Author(s)
Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka, Toshio Morikawa
Organizer
27th International Society of Heterocyclic Chemistry Congress (27thISHC, Kyoto, Japan)
Related Report
Int'l Joint Research
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[Presentation] Salacia chinensis stem extract and its thiosugar sulfonium constituent, neokotalanol, improves HbA1c levels in ob/ob mice2019
Author(s)
Toshio Morikawa, Masakazu Kobayashi, Junji Akaki, Yasuyo Yamaguchi, Hiroo Yamasaki, Kiyofumi Ninomiya, Yutana Pongpiriyadacha, Masayuki Yoshikawa, Osamu Muraoka
Organizer
The 7th International Conference on Food Factors (ICoFF2019)/The 12th International Conference and Exhibition on Nutraceuticals and Functional Foods (ISNFF2019), (Koby, Japan)
Related Report
Int'l Joint Research
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[Presentation] Anti-obese effect of trans-tiliroside2018
Author(s)
Ninomiya Kiyofumi, Kitahara Megumi, Hori Yuichiro, Sakai Chie, Nagatomo Akifumi, Yoshikawa Masayuki, Muraoka Osamu, Morikawa Toshio
Organizer
29th International Conference on Polyphenols / 9 th Tannin Conference (ICP+TC 2018, Madison, USA)
Related Report
Int'l Joint Research
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[Presentation] Highly diastereoselective synthesis of salacinol-type α-glucosidase inhibitors and evaluation of their in vivo α-glucosidase inhibitory activity2018
Author(s)
Ishikawa Fumihiro, Jinno Kazumi, Sonoda Naoki, Kinouchi Eri, Akaki Junji, Ninomiya Kiyofumi, Marumoto Shinsuke, Muraoka Osamu, Morikawa Toshio, Tanabe Genzoh
Organizer
28th International Symposium on the Organic Chemistry of Sulfur (ISOCS-28, Tokyo, Japan)
Related Report
Int'l Joint Research
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