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Elucidation of the role of bile acids and short-chain fatty acids in the onset and progression of non-alcoholic steatohepatitis

Research Project

Project/Area Number 18K07069
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49030:Experimental pathology-related
Research InstitutionThe University of Tokushima

Principal Investigator

TSUNEYAMA Koichi  徳島大学, 大学院医歯薬学研究部(医学域), 教授 (10293341)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords非アルコール性脂肪肝炎 / 胆汁酸 / 短鎖脂肪酸 / ラマン顕微鏡 / 動物モデル / NASH / 肝細胞癌 / 質量分析 / 非アルコール性脂肪性肝炎 / イメージング質量分析
Outline of Final Research Achievements

We succeeded in inducing characteristic fibrosis mimic to human non-alcoholic steatohepatitis in the liver by adding cholic acid to mice on a high-fat / high-cholesterol diet. We analyzed the lipid droplets accumulated in hepatocytes and the surrounding microenvironment with a Raman microscope or imaging mass spectrometry. It was clarified that specific lipids were associated with fibrosis through the activation of macrophages. In addition, various oligosaccharides were administered to TSOD mice spontaneously developing metabolic syndrome. As expected, oligosaccharide administration improved blood glucose level, urinary sugar, and liver histology. Oligosaccharides have positively affected intestinal bacterial flora, and improvement of short-chain fatty acids was identified. It has been suggested the possibility of dietary NASH prevention and treatment.

Academic Significance and Societal Importance of the Research Achievements

メタボリックシンドロームの肝表現型である非アルコール性脂肪肝炎(NASH)は患者数が急増している難治性疾患である。研究代表者は脂質と胆汁酸を交えた食によって、マウスにヒトと類似したNASH-線維化を誘導することに成功し、これらモデル動物を用いてNASHの線維化に異常脂質や胆汁酸が関与していることを明らかにした。さらに食の成分であるオリゴ糖の投与によって腸内環境の改善による短鎖脂肪酸のバランス是正が生じ、NASHの病態が改善することを見出した。本研究はNASHの発症進展や病態改善がいずれも食によってコントロールできる可能性を示したものであり、NASHの全容解明に有用な知見と考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (60 results)

All 2020 2019 2018 Other

All Int'l Joint Research (4 results) Journal Article (33 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 33 results,  Open Access: 15 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 16 results)

  • [Int'l Joint Research] カリフォルニア大学デービス校(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] 華南理工大学(中国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of California, Davis(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] South China University of Technology(中国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus2020

    • Author(s)
      Andoh Tsugunobu、Suzuki Kazunari、Konno Mitsuhiro、Tsuneyama Koichi、Kuraishi Yasushi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 43 Issue: 7 Pages: 1111-1117

    • DOI

      10.1248/bpb.b20-00097

    • NAID

      130007867928

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2020-07-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel mouse model of diet-induced nonalcoholic steatohepatitis-related progressive bridging fibrosis2020

    • Author(s)
      Ichimura-Shimizu Mayuko、Omagari Katsuhisa、Yamashita Michiko、Tsuneyama Koichi
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 4 Pages: 941-947

    • DOI

      10.1093/bbb/zbaa107

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular imaging analysis of microvesicular and macrovesicular lipid droplet in non-alcoholic fatty liver disease by Raman microscopy.2020

    • Author(s)
      Minamikawa T, Ichimura-Shimizu M, Takanari H, Morimoto Y, Shiomi R, Tanioka H, Hase E, Yasui T, Tsuneyama K.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 18548-18548

    • DOI

      10.1038/s41598-020-75604-6

    • NAID

      120006959724

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of liver and blood miRNA in precancerous conditions2020

    • Author(s)
      Umezu Tomohiro、Tsuneyama Koichi、Kanekura Kohsuke、Hayakawa Michiyo、Tanahashi Toshihito、Kawano Mitsuoki、Taguchi Y-h、Toyoda Hidenori、Tamori Akihiro、Kuroda Masahiko、Murakami Yoshiki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21766-21766

    • DOI

      10.1038/s41598-020-78500-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of sphingosine 1-phosphate by hepatobiliary cholesterol handling2020

    • Author(s)
      Kurano Makoto、Tsukamoto Kazuhisa、Hara Masumi、Tsuneyama Koichi、Nishikawa Takako、Ikeda Hitoshi、Yatomi Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 11 Pages: 14655

