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Development of an optimal diagnostic system for parasitic diseases

Research Project

Project/Area Number 18K07090
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49040:Parasitology-related
Research InstitutionUniversity of Miyazaki

Principal Investigator

Maruyama Haruhiko  宮崎大学, 医学部, 教授 (90229625)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords寄生虫症 / 症候 / 鑑別診断 / 好酸球増多 / 抗体検査 / 寄生虫 / 診断 / 感度 / 特異度 / スクリーニング検査 / 確定診断 / スクリーニング / 臨床研究 / 組換え抗原 / 検査 / 的中率
Outline of Final Research Achievements

We analyzed clinical information and test results at our laboratory of 3,085 patients, who had been suspected as having parasitic infections. The most frequent symptom was pulmonary complaints and/or chest abnormal imaging, followed by abdominal symptoms, neurological disorder, and visual disorders. Peripheral blood eosinophilia or local eosinophil infiltration were noted in 54.5% of patients. Based on our laboratory tests, including measuring anti-parasite antibodies, infection-positive ratio was most high in creeping eruption (70.2%), followed by subcutaneous tumor (65.4%), and abnormal hepatic imaging (65.4%). When eosinophilia was accompanied with these symptoms, positive ratios were higher by approx. 10%.

Academic Significance and Societal Importance of the Research Achievements

線虫や条虫、吸虫による寄生虫症は疾患としては単純であり、正しく診断がつけばほとんどの場合に治療は容易である。ところがごく稀にしか遭遇しないため、一般臨床医にとっては典型的な苦手感染症になっている。本研究は、現在の日本の日常診療の中で、どのような訴えや所見がある場合にどのような寄生虫症の確率が高いのかを明らかにした。また同時に、虫体由来抗原または組換え寄生虫抗原を用いた信頼性の高い系を確立した。これらを組み合わせることにより、誰がどの医療機関を受診しても、正しく寄生虫症の診断に到達するような診断プロトコルの策定が可能となった。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (21 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (11 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 11 results,  Open Access: 6 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Int'l Joint Research] KEMRI(ケニア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Medicine, 1(ミャンマー)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Vietnam Acad Sci Tech (VAST)(ベトナム)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] University of Medicine 1/University of Medicine 2(ミャンマー)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Universidad Peruana Cayetano Heredia(ペルー)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Primaquine plus clindamycin as a promising salvage therapy for Pneumocystis jirovecii pneumonia: A retrospective analysis in Japanese patients2021

    • Author(s)
      Koga Michiko、Suganuma Akihiko、Kikuchi Tadashi、Yoshimura Yukihiro、Shoji Kensuke、Kobayashi Ichiro、Takezaki Shunichiro、Kato Yasuyuki、Kimura Mikio、Maruyama Haruhiko
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 6 Pages: 924-928

    • DOI

      10.1016/j.jiac.2021.03.001

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enzyme-linked immunosorbent assay (ELISA) using recombinant Fasciola cathepsin L1 for the diagnosis of human fasciolosis caused by Fasciola hepatica/gigantica hybrid type.2021

    • Author(s)
      Sugiyama T, Ichikawa-Seki M, Sato H, Kounosu A, Tanaka M, Maruyama H
    • Journal Title

      Parasitology International

      Volume: 82 Pages: 102311-102311

    • DOI

      10.1016/j.parint.2021.102311

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas.2021

    • Author(s)
      Tanaka M, Kildemoes AO, Chadeka EA, Cheruiyot BN, Sassa M, Moriyasu T, Nakamura R, Kikuchi M, Fujii Y, de Dood CJ, Corstjens PLAM, Kaneko S, Maruyama H, Njenga SM, de Vrueh R, Hokke CH, Hamano S
    • Journal Title

      Parasitology International

      Volume: 83 Pages: 102346-102346

    • DOI

      10.1016/j.parint.2021.102346

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Seroprevalence of toxoplasmosis among reproductive-aged women in Myanmar and evaluation of luciferase immunoprecipitation system assay2020

    • Author(s)
      Aye Khin Myo、Nagayasu Eiji、Nyunt Myat Htut、Zaw Ni Ni、Thant Kyaw Zin、Kyaw Myat Phone、Maruyama Haruhiko
    • Journal Title

