Development of a treatment for post-cardiopulmonary resuscitation encephalopathy utilizing existing approved drugs using large-scale medical claims database

• Project/Area Number: 18K06785
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Okayama University (2021); The University of Tokushima (2018-2020)
• Principal Investigator: Zamami Yoshito 岡山大学, 大学病院, 教授 (70550250)
• Co-Investigator(Kenkyū-buntansha): 今西 正樹 徳島大学, 大学院医歯薬学研究部(薬学域), 助教 (00734344) ; 武智 研志 徳島大学, 病院, 特任助教 (90793240) ; 中馬 真幸 徳島大学, 病院, 特任助教 (20819289) ; 合田 光寛 徳島大学, 病院, 特任助教 (40585965)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ドラッグリポジショニング / 心肺蘇生 / 蘇生後脳症 / 医療情報データベース / 心肺停止 / データべース / 医療ビッグデータ / 既存承認薬 / 心肺蘇生後脳症

Outline of Final Research Achievements

We searched data collected from the Japan Medical Data Center for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using "TargetMine," a drug discovery tool. Then, we investigated whether the candidate drugs were administered to the 2,227 cardiac arrest patients included in this study. The results of the logistic regression analysis showed that three drugs (isosorbide dinitrate, nitroglycerin, and nicardipine) that were showed significant association with improvement in the proportion of survival discharge. Thus, it can be suggested that isosorbide dinitrate, nitroglycerin, and nicardipine could be novel therapeutic agents for improving the prognosis of cardiac arrest patients.

Academic Significance and Societal Importance of the Research Achievements

現在、心肺停止後の予後を改善する適切な治療薬はなく、蘇生後脳症などを併発することからも治療は長期にわたる。くわえて、後遺症が続く場合は介護が必要となり経済的負担が発生する。そのため、新規治療薬物の開発が望まれていた。本研究手法のドラッグリポジショニングは、既存薬を用いることから、心肺停止後の予後の改善に対して、適切かつ早期に治療法を提案することが可能となる。これにより、心肺停止後の治療に対する寄与および医療経済負担を軽減することが期待される。

Research Products

• [Journal Article] Identification of prophylactic drugs for oxaliplatin-induced peripheral neuropathy using big data. (2022)
  • Author(s): Zamami Y, Niimura T, Kawashiri T, Goda M, Naito Y, Fukushima K, Ushio S, Aizawa F, Hamano H, Okada N, Yagi K, Miyata K, Takechi K, Chuma M, Koyama T, Kobayashi D, Shimazoe T, Fujino H, Izawa-Ishizawa Y, Ishizawa K.
  • Journal Title: Biomed Pharmacother. Volume: 148 Pages: 112744-112744
  • DOI: 10.1016/j.biopha.2022.112744
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Palonosetron on Nausea and Vomiting Induced by Multiple-Day Chemotherapy: A Retrospective Study (2021)
  • Author(s): Hamano H, Mitsuhashi C, Suzuki Y, Zamami Y, Tsujinaka K, Okada N, Niimura T, Hayama T, Imai T, Ishida S, Sakamoto K, Goda M, Takechi K, Yagi K, Chuma M, Horinouchi Y, Shinomiya K, Ikeda Y, Kirino Y, Nakamura T, Yanagawa H, Hamada Y, Ishizawa K.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 44 Issue: 4 Pages: 478-484
  • DOI: 10.1248/bpb.b20-00609
  • NAID: 130008014271
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2021-04-01
  • Peer Reviewed / Open Access
• [Journal Article] Drug-Repositioning Approaches Based on Medical and Life Science Databases. (2021)
  • Author(s): Zamami Y, Hamano H, Niimura T, Aizawa F, Yagi K, Goda M, Izawa-Ishizawa Y, Ishizawa K.
