| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Vaccination is a possible strategy for preventing new HTLV-1 infections, as HTLV-1 infection is neutralized by antibodies against the Env protein, and vaccination with the Env protein as antigen is expected to have a protective effect against infection. Female BALB/c mice were vaccinated with recombinant Env protein (rEnv) as antigen by a baculovirus expression system, subcutaneously with adjuvant twice at 3-week intervals, followed by an additional vaccination with rEnv only, and then mated. IgG antibody titers in sera obtained over time from the mother and pups after birth and birth revealed that the pups' sera had higher rEnv-specific antibody titers than the mother's sera.
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