| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
The role of Eed, a mediator of repressive histone modification, in differentiation and maintenance of intraepithelial lymphocytes (IELs) was examined. Loss of Eed in mouse resulted in the trend of increased CD4+ CD8+ IEL. In vitro culture system identified a cell adhesion molecule as an enhancing factor of CD4+ CD8+ IEL differentiation， which was further enhanced by Eed heterozygous deletion. In addition, loss of Eed affected differentiation/survival of CD4+ but not much of CD8+ IELs. These results suggested that the interaction between cell adhesion molecule and epigenetic machinery plays a role in the gut homeostasis.
|