  • Journal Title: Front Pharmacol. Volume: 12 Pages: 752174-752174
  • DOI: 10.3389/fphar.2021.752174
  • Peer Reviewed / Open Access
• [Journal Article] Advanced Life Support vs. Basic Life Support for Patients With Trauma in Prehospital Settings: A Systematic Review and Meta-Analysis (2021)
  • Author(s): Kondo Yutaka、Fukuda Tatsuma、Uchimido Ryo、Kashiura Masahiro、Kato Soichiro、Sekiguchi Hiroshi、Zamami Yoshito、Hifumi Toru、Hayashida Kei
  • Journal Title: Frontiers in Medicine Volume: 8
  • DOI: 10.3389/fmed.2021.660367
  • NAID: 120007168808
  • Peer Reviewed / Open Access
• [Journal Article] Trends in hepatitis C virus‐associated mortality rates in Japan, 1998-2017 (2021)
  • Author(s): Hagiya Hideharu、Koyama Toshihiro、Deguchi Matsuo、Minato Yusuke、Miura Satomi、Funahashi Tomoko、Teratani Yusuke、Zamami Yoshito、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: - Issue: 9 Pages: 2486-2492
  • DOI: 10.1111/jgh.15517
  • Peer Reviewed
• [Journal Article] Population-Based Observational Study of Adverse Drug Event-Related Mortality in the Super-Aged Society of Japan (2021)
  • Author(s): Funahashi Tomoko、Koyama Toshihiro、Hagiya Hideharu、Harada Ko、Iinuma Syunya、Ushio Soichiro、Zamami Yoshito、Niimura Takahiro、Shinomiya Kazuaki、Ishizawa Keisuke、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
  • Journal Title: Drug Safety Volume: - Issue: 5 Pages: 531-539
  • DOI: 10.1007/s40264-020-01037-9
  • Peer Reviewed
• [Journal Article] The Risk Factors Associated with Immune Checkpoint Inhibitor-Related Pneumonitis (2021)
  • Author(s): Asada Mizuho、Mikami Takahisa、Niimura Takahiro、Zamami Yoshito、Uesawa Yoshihiro、Chuma Masayuki、Ishizawa Keisuke
  • Journal Title: Oncology Volume: 99 Issue: 4 Pages: 256-259
  • DOI: 10.1159/000512633
  • Peer Reviewed
• [Journal Article] Neuroimmunological adverse events associated with immune checkpoint inhibitor: a retrospective, pharmacovigilance study using FAERS database (2021)
  • Author(s): Mikami Takahisa、Liaw Bobby、Asada Mizuho、Niimura Takahiro、Zamami Yoshito、Green-LaRoche Deborah、Pai Lori、Levy Michael、Jeyapalan Suriya
  • Journal Title: Journal of Neuro-Oncology Volume: 152 Issue: 1 Pages: 135-144
  • DOI: 10.1007/s11060-020-03687-2
• [Journal Article] Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity (2021)
  • Author(s): Hamano H, Ikeda Y, Goda M, Fukushima K, Kishi S, Chuma M, Yamashita M, Niimura T, Takechi K, Imanishi M, Zamami Y, Horinouchi Y, Izawa-Ishizawa Y, Miyamoto L, Ishizawa K, Fujino H, Tamaki T, Aihara KI,
  • Journal Title: Kidney International Volume: 99 Issue: 4 Pages: 885-899
  • DOI: 10.1016/j.kint.2020.10.041
  • NAID: 120007175668
  • Peer Reviewed / Open Access
• [Journal Article] Differences in risk factors for anticoagulant‐related nephropathy between warfarin and direct oral anticoagulants: Analysis of the Japanese adverse drug event report database (2020)
  • Author(s): Mitsuboshi Satoru、Niimura Takahiro、Zamami Yoshito、Ishizawa Keisuke
  • Journal Title: British Journal of Clinical Pharmacology Volume: - Issue: 7 Pages: 2977-2981
  • DOI: 10.1111/bcp.14688
  • Peer Reviewed
• [Journal Article] Investigation of drugs affecting hypertension in bevacizumab‐treated patients and examination of the impact on the therapeutic effect (2020)
  • Author(s): Yagi Kenta、Mitstui Marin、Zamami Yoshito、Niimura Takahiro、Izawa‐Ishizawa Yuki、Goda Mitsuhiro、Chuma Masayuki、Fukunaga Kimiko、Shibata Takahiro、Ishida Shunsuke、Sakurada Takumi、Okada Naoto、Hamano Hirofumi、Horinouchi Yuya、Ikeda Yasumasa、Yanagawa Hiroaki、Ishizawa Keisuke
