Elucidation of the pathological mechanism of the onset of equilibrium sensory dysfunction through gap junctions of inner ear vestibular hair cells
| Project/Area Number |
18K06906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48030:Pharmacology-related
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山口 太郎 摂南大学, 薬学部, 講師 (30710701)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 平衡感覚障害 / 内耳前庭 / 有毛細胞 / ギャップ結合 / 前庭 / 平衡感覚 / 内耳 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the pathological mechanism of the onset of equilibrium sensory dysfunction through the elucidation of the functional role of the onset of equilibrium sensory dysfunction and the gap junction of vestibular hair cells. Treatment with carbenoxolone (CBX), a gap junction inhibitor into the inner ear of mice, caused morphological abnormalities of vestibular hair cells and reduced gap junction function. Antioxidants tempol and NAC tended to suppress the decline in gap junction function due to CBX treatment.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、平衡感覚には前庭におけるギャップ結合が重要な役割をもつことが明らかとなり、前庭有毛細胞のギャップ結合の機能的破綻が平衡感覚機能障害を発症することが示唆されたことは学術的に重要な意味をもつものである。また、平衡感覚機能障害に対して、抗酸化作用をもつ薬物が有効かつ効果的である可能性を見出したことは新たな治療薬開発において重要かつ社会的ニーズの高いものであり社会的意義は高い。
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice.2020
Author(s)
1.Pham HTN, Tran HN, Nguyen PT, Le XT, Nguyen KM, Phan SV, Yoneyama M, Ogita K, Yamaguchi T, Folk WR, Yamaguchi M, Matsumoto K.
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Journal Title
International Journal of Molecular Sciences
Volume: 21
Issue: 9
Pages: 3365-3365
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] <i>Bacopa monnieri</i> (L.) Ameliorates Cognitive Deficits Caused in a Trimethyltin-Induced Neurotoxicity Model Mice2019
Author(s)
Pham HTN, Phan SV, Tran HN, Phi XT, Le XT, Nguyen KM, Fujiwara H, Yoneyama M, Ogita K, Yamaguchi T, Matsumoto K
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 42
Issue: 8
Pages: 1384-1393
DOI
NAID
ISSN
0918-6158, 1347-5215
Year and Date
2019-08-01
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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