Involvement of melanocortin type 1 receptor dysfunction in pancreatic carcinogenesis
| Project/Area Number |
18K07081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Takahashi Mami 国立研究開発法人国立がん研究センター, 研究所, ユニット長 (90214973)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵臓がん / メラノコルチン受容体 / 一塩基多型 / SNPs / 細胞株 / マウスモデル |
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| Outline of Final Research Achievements |
We examined single nucleotide polymorphisms (SNPs) of the MC1R gene in pancreatic cancer cell lines of Caucasian origin and found that 5 of 8 lines (62.5%) had dominant variants of the red hair and fair skin type, being highly frequent compared to the percentage observed in European people (26%). On the other hand, analysis of MC1R SNPs in 72 pancreatic cancer cell lines derived from Japanese patients revealed that one of the recessive variants, which is common in Japanese, was found in both alleles in 69% of the cell lines, significantly higher than that in the general Japanese population (54%). MC1R variant is a possible risk factor for pancreatic cancer. However, analysis using Mc1r<e/e> mice with the Mc1r variant showed no apparent effect on carcinogenesis or tumor growth.
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| Academic Significance and Societal Importance of the Research Achievements |
日本人の膵がん患者では欧米人とは異なり、MC1Rの潜性バリアントを両アレルに有していることが多いことが示されたことから、その特徴に応じた日本人に適した治療法の開発に貢献できる可能性がある。
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Report
(6 results)
Research Products
(16 results)
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[Journal Article] Effect of fucoxanthinol on pancreatic ductal adenocarcinoma cells from an N-nitrosobis(2-oxopropyl)amine-initiated Syrian golden hamster pancreatic carcinogenesis model.2021
Author(s)
Terasaki, M., Nishizaka, Y., Murase, W., Kubota, A., Kojima, H., Kojoma M., Tanaka, T., Maeda, H., Miyashita, K., Mutoh, M., Takahashi, M.
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Journal Title
Cancer Genomics Proteomics
Volume: 18
Issue: 3 Suppl
Pages: 407-423
DOI
Related Report
Peer Reviewed
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[Journal Article] A fucoxanthinol induces apoptosis in a pancreatic intraepithelial neoplasia cells.2021
Author(s)
Terasaki, M., Takuya Inoue, T., Murase, W., Atsuhito Kubota, A., Kojma, H., Kojoma, M., Ohta, T., Maeda, H., Miyashita, K., Mutoh, M., Takahashi, M.
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Journal Title
Cancer Genomics Proteomics
Volume: 18
Issue: 2
Pages: 133-146
DOI
Related Report
Peer Reviewed / Open Access
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