  • Journal Title: Cancer Medicine Volume: 10 Issue: 1 Pages: 164-172
  • DOI: 10.1002/cam4.3587
  • NAID: 120007147667
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant Use of Acetaminophen and Aspirin Increases Risk of Kidney Injury: Analysis of the Japanese Adverse Drug Event Report Database (2020)
  • Author(s): Mitsuboshi Satoru、Niimura Takahiro、Zamami Yoshito
  • Journal Title: The Journal of Clinical Pharmacology Volume: 61 Issue: 2 Pages: 269-270
  • DOI: 10.1002/jcph.1756
• [Journal Article] Preventive Effects of Quercetin against the Onset of Atherosclerosis-Related Acute Aortic Syndromes in Mice (2020)
  • Author(s): Kondo Masateru、Izawa-Ishizawa Yuki、Goda Mitsuhiro、Hosooka Mayuko、Kagimoto Yuu、Saito Naoko、Matsuoka Rie、Zamami Yoshito、Chuma Masayuki、Yagi Kenta、Takechi Kenshi、Tsuneyama Koichi、Ishizawa Keisuke
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 19 Pages: 7226-7226
  • DOI: 10.3390/ijms21197226
  • NAID: 120006891180
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors of immune checkpoint inhibitor-related interstitial lung disease in patients with lung cancer: a single-institution retrospective study (2020)
  • Author(s): Okada Naoto、Matsuoka Rie、Sakurada Takumi、Goda Mitsuhiro、Chuma Masayuki、Yagi Kenta、Zamami Yoshito、Nishioka Yasuhiko、Ishizawa Keisuke
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 13773-13773
  • DOI: 10.1038/s41598-020-70743-2
  • NAID: 120007190752
  • Peer Reviewed / Open Access
• [Journal Article] Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice (2020)
  • Author(s): Ikeda Yasumasa、Watanabe Hiroaki、Shiuchi Tetsuya、Hamano Hirofumi、Horinouchi Yuya、Imanishi Masaki、Goda Mitsuhiro、Zamami Yoshito、Takechi Kenshi、Izawa-Ishizawa Yuki、Miyamoto Licht、Ishizawa Keisuke、Aihara Ken-ichi、Tsuchiya Koichiro、Tamaki Toshiaki
  • Journal Title: Diabetologia Volume: 63 Issue: 8 Pages: 1588-1602
  • DOI: 10.1007/s00125-020-05153-0
  • NAID: 120007039998
  • Peer Reviewed
• [Journal Article] Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model. (2020)
  • Author(s): Masaki Imanishi, Yusuke Yamakawa, Keijo Fukushima, Raiki Ikuto, Akiko Maegawa, Yuki Izawa-Ishizawa, Yuya Horinouchi, Masateru Kondo, Masatoshi Kishuku, Mitsuhiro Goda, Yoshito Zamami, Kenshi Takechi, Masayuki Chuma, Yasumasa Ikeda, Koichiro Tsuchiya, Hiromichi Fujino, Koichi Tsuneyama, Keisuke Ishizawa
  • Journal Title: Naunyn-Schmiedeberg's Archives of Pharmacology Volume: - Issue: 7 Pages: 1239-1250
  • DOI: 10.1007/s00210-020-01859-5
  • Peer Reviewed / Open Access
• [Journal Article] Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway (2020)
  • Author(s): Hamano Hirofumi、Niimura Takahiro、Horinouchi Yuya、Zamami Yoshito、Takechi Kenshi、Goda Mitsuhiro、Imanishi Masaki、Chuma Masayuki、Izawa-Ishizawa Yuki、Miyamoto Licht、Fukushima Keijo、Fujino Hiromichi、Tsuchiya Koichiro、Ishizawa Keisuke、Tamaki Toshiaki、Ikeda Yasumasa
  • Journal Title: Toxicology Letters Volume: 318 Pages: 86-91
  • DOI: 10.1016/j.toxlet.2019.10.016
  • NAID: 120006894295
  • Peer Reviewed / Open Access
• [Journal Article] Rho-associated protein kinase and cyclophilin A are involved in inorganic phosphate-induced calcification signaling in vascular smooth muscle cells (2020)
