Analysis of immunoregulatory mechanisms mediated by paired receptors

• Project/Area Number: 18K07176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAITO Fumiji 金沢医科大学, 医学部, 助教 (20569016)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ペア型レセプター / 抑制化型レセプター / マクロファージ / microglia / 樹状細胞 / レセプター

Outline of Final Research Achievements

Upon infection with pathogens, the immune system is initiated the suppressing system for preventing an excessive immune response along with the activating system for eliminating pathogens. In this study, we examined the functions of paired receptors that has been largely unknown in the brain. We found that the expression of paired inhibitory receptors on brain macrophages was not only increased after LPS administration, but also the expression of an inhibitory cytokine was increased. It is suggested that paired inhibitory receptors were involved in immunosuppression in the brain.

Academic Significance and Societal Importance of the Research Achievements

この研究により、抑制化型レセプターが脳マクロファージに発現し、免疫抑制化に関わっていることが示唆された。さらに詳細な研究を進めることにより、病原体感染時に脳の中における免疫反応の全容が解明され、暴走する免疫システムを押さえ込む治療法の開発に貢献することが期待される。病原体感染（近年では新型コロナウイルスを含む）による脳炎、脳症を発症するケースもあり、学術的意義や社会的意義が十分にあると考える。

Research Products

• [Presentation] Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors (2018)
  • Author(s): Fumiji Saito, Kouyuki Hirayasu, Christian W. Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q. Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii, Hisashi Arase
  • Organizer: The 13th International Symposium of the Institute Network for Biomedical Sciences
  • Int'l Joint Research
• [Book] 臨床免疫・アレルギー科 (2018)
  • Author(s): 齋藤史路、平安恒幸、荒瀬尚
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] 医学のあゆみ (2018)
  • Author(s): 平安恒幸、齋藤史路、荒瀬尚
  • Total Pages: 6
  • Publisher: 医歯薬出版株式会社
• [Book] 実験医学 (2018)
  • Author(s): 齋藤史路、平安恒幸、荒瀬尚
  • Total Pages: 4
  • Publisher: 羊土社