      BMC Infectious Diseases

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12879-020-05650-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Meningitis patients with Angiostrongylus cantonensis may present without eosinophilia in the cerebrospinal fluid in northern Vietnam2020

    • Author(s)
      Hiraoka Tomoko、Cuong Ngo Chi、Hamaguchi Sugihiro、Kikuchi Mihoko、Katoh Shungo、Anh Le Kim、Anh Nguyen Thi Hien、Anh Dang Duc、Smith Chris、Maruyama Haruhiko、Yoshida Lay-Myint、Cuong Do Duy、Thuy Pham Thanh、Ariyoshi Koya
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 14 Issue: 12 Pages: 0008937-0008937

    • DOI

      10.1371/journal.pntd.0008937

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An outbreak of Paragonimus westermani infection among Cambodian technical intern trainees in Japan, exhibiting various extrapulmonary lesions.2020

    • Author(s)
      Nakagawa Y, Ikematsu Y, Nakanishi T, Ogawa Y, Taen R, Nakashima Y, Okabe H, Yoshida A, Maruyama H
    • Journal Title

      Parasitology International

      Volume: 81 Pages: 102279-102279

    • DOI

      10.1016/j.parint.2020.102279

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a serodiagnosis system for the detection of Toxocara spp. and Ascaris suum infection in chickens.2020

    • Author(s)
      Nguyen YTH, Hayata Y, Sonoda S, Nonaka N, Maruyama H, Yoshida A.
    • Journal Title

      Parasitol Int.

      Volume: 75 Pages: 102022-102022

    • DOI

      10.1016/j.parint.2019.102022

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Human proliferative sparganosis update.2020

    • Author(s)
      Kikuchi T, Maruyama H
    • Journal Title

      Parasitol Int.

      Volume: 75 Pages: 102036-102036

    • DOI

      10.1016/j.parint.2019.102036

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 1.Phylogenetic relationships of Strongyloides species in carnivore hosts.2020

    • Author(s)
      Phoo Pwint Ko, Kazuo Suzuki, Marco Canales-Ramos, Myo Pa Pa Thet Hnin Htwe Aung, Wah Win Htike, Ayako Yoshida, Martin Montes, Kazuhiro Morishita, Eduardo Gotuzzo, Haruhiko Maruyama, Eiji Nagayasu.
    • Journal Title

      Parasitol Int.

      Volume: 78 Pages: 102151-102151

    • DOI

      10.1016/j.parint.2020.102151

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Paragonimus and paragonimiasis in Asia: An update.2019

    • Author(s)
      Yoshida A, Doanh PN, Maruyama H
    • Journal Title

      Acta Trop.

      Volume: 199 Pages: 105074-105074

    • DOI

      10.1016/j.actatropica.2019.105074

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] First molecular identification of Strongyloides vituli in cattle in Japan and insights into the evolutionary history of Strongyloides parasites of ruminants.2019

    • Author(s)
      Ko PP, Sakaguchi K, Yoshida A, Maruyama H, Nonaka N, Nagayasu E.
    • Journal Title

      Parasitol Int.

      Volume: 72 Pages: 101937-101937

    • DOI

      10.1016/j.parint.2019.101937

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 日本における寄生虫症の動向と免疫診断について2019

    • Author(s)
      丸山治彦
    • Organizer
      第30回 日本臨床微生物学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 寄生虫症抗体検査のこれまでとこれから2019

    • Author(s)
      丸山治彦
    • Organizer
      第30回日本臨床寄生虫学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 日本における寄生虫症の動向と免疫診断について2019

    • Author(s)
      丸山治彦
    • Organizer
      第30回日本臨床微生物学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 現在のわが国における寄生蠕虫症の症状について2018

    • Author(s)
      丸山治彦、鴻巣明日香、阿部愛、村瀬一典、菊地泰生、長安英治
    • Organizer
      第29回日本臨床寄生虫学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Paragonimiasis among Asian immigrants in Japan2018

    • Author(s)
      Haruhiko Maruyama, Eiji Nagayasu, Ayako Yoshida
    • Organizer
      14th International Congress of Parasitology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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