  • Author(s): Tatsuya Tsuda, Masaki Imanishi, Mizuho Oogoshi, Yoshitaka Kihira, Yuya Horinouchi, Yoshito Zamami, Keisuke Ishizawa, Yasumasa Ikeda, Ichiro Hashimoto, Toshiaki Tamaki, Yuki Izawa-Ishizawa
  • Journal Title: Journal of Pharmacological Sciences Volume: 142 Issue: 3 Pages: 109-115
  • DOI: 10.1016/j.jphs.2019.12.005
  • NAID: 120006980541
  • Peer Reviewed / Open Access
• [Journal Article] Antibiotic prescriptions for Japanese outpatients with acute respiratory tract infections (2013-2015): A retrospective Observational Study (2020)
  • Author(s): Koyama Toshihiro、Hagiya Hideharu、Teratani Yusuke、Tatebe Yasuhisa、Ohshima Ayako、Adachi Mayu、Funahashi Tomoko、Zamami Yoshito、Tanaka Hiroyoshi Y.、Tasaka Ken、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 20 Issue: 7 Pages: 660-666
  • DOI: 10.1016/j.jiac.2020.02.001
• [Journal Article] Comparison of Hemorrhagic Risk between Prasugrel and Clopidogrel: a Retrospective Study using Adverse Drug Event Reporting Databases (2020)
  • Author(s): Hagiwara Hiromi、Fukuta Hidekatsu、Niimura Takahiro、Zamami Yoshito、Ishizawa Keisuke、Kimura Kazunori、Kamiya Takeshi、Ohte Nobuyuki
  • Journal Title: International Journal of Medical Sciences Volume: 17 Issue: 6 Pages: 728-733
  • DOI: 10.7150/ijms.43168
  • NAID: 120006956856
  • Peer Reviewed / Open Access
• [Journal Article] Association between rapid antigen detection tests and antibiotics for acute pharyngitis in Japan: A retrospective observational study (2019)
  • Author(s): Teratani Yusuke、Hagiya Hideharu、Koyama Toshihiro、Ohshima Ayako、Zamami Yoshito、Tatebe Yasuhisa、Tasaka Ken、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 25 Issue: 4 Pages: 267-272
  • DOI: 10.1016/j.jiac.2018.12.005
• [Journal Article] Iron accumulation causes impaired myogenesis correlated with MAPK signaling pathway inhibition by oxidative stress (2019)
  • Author(s): Ikeda Yasumasa、Satoh Akiho、Horinouchi Yuya、Hamano Hirofumi、Watanabe Hiroaki、Imao Mizuki、Imanishi Masaki、Zamami Yoshito、Takechi Kenshi、Izawa‐Ishizawa Yuki、Miyamoto Licht、Hirayama Tasuku、Nagasawa Hideko、Ishizawa Keisuke、Aihara Ken‐Ichi、Tsuchiya Koichiro、Tamaki Toshiaki
  • Journal Title: The FASEB Journal Volume: 33 Issue: 8 Pages: 9551-9564
  • DOI: 10.1096/fj.201802724rr
  • NAID: 120006847086
  • Peer Reviewed / Open Access
• [Journal Article] Nerve growth factor (NGF) has an anti-tumor effects through perivascular innervation of neovessels in HT1080 fibrosarcoma and HepG2 hepatitis tumor in nude mice (2019)
  • Author(s): Kawasaki Hiromu、Goda Mitsuhiro、Fukuhara Satoko、Hashikawa-Hobara Narumi、Zamami Yoshito、Takatori Shingo
  • Journal Title: Journal of Pharmacological Sciences Volume: 140 Issue: 1 Pages: 1-7
  • DOI: 10.1016/j.jphs.2019.02.011
  • NAID: 120006941130
  • Peer Reviewed
• [Journal Article] Oral anticoagulants usage in Japanese patients aged 18ー74 years with non-valvular atrial fibrillation: a retrospective analysis based on insurance claims data (2019)
  • Author(s): Ohshima Ayako、Koyama Toshihiro、Ogawa Aiko、Zamami Yoshito、Tanaka Hiroyoshi Y、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Miller Michael W、Kano Mitsunobu R
  • Journal Title: Family Practice Volume: in press Issue: 6 Pages: 685-692
  • DOI: 10.1093/fampra/cmz016
  • Peer Reviewed
• [Journal Article] Factors Associated With Immune Checkpoint Inhibitor?Related Myocarditis (2019)
  • Author(s): Zamami Yoshito、Niimura Takahiro、Okada Naoto、Koyama Toshihiro、Fukushima Keijo、Izawa-Ishizawa Yuki、Ishizawa Keisuke
