Examination of influenza treatment using nude mice
| Project/Area Number |
18K07140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49060:Virology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kiso Maki 東京大学, 医科学研究所, 特任助教 (00624602)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | インフルエンザ / ヌードマウス / インフルエンザウイルス |
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| Outline of Final Research Achievements |
Immunocompromised influenza patients fails to eradicate the viruses. We attempted to eradicate influenza virus from the respiratory organs of nude mice, which is a model of immunocompromised hosts, by using combination therapy of the viral polymerase inhibitor favipiravir and monoclonal antibodies against the HA protein. The triple combination therapy of favipiravir plus anti-stem and anti-RBS mAbs completely stopped virus replication in nude mice, resulting in virus clearance. Triple combination approaches should be considered for the treatment of human immunocompromised patients with severe influenza.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで困難であった、免疫不全モデル動物であるヌードマウスから完全にインフルエンザウイルスを排除することが、ポリメラーゼ阻害剤とHAに対する抗体2種を併用することにより可能となった。このことは、これまで予後不良であったり耐性出現が問題であった免疫不全患者に対するインフルエンザ治療法の１つの選択肢として大きな意義を持つと考えられる。
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Report
(4 results)
Research Products
(2 results)