    • DOI

      10.1096/fj.202001397r

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice2020

    • Author(s)
      Oda Shingo、Miyazaki Nanaka、Tsuneyama Koichi、Yokoi Tsuyoshi
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 45 Issue: 8 Pages: 493-502

    • DOI

      10.2131/jts.45.493

    • NAID

      130007884274

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Smad Phospho-Isoforms for Hepatocellular Carcinoma Risk Assessment in Patients with Nonalcoholic Steatohepatitis2020

    • Author(s)
      Suwa Kanehiko、Yamaguchi Takashi、Yoshida Katsunori、Murata Miki、Ichimura Mayuko、Tsuneyama Koichi、Seki Toshihito、Okazaki Kazuichi
    • Journal Title

      Cancers

      Volume: 12 Issue: 2 Pages: 286-286

    • DOI

      10.3390/cancers12020286

    • NAID

      120006894613

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis2020

    • Author(s)
      Takai Atsuko、Kikuchi Kentaro、Ichimura Mayuko、Tsuneyama Koichi、Moritoki Yuki、Matsumoto Kotaro、Tsunashima Hiromichi、Onda Takeshi、Kuniyoshi Noriyuki、Nariyama Tomoyuki、Ohyatsu Sho、Kubota Juri、Nagumo Kozue、Sato Shinpei、Hara Masumi、Miyakawa Hiroshi
    • Journal Title

      BMC Gastroenterology

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12876-020-01194-2

    • NAID

      120006842035

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Age-Related Alterations of Nonalcoholic Steatohepatitis in Sprague-Dawley Rats Fed a High-Fat and High-Cholesterol Diet2019

    • Author(s)
      OMAGARI Katsuhisa、ASAKAWA Eri、SASAO Marin、NARITA Sumire、HISANO Mei、FUKUDA Ayumi、SURUGA Kazuhito、ICHIMURA Mayuko、TSUNEYAMA Koichi
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 65 Issue: 4 Pages: 349-356

    • DOI

      10.3177/jnsv.65.349

    • NAID

      130007697552

    • ISSN
      0301-4800, 1881-7742
    • Year and Date
      2019-08-31
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatic Campylobacter jejuni infection in patients with Castleman‐Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome)2019

    • Author(s)
      Kageyama Chihiro、Igawa Takuro、Gion Yuka、Iwaki Noriko、Tabata Tetsuya、Tanaka Takehiro、Kondo Eisei、Sakai Hajime、Tsuneyama Koichi、Nomoto Kazuhiro、Noguchi Hiroko、Yoshino Tadashi、Yokota Kenji、Sato Yasuharu
    • Journal Title

      Pathology International

      Volume: 69 Issue: 10 Pages: 572-579

    • DOI

      10.1111/pin.12856

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms2019

    • Author(s)
      Matsumoto Minoru、Tsuneyama Koichi、Morimoto Junko、Hosomichi Kazuyoshi、Matsumoto Mitsuru、Nishijima Hitoshi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 2 Pages: 117-131

    • DOI

      10.1093/intimm/dxz066

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary fat, cholesterol, and cholic acid affect the histopathologic severity of nonalcoholic steatohepatitis in Sprague-Dawley rats2019

    • Author(s)
      Fukuda Ayumi、Sasao Marin、Asakawa Eri、Narita Sumire、Hisano Mei、Suruga Kazuhito、Ichimura Mayuko、Tsuneyama Koichi、Tanaka Kazunari、Omagari Katsuhisa
    • Journal Title

      Pathology - Research and Practice

      Volume: 215 Issue: 11 Pages: 152599-152599

    • DOI

      10.1016/j.prp.2019.152599

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The challenges of primary biliary cholangitis: What is new and what needs to be done2019

    • Author(s)
      Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Bowlus C, Carbone M, Chazouill O, et al.
    • Journal Title

      Journal of Autoimmunity

      Volume: 105 Pages: 102328-102328

    • DOI

      10.1016/j.jaut.2019.102328

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two cases of non-mucinous cystadenomas of the pancreas with pancreatobiliary phenotype and ovarian-like stroma2019

    • Author(s)
      Yamashita Shoko、Ikemoto Tetsuya、Morine Yuji、Imura Satoru、Iwahashi Shuichi、Saito Yu、Yamada Shinichiro、Yoshimoto Toshiaki、Tsuneyama Koichi、Shimada Mitsuo
    • Journal Title