  • Journal Title: JAMA Oncology Volume: 5 Issue: 11 Pages: 1635-1635
  • DOI: 10.1001/jamaoncol.2019.3113
  • Peer Reviewed / Open Access
• [Journal Article] Search for therapeutic agents for cardiac arrest using a drug discovery tool and large-scale medical information database (2019)
  • Author(s): Yoshito Zamami, Takahiro Niimura, Toshihiro Koyama, Yuta Shigemi, Yuki Izawa-Ishizawa, Ayako Ohshima, Keisaku Harada, Toru Imai, Hiromi Hagiwara, Naoto Okada, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Koichiro Tsuchiya, Yutaka Kondo, Shiro Hinotsu, Mitsunobu R Kano, Keisuke Ishizawa
  • Journal Title: Frontiers in Pharmacology Volume: 10 Pages: 109-115
  • DOI: 10.3389/fphar.2019.01257
  • NAID: 120006859989
  • Peer Reviewed / Open Access
• [Journal Article] Fall-related mortality trends in older Japanese adults aged ?65 years: a nationwide observational study (2019)
  • Author(s): Hagiya Hideharu、Koyama Toshihiro、Zamami Yoshito、Tatebe Yasuhisa、Funahashi Tomoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Hinotsu Shiro、Sendo Toshiaki、Rakugi Hiromi、Kano Mitsunobu R
  • Journal Title: BMJ Open Volume: 9 Issue: 12 Pages: e033462-e033462
  • DOI: 10.1136/bmjopen-2019-033462
  • NAID: 120006816628
  • Peer Reviewed / Open Access
• [Journal Article] Place of death trends among patients with dementia in Japan: a population-based observational study (2019)
  • Author(s): Koyama Toshihiro、Sasaki Misato、Hagiya Hideharu、Zamami Yoshito、Funahashi Tomoko、Ohshima Ayako、Tatebe Yasuhisa、Mikami Naoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Sendo Toshiaki、Hinotsu Shiro、Kano Mitsunobu R.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 41598-56388
  • DOI: 10.1038/s41598-019-56388-w
  • NAID: 120006875660
  • Peer Reviewed
• [Journal Article] Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study (2019)
  • Author(s): Okada Naoto、Kawazoe Hitoshi、Takechi Kenshi、Matsudate Yoshihiro、Utsunomiya Ryo、Zamami Yoshito、Goda Mitsuhiro、Imanishi Masaki、Chuma Masayuki、Hidaka Noriaki、Sayama Koji、Kubo Yoshiaki、Tanaka Akihiro、Ishizawa Keisuke
  • Journal Title: Clinical Therapeutics Volume: 41 Issue: 1 Pages: 59-67
  • DOI: 10.1016/j.clinthera.2018.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Potential Usefulness of Early Potassium Supplementation for Preventing Severe Hypokalemia Induced by Liposomal Amphotericin B in Hematologic Patients: A Retrospective Study (2018)
  • Author(s): Okada Naoto、Azuma Momoyo、Imanishi Masaki、Zamami Yoshito、Kirino Yasushi、Nakamura Toshimi、Teraoka Kazuhiko、Abe Masahiro、Ishizawa Keisuke
  • Journal Title: Clinical Therapeutics Volume: 40 Issue: 2 Pages: 252-260
  • DOI: 10.1016/j.clinthera.2017.12.006
• [Journal Article] Administration of Kampo medicine through a tube at an advanced critical care center (2018)
  • Author(s): Niimura Takahiro、Zamami Yoshito、Imai Toru、Ito Tsuyoshi、Sagara Hidenori、Hiroyuki Hichiya、Esumi Satoru、Takechi Kenshi、Imanishi Masaki、Koyama Toshihiro、Amano Manabu、Kurata Naomi、Kitamura Yoshihisa、Nakura Hironori、Sendo Toshiaki、Ishizawa Keisuke
  • Journal Title: The Journal of Medical Investigation Volume: 65 Issue: 1.2 Pages: 32-36
  • DOI: 10.2152/jmi.65.32
  • NAID: 130006575600
  • ISSN: 1343-1420, 1349-6867
• [Journal Article] Renoprotective effects of a factor Xa inhibitor : fusion of basic research and a database analysis (2018)
