Elucidation of the mechanism of action of the olfactory receptor involved in cancer-specific metabolism
| Project/Area Number |
18K07060
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 49030:Experimental pathology-related
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
Takei Norio 北海道大学, 医学研究院, 助教 (50523461)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
太田 明伸 愛知医科大学, 医学部, 講師 (30438048)
桜井 敬之 信州大学, 学術研究院医学系, 准教授 (80317825)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | GPCR / ワールブルグ効果 / 癌 / 糖代謝 / CRISPR/Cas9 / 嗅受容体 / CRISPR./Cas9 / OR7C1 / Warburg effect / GCPR / olfactory receptor / cancer / warburg effect |
|---|
| Outline of Final Research Achievements |
In glucose metabolism, cancer cells are known to have a predominant energy metabolism by glycolysis, even in an aerobic environment, as compared to normal cells. This property has been suggested to be associated with malignant tumors of cancer in various stress environments within the tumor.
In this study, we focused on the characteristic metabolic pathways of cancer that differ from these normal cells and conducted a study about the role of a orphan receptor, which is thought to be involved in its metabolism, and the verification of therapeutic effect of its inhibition. This result suggested that this molecule may be involved in the regulation of major metabolic enzymes in cancer-specific energy metabolic pathways, and expected to be a novel target molecule in cancer treatment.
|
| Academic Significance and Societal Importance of the Research Achievements |
申請者は、癌の特殊なエネルギー代謝として知られ、癌の悪性化に影響を及ぼす可能性が示されているワールブルグ効果に着目し、その機構への関連が示唆される分子の機能を解明し治療への応用が可能かの基礎的知見を示した。
癌細胞は正常の細胞とは異なり、高い増殖能と分化・転移能を有しており、生物学的に癌細胞においてそのような悪性化に影響をおよぼす因子は治療標的・診断マーカーとなる可能性があることから、それらに関与する新規の因子を同定し、その役割を明らかにすることは、新しい治療法や診断法の開発に有用である。
|
Report
(4 results)
Research Products
(9 results)