      Surgical Case Reports

      Volume: 5 Issue: 1 Pages: 117-117

    • DOI

      10.1186/s40792-019-0673-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment of a mouse model of troglitazone‐induced liver injury and analysis of its hepatotoxic mechanism2019

    • Author(s)
      Jia Ru、Oda Shingo、Tsuneyama Koichi、Urano Yuya、Yokoi Tsuyoshi
    • Journal Title

      Journal of Applied Toxicology

      Volume: 39 Issue: 11 Pages: 1541-1556

    • DOI

      10.1002/jat.3838

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3?cells via upregulating γ-glutamyl cyclotransferase expression2019

    • Author(s)
      Takahashi Tetsuyuki、Ichikawa Hirona、Morimoto Yuuki、Tsuneyama Koichi、Hijikata Takao
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 516 Issue: 2 Pages: 388-396

    • DOI

      10.1016/j.bbrc.2019.06.054

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of amino acid profiles of blood over time and biomarkers associated with non-alcoholic steatohepatitis in STAM mice2019

    • Author(s)
      Iida Ayaka、Kuranuki Sachi、Yamamoto Ryoko、Uchida Masaya、Ohta Masanori、Ichimura Mayuko、Tsuneyama Koichi、Masaki Takayuki、Seike Masataka、Nakamura Tsuyoshi
    • Journal Title

      Experimental Animals

      Volume: 68 Issue: 4 Pages: 417-428

    • DOI

      10.1538/expanim.18-0152

    • NAID

      130007742195

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental Evidence of Liver Injury by BSEP-Inhibiting Drugs With a Bile Salt Supplementation in Rats2019

    • Author(s)
      Yang Fuhua、Takeuchi Taiki、Tsuneyama Koichi、Yokoi Tsuyoshi、Oda Shingo
    • Journal Title

      Toxicological Sciences

      Volume: in press Issue: 1 Pages: 95-108

    • DOI

      10.1093/toxsci/kfz088

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macrophage‐specific hypoxia‐inducible factor‐1α deletion suppresses the development of liver tumors in high‐fat diet‐fed obese and diabetic mice2019

    • Author(s)
      Takikawa Akiko、Usui Isao、Fujisaka Shiho、Tsuneyama Koichi、Okabe Keisuke、Nakagawa Takashi、Nawaz Allah、Kado Tomonobu、Jojima Teruo、Aso Yoshimasa、Hayakawa Yoshihiro、Yagi Kunikimi、Tobe Kazuyuki
    • Journal Title

      Journal of Diabetes Investigation

      Volume: in press Issue: 6 Pages: 1-8

    • DOI

      10.1111/jdi.13047

    • NAID

      120006980551

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apolipoprotein M suppresses the phenotypes of IgA nephropathy in hyper-IgA mice2019

    • Author(s)
      Kurano Makoto、Tsuneyama Koichi、Morimoto Yuki、Nishikawa Masako、Yatomi Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 4 Pages: 5181-5195

    • DOI

      10.1096/fj.201801748r

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a novel aortic dissection mouse model and evaluation of drug efficacy using in-vivo assays and database analyses2019

    • Author(s)
      Izawa-Ishizawa Yuki、Imanishi Masaki、Zamami Yoshito、Toya Hiroki、Nagao Tomoko、Morishita Marin、Tsuneyama Koichi、Horinouchi Yuya、Kihira Yoshitaka、Takechi Kenshi、Ikeda Yasumasa、Tsuchiya Koichiro、Yoshizumi Masanori、Tamaki Toshiaki、Ishizawa Keisuke
    • Journal Title

      Journal of Hypertension

      Volume: 37 Issue: 1 Pages: 73-83

    • DOI

      10.1097/hjh.0000000000001898

    • NAID

      120006627861

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of 2-Picolylamine Derivatized Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry for the Determination of Short-chain Fatty Acids in Feces Samples2018

    • Author(s)
      NAGATOMO Ryosuke、OKADA Yasuki、ICHIMURA Mayuko、TSUNEYAMA Koichi、INOUE Koichi
    • Journal Title

      Analytical Sciences

      Volume: 34 Issue: 9 Pages: 1031-1036

    • DOI

      10.2116/analsci.18SCP10

    • NAID

      130007474699

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2018-09-10
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-drug antibodies against a novel humanized anti-CD20 antibody impair its therapeutic effect on primary biliary cholangitis in human CD20- and FcγR-expressing mice2018