  • Author(s): Horinouchi Yuya、Ikeda Yasumasa、Fukushima Keijo、Imanishi Masaki、Hamano Hirofumi、Izawa-Ishizawa Yuki、Zamami Yoshito、Takechi Kenshi、Miyamoto Licht、Fujino Hiromichi、Ishizawa Keisuke、Tsuchiya Koichiro、Tamaki Toshiaki
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 10858
  • DOI: 10.1038/s41598-018-29008-2
  • NAID: 120006535061
  • URL: https://tokushima-u.repo.nii.ac.jp/records/2005594
  • Peer Reviewed / Open Access
• [Journal Article] Irinotecan-induced neutropenia is reduced by oral alkalization drugs: analysis using retrospective chart reviews and the spontaneous reporting database (2018)
  • Author(s): Hamano Hirofumi、Mitsui Marin、Zamami Yoshito、Takechi Kenshi、Nimura Takahiro、Okada Naoto、Fukushima Keijo、Imanishi Masaki、Chuma Masayuki、Horinouchi Yuya、Izawa-Ishizawa Yuki、Kirino Yasushi、Nakamura Toshimi、Teraoka Kazuhiko、Ikeda Yasumasa、Fujino Hiromichi、Yanagawa Hiroaki、Tamaki Toshiaki、Ishizawa Keisuke
  • Journal Title: Supportive Care in Cancer Volume: 27 Issue: 3 Pages: 849-856
  • DOI: 10.1007/s00520-018-4367-y
  • Peer Reviewed / Open Access
• [Journal Article] Development and pharmacist-mediated use of tools for monitoring atypical antipsychotic-induced side effects related to blood glucose levels (2018)
  • Author(s): Ishida Shunsuke、Takechi Kenshi、Bando Hiroshi、Imanishi Masaki、Zamami Yoshito、Chuma Masayuki、Yanagawa Hiroaki、Kirino Yasushi、Nakamura Toshimi、Teraoka Kazuhiko、Ishizawa Keisuke
  • Journal Title: Pharmacoepidemiology and Drug Safety Volume: 27 Issue: 12 Pages: 1379-1384
  • DOI: 10.1002/pds.4656
  • NAID: 120006723220
• [Journal Article] Nitrosonifedipine, a photodegradation product of nifedipine, suppresses pharmacologically induced aortic aneurysm formation (2018)
  • Author(s): Imanishi Masaki、Izawa-Ishizawa Yuki、Sakurada Takumi、Kohara Yusuke、Horinouchi Yuya、Sairyo Eriko、Zamami Yoshito、Takechi Kenshi、Chuma Masayuki、Fukushima Keijo、Ikeda Yasumasa、Fujino Hiromichi、Yoshizumi Masanori、Tsuchiya Koichiro、Tamaki Toshiaki、Ishizawa Keisuke
  • Journal Title: Pharmacology Volume: 102 Issue: 5-6 Pages: 287-299
  • DOI: 10.1159/000492577
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Polypharmacy in Japan: A Nationwide Retrospective Study (2018)
  • Author(s): Onoue Hiroshi、Koyama Toshihiro、Zamami Yoshito、Hagiya Hideharu、Tatebe Yasuhisa、Mikami Naoko、Shinomiya Kazuaki、Kitamura Yoshihisa、Hinotsu Shiro、Sendo Toshiaki、Ouchi Yasuyoshi、Kano Mitsunobu R.
  • Journal Title: Journal of the American Geriatrics Society Volume: 66 Issue: 12 Pages: 2267-2273
  • DOI: 10.1111/jgs.15569
• [Journal Article] Pharmacovigilance evaluation of the relationship between impaired glucose metabolism and BCR-ABL inhibitor use by using an adverse drug event reporting database (2018)
  • Author(s): Okada Naoto、Niimura Takahiro、Zamami Yoshito、Hamano Hirofumi、Ishida Shunsuke、Goda Mitsuhiro、Takechi Kenshi、Chuma Masayuki、Imanishi Masaki、Ishizawa Keisuke
  • Journal Title: Cancer Medicine Volume: 8 Issue: 1 Pages: 174-181
  • DOI: 10.1002/cam4.1920
  • NAID: 120006894607
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. (2018)
  • Author(s): Yoshito Zamami, Yuki Kouno, Takahiro Niimura, Masayuki Chuma, Toru Imai, Marin Mitsui, Toshihiro Koyama, Masahumi Kayano, Naoto Okada, Hirofumi Hamano, Mitsuhiro Goda, Masaki Imanishi, Kenshi Takechi, Yuya Horinouchi, Yutaka Kondo, Hiroaki Yanagawa, Yoshihisa Kitamura, Toshiaki Sendo, Yoshihito Ujike, Keisuke Ishizawa.