    • Author(s)
      Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M.
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Issue: NOV Pages: 2534-2534

    • DOI

      10.3389/fimmu.2018.02534

    • NAID

      120006937682

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G2018

    • Author(s)
      Morimoto Junko、Nishikawa Yumiko、Kakimoto Takumi、Furutani Kohei、Kihara Naoki、Matsumoto Minoru、Tsuneyama Koichi、Kozono Yuko、Kozono Haruo、Hozumi Katsuto、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru
    • Journal Title

      The Journal of Immunology

      Volume: 201 Issue: 11 Pages: 3244-3257

    • DOI

      10.4049/jimmunol.1800950

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome2018

    • Author(s)
      Nishitsuji Kazuchika、Watanabe Syunsuke、Xiao Jinzhong、Nagatomo Ryosuke、Ogawa Hirohisa、Tsunematsu Takaaki、Umemoto Hitomi、Morimoto Yuki、Akatsu Hiroyasu、Inoue Koichi、Tsuneyama Koichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16173-16173

    • DOI

      10.1038/s41598-018-34571-9

    • NAID

      120006842036

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota translocation promotes autoimmune cholangitis2018

    • Author(s)
      Ma Hong-Di、Zhao Zhi-Bin、Ma Wen-Tao、Liu Qing-Zhi、Gao Cai-Yue、Li Liang、Wang Jinjun、Tsuneyama Koichi、Liu Bin、Zhang Weici、Zhou Yongjian、Gershwin M. Eric、Lian Zhe-Xiong
    • Journal Title

      Journal of Autoimmunity

      Volume: 95 Pages: 47-57

    • DOI

      10.1016/j.jaut.2018.09.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice2018

    • Author(s)
      Urano Yuya、Oda Shingo、Tsuneyama Koichi、Yokoi Tsuyoshi
    • Journal Title

      Chemico-Biological Interactions

      Volume: 296 Pages: 185-197

    • DOI

      10.1016/j.cbi.2018.09.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neutrophils induce smooth muscle hyperplasia via neutrophil elastase‐induced FGF‐2 in a mouse model of asthma with mixed inflammation2018

    • Author(s)
      Ogawa Hirohisa、Azuma Masahiko、Tsunematsu Takaaki、Morimoto Yuuki、Kondo Mayo、Tezuka Toshifumi、Nishioka Yasuhiko、Tsuneyama Koichi
    • Journal Title

      Clinical & Experimental Allergy

      Volume: 48 Issue: 12 Pages: 1715-1725

    • DOI

      10.1111/cea.13263

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet2018

    • Author(s)
      Katsuhisa Omagari, Kazuhito Suruga, Akira Kyogoku, Satomi Nakamura, Ai Sakamoto, Shinta Nishioka, Mayuko Ichimura, Yuji Miyata, Koichi Tajima, Koichi Tsuneyama, Kazunari Tanaka
    • Journal Title

      Hepatobiliary Surgery and Nutrition

      Volume: - Issue: 3 Pages: 175-184

    • DOI

      10.21037/hbsn.2017.08.03

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue-Resident Memory CD8+ T Cells Acting as Mediators of Salivary Gland Damage in a Murine Model of Sjogren's Syndrome2018

    • Author(s)
      Gao Cai-Yue、Yao Yuan、Li Liang、Yang Shu-Han、Chu Hui、Tsuneyama Koichi、Li Xiao-Mei、Gershwin M. Eric、Lian Zhe-Xiong
    • Journal Title

      Arthritis & Rheumatology

      Volume: 71 Issue: 1 Pages: 121-132

    • DOI

      10.1002/art.40676

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS2018

    • Author(s)
      Takeuchi Masaki、Oda Shingo、Tsuneyama Koichi、Yokoi Tsuyoshi
    • Journal Title

      Archives of Toxicology

      Volume: 92 Issue: 9 Pages: 2947-2962

    • DOI

      10.1007/s00204-018-2269-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin2018

    • Author(s)
      Akiko Matsubara, Shingo Oda, Sho Akai, Koichi Tsuneyama, Tsuyoshi Yokoi
    • Journal Title

      Toxicology Letters

      Volume: 291 Pages: 184-193

    • DOI

      10.1016/j.toxlet.2018.04.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.2018

    • Author(s)
      Kurano M, Tsuneyama K, Morimoto Y, Shimizu T, Jona M, Kassai H, Nakao K, Aiba A, Yatomi Y
    • Journal Title

      Thromb Haemost.

      Volume: 印刷中 Issue: 06 Pages: 1021-1035

    • DOI

      10.1055/s-0038-1641750

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 非アルコール性脂肪肝炎患者のリン酸化Smadによる肝発癌のリスク評価2020

    • Author(s)
      諏訪 兼彦, 山口 隆志, 吉田 勝紀, 村田 美樹, 清水 真祐子, 常山 幸一, 関 寿人, 岡崎 和一
    • Organizer
      日本肝臓学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] NASH線維化の定量的評価のための基礎的研究2020

    • Author(s)
      清水 真祐子, 富永 俊弼, 常山 幸一
    • Organizer
      日本肝臓学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 実験的モデル動物作成に用いられる高脂肪・コレステロール食に含まれるコール酸のNASH病態形成への影響2020

    • Author(s)
      市村 真祐子, 大曲 勝久, 常山 幸一
    • Organizer
      日本肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] NASH線維化肝におけるpathogen lipidsの同定2020

    • Author(s)
      市村 真祐子, 松本 穣, 尾矢 剛志, 小川 博久, 常山 幸一, 平 修
    • Organizer
      徳島医学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 探針エレクトロスプレーイオン化質量分析(PESI-MS)の病理診断・細胞診への応用2020

    • Author(s)
      常山幸一
    • Organizer
      日本画像医学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] AIと分子病理学の新展開2020

    • Author(s)
      常山幸一
    • Organizer
      徳島医学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] AIと光を駆使したがん細胞診断2020

    • Author(s)
      常山幸一
    • Organizer
      未来へのバイオ技術勉強会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 質量分析イメージングと形態学の接点2019

    • Author(s)
      常山幸一
    • Organizer
      臨床細胞学会秋期大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 自然発症メタボリックシンドローム-NASH-HCCモデルマウスにおけるプレバイオティクスによる腸内細菌叢への介入効果の検討2019

    • Author(s)
      常山幸一
    • Organizer
      第30回日本消化器癌発生学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 免疫チェックポイント阻害薬による薬物性肝障害の病理2019

    • Author(s)
      常山幸一
    • Organizer
      基臨の会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Development of a new diagnostic method for steatohepatitis by analysis of serum composition using atmospheric pressure mass spectrometry2019

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      PESI 研究会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] シェーグレン症候群と原発性胆汁性胆管炎の病理学的類似性2019

    • Author(s)
      常山幸一
    • Organizer
      第28回日本シェーグレン症候群学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 線維化組織の詳細な評価を可能にする新たなモダリティSHG2019

    • Author(s)
      常山幸一
    • Organizer
      日本法医病理学会学術全国集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 免疫チェックポイント阻害薬による肝障害を来した4例の病理学的特徴2019

    • Author(s)
      常山幸一
    • Organizer
      日本肝臓学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] NASH周辺・関連疾患の病理2019

    • Author(s)
      常山幸一
    • Organizer
      日本病理学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ヒトに近い病態を示す新規NASHモデル動物の開発と応用2019

    • Author(s)
      常山幸一
    • Organizer
      日本薬学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Pathological features of new animal models for primary biliary cholangitis2019

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      Prof.M.Eric Gershwin Symposium
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Novel animal models for analyzing metabolic syndrome-associated liver disease2019

    • Author(s)
      常山幸一
    • Organizer
      2019 SCUT INTERNATIONAL SYMPOSIUM OF LIVER IMMUNOLOGY
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 肝腫瘍の病理学的特徴と鑑別診断:興味深い症例を中心に2018

    • Author(s)
      常山幸一
    • Organizer
      和歌山腫瘍研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] PBC animal model2018

    • Author(s)
      Koichi Tsuneyama
    • Organizer
      The Lugano meeting
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 肝臓病理所見のとり方とその解釈 ~疾患モデル動物が教えてくれること~2018

    • Author(s)
      常山幸一
    • Organizer
      法医病理学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 病理学的なものの見方・考え方のススメ ~病理・形態学をハブとした研究者ネットワークの構築とその先に~2018

    • Author(s)
      常山幸一
    • Organizer
      関東リトリート(金沢)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] NAFLDの病理診断の動向2018

    • Author(s)
      常山幸一
    • Organizer
      日本超音波医学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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