  • Journal Title: Pharmazie Volume: 73 Pages: 740-743
• [Presentation] 大規模医療情報データベースを活用した周術期領域における薬剤疫学研究 (2019)
  • Author(s): 座間味 義人, 石澤 有紀, 新村 貴博, 小山 敏広, 濱野 裕章, 岡田 直人, 合田 光寛, 武智 研志, 中馬 真幸, 堀ノ内 裕也, 桐野 靖, 中村 敏己, 寺岡 和彦, 石澤 啓介
  • Organizer: 第29回日本医療薬学会年会 シンポジウム9
  • Invited
• [Presentation] 大規模医療情報を活用した多施設共同臨床研究の提案 (2019)
  • Author(s): 座間味 義人, 新村 貴博, 川尻 雄大, 合田 光寛, 相澤 風花, 岡田 直人, 濱野 裕章, 武智 研志, 中馬 真幸, 石澤 有紀, 楊河 宏章, 石澤 啓介
  • Organizer: 第3回臨床薬理学集中講座フォローアップ・セミナー
  • Invited
• [Presentation] 医療ビッグデータ解析と基礎研究を融合した薬剤性副作用の機序解明および治療薬の開発 (2019)
  • Author(s): 新村 貴博, 座間味 義人, 石澤 有紀, 合田 光寛, 武智 研志, 中馬 真幸, 福島 圭穣, 堀ノ内 裕也, 池田 康将, 藤野 裕道, 土屋 浩一郎, 石澤 啓介
  • Organizer: 第29回日本医療薬学会年会 シンポジウム13
  • Invited
• [Presentation] 大規模医療情報データベースを活用したオキサリプラチン誘発末梢神経障害に対する予防薬探索 (2019)
  • Author(s): 合田 光寛, 座間味 義人, 新村 貴博, 川尻 雄大, 武智 研志, 中馬 真幸, 萱野 純史, 濱野 裕章, 岡田 直人, 小林 大介, 島添 隆雄, 石澤 有紀, 桐野 靖, 中村 敏己, 寺岡 和彦, 石澤 啓介
  • Organizer: 第29回日本医療薬学会年会 シンポジウム12
  • Invited
• [Presentation] ドラッグリポジショニング手法を用いたバンコマイシン関連腎障害の予防薬探索とその有用性の検討 (2019)
  • Author(s): 中馬 真幸, 合田 光寛, 谷 友歩, 座間味 義人, 武智 研志, 石澤 有紀, 濱野 裕章, 石田 俊介, 新村 貴博, 近藤 正輝, 坂東 貴司, 岡田 直人, 福島 圭穣, 藤野 裕道, 土屋 浩一郎, 堀ノ内 裕也, 池田 康将, 楊河 宏章, 石澤 啓介
  • Organizer: 第13回日本腎臓病薬物療法学会学術集会・総会
  • Invited
• [Presentation] 持続的腎代替療法 (2019)
  • Author(s): 中馬 真幸, 武智 研志, 座間味 義人, 合田 光寛, 岡田 直人, 近藤 正輝, 石澤 啓介, 楊河 宏章
  • Organizer: 第67回日本化学療法学会総会 シンポジウム10
  • Invited
• [Presentation] 免疫チェックポイント阻害薬の副作用発現及び治療効果に関連するバイオマーカーについて (2019)
  • Author(s): 岡田 直人, 座間味 義人, 武智 研志, 新村 貴博, 中馬 真幸, 合田 光寛, 石澤 啓介
  • Organizer: 医療薬学フォーラム2019／第27回クリニカルファーマシーシンポジウム シンポジウムS7
  • Invited
• [Presentation] Development of therapeutic agents using drug discovery tools and large-scale medical information (2019)
  • Author(s): Yoshito Zamami, Yuki Izawa-Ishizawa, Takahiro Niimura, Mitsuhiro Goda, Naoto Okada, Kenshi Takechi, Masayuki Chuma, Keijo Fukushima, Yuya Horinouchi, Yasumasa Ikeda, Hiromichi Fujino, Koichiro Tsuchiya, Keisuke Ishizawa
  • Organizer: FIP2019 Abu Dhabi
  • Int'l Joint Research
• [Presentation] Successful dose adjustment of vancomycin utilizing cystatin C in septic patients with bacterial meningitis: A case report (2019)
  • Author(s): Masayuki Chuma, Masateru Kondo, Yoshito Zamami, Kenshi Takechi, Mitsuhiro Goda, Naoto Okada, Akitomo Shibata, Mizuho Asada, Jun Oto, Hiroaki Yanagawa, Keisuke Ishizawa
  • Organizer: FIP2019 Abu Dhabi
  • Int'l Joint Research
• [Presentation] Nicorandil improve prognosis of cardiac arrest patient: A large-scale medical information analysis (2019)
  • Author(s): Takahiro Niimura, Yoshito Zamami, Yuki Izawa-Ishizawa, Mitsuhiro Goda, Kenshi Takechi, Masayuki Chuma, Keijo Fukushima, Yuya Horinouchi, Yasumasa Ikeda, Hiromichi Fujino, Koichiro Tsuchiya, Keisuke Ishizawa
  • Organizer: FIP2019 Abu Dhabi
  • Int'l Joint Research
• [Presentation] Effect of new preventive medicine on cisplatin-induced acute kidney injury (2019)
  • Author(s): Mitsuhiro Goda, Kazuhito Saike, Masaya Kanda, Takahiro Niimura, Kenshi Takechi, Masayuki Chuma, Yuki Izawa-Ishizawa, Yoshito Zamami, Keisuke Ishizawa
  • Organizer: EACPT2019 Stockholm
  • Int'l Joint Research
• [Presentation] 医療情報データベースを活用した抗がん剤誘発副作用に対する予防薬の探索研究 (2018)
  • Author(s): 座間味 義人、新村 貴博、石澤 有紀、武智 研志、今西 正樹、中馬 真幸、堀ノ内 裕也、池田 康将、土屋 浩一郎、石澤 啓介
  • Organizer: 21回日本医薬品情報学会総会・学術大会 シンポジウム12「有害事象自発報告データベースの薬剤疫学研究への活用法とその注意点」
  • Invited
• [Presentation] 大規模医療情報および生命科学データベースを活用したトランスレーショナルリサーチ (2018)
  • Author(s): 座間味 義人
  • Organizer: 第17回 亜鉛栄養治療研究会学術集会 会長推薦講演
  • Invited
• [Presentation] 大規模医療情報データベースおよび遺伝子発現データベースを活用した薬剤性心筋炎に対する予防薬の探索 (2018)
  • Author(s): 新村 貴博、座間味 義人、石澤 有紀、齊藤 広海、西牟田 剛広、今西 正樹、武智 研志、中馬 真幸、福島 圭穣、堀ノ内 裕也、池田 康将、藤野 裕道、土屋 浩一郎、石澤 啓介
  • Organizer: 第28回日本医療薬学会年会 シンポジウム62「教育から臨床、そして研究！リレーションにより副作用マネージメントの向上を目指す」
  • Invited
• [Presentation] 救急・集中治療領域において大規模医療情報データベースを活用したトランスレーショナルリサーチ (2018)
  • Author(s): 座間味 義人、石澤 有紀、新村 貴博、今西 正樹、武智 研志、中馬 真幸、堀ノ内 裕也、池田 康将、桐野 靖、中村 敏己、寺岡 和彦、石澤 啓介
  • Organizer: 第28回日本医療薬学会年会 シンポジウム40「救急・集中治療の臨床薬剤業務により見えてきたクリニカル・クエスチョンの解決― 最適な薬物治療の確立に向けて ―」
  • Invited
• [Presentation] 大規模医療情報データベースを活用した抗がん剤誘発副作用に対する予防薬の探索 (2018)
  • Author(s): 座間味 義人、川尻 雄大、新村 貴博、合田 光寛、岡田 直人、濱野 裕章、武智 研志、中馬 真幸、堀ノ内 裕也、石澤 有紀、池田 康将、小林 大介、島添 隆雄、石澤 啓介
  • Organizer: 第92回日本薬理学会年会 年会企画シンポジウム「医療ビッグデータに基づく薬理学研究」
  • Invited
• [Presentation] ３段階の学年積み上げ式多職種連携教育 (2018)
  • Author(s): 座間味義人、濱野 裕章、川原 里枝子、木内 恵里、合田 光寛、岡田 直人、柴田 高洋、今西 正樹、桐野 靖、中村 敏己、寺岡 和彦、吾妻 雅彦、石澤 啓介
  • Organizer: 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会 特別シンポジウム
  • Invited
• [Presentation] Search for drugs that attenuate the antitumor effect of bevacizumab using adverse event database (2018)
  • Author(s): Yoshito Zamami, Yuki Izawa-Ishizawa, Kenshi Takechi, Masaki Imanishi, Keijo Fukushima, Yuya Horinouchi, Yasumasa Ikeda, Hiromichi Fujino, Toshiaki Tamaki, Keisuke Ishizawa
  • Organizer: WCP2018
  • Int'l Joint Research
• [Presentation] Drug repositioning for post cardiopulmonary resuscitation syndrome using large-scale medical claims (2018)
  • Author(s): Yoshito Zamami, Yuki Izawa-Ishizawa, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Masayuki Chuma, Yuya Horinouchi, Yasumasa Ikeda, Koichiro Tsuchiya, Keisuke Ishizawa
  • Organizer: FIP2018
  • Int'l Joint Research