Neural mechanisms for flexible navigation to adapt a change in an environment

• Project/Area Number: 18K07357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 51020:Cognitive and brain science-related
• Research Institution: Kwansei Gakuin University
• Principal Investigator: SATO Nobuya 関西学院大学, 文学部, 教授 (70465269)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ナビゲーション / 認知地図 / ルート知識 / 脳梁膨大後皮質 / ラット / 脳梁膨大後部皮質 / navigation / route memory / retrosplenial cortex / spatial cognition / rats

Outline of Final Research Achievements

In this study, we required rats to perform a navigation task in which they had to navigate in a maze. The structure of the maze was changed day by day. As the trials proceeded, the distance the rats traveled and the time to reach the goal decreased, suggesting that the rats learned the structure of the maze. We recorded neuronal activity from the retrosplenial cortex of the rats performing the task and found some neurons that showed differential activity depending on the rats' place in the maze. This suggests that the retrosplenial cortex represents place information.

Academic Significance and Societal Importance of the Research Achievements

この研究では，ある地点から別の地点に移動するナビゲーション行動の神経メカニズムを検討した．毎日変化する環境で新たに道順を覚える必要のある状況での実験の結果，脳梁膨大後皮質の神経細胞が場所情報を有していることが示された．海馬と場所の関係はよく知られているが，脳梁膨大後皮質での検討はあまりない．ヒトではこの領域の損傷で，現在地は分かるが目的地にどう行けば分からないという道順障害が生じることが知られている．今回，神経細胞レベルでそのメカニズムの一端を検討することができた．しかし，詳細はまだ明らかとは言えず，今後の研究が望まれる．

Research Products

• [Journal Article] Episodic-like memory of rats as retrospective retrieval of incidentally encoded locations and involvement of the retrosplenial cortex (2021)
  • Author(s): Sato Nobuya
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 2217-2217
  • DOI: 10.1038/s41598-021-81943-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Lesions of the Retrosplenial Cortex on Spatial Tasks in the Rat (2020)
  • Author(s): HAYASHI Tomohiro、SATO Nobuya
  • Journal Title: Japanese Journal of Physiological Psychology and Psychophysiology Volume: 38 Issue: 1 Pages: 34-47
  • DOI: 10.5674/jjppp.2002si
  • NAID: 130008000324
  • ISSN: 0289-2405, 2185-551X
  • Year and Date: 2020-04-30
  • Peer Reviewed
• [Journal Article] Oxytocin in the anterior cingulate cortex is involved in helping behaviour (2020)
  • Author(s): Yamagishi Atsuhito、Lee Joungmin、Sato Nobuya
  • Journal Title: Behavioural Brain Research Volume: 393 Pages: 112790-112790
  • DOI: 10.1016/j.bbr.2020.112790
  • Peer Reviewed
• [Journal Article] Involvement of the retrosplenial cortex in the processing of the temporal aspect of episodic-like memory in rats (2020)
  • Author(s): Hayashi Tomohiro、Oguro Masashi、Sato Nobuya
  • Journal Title: Neuroscience Research Volume: 154 Pages: 52-55
  • DOI: 10.1016/j.neures.2019.05.005
  • Peer Reviewed
• [Journal Article] Oxytocin administration modulates rats’ helping behavior depending on social context (2020)
  • Author(s): Yamagishi Atsuhito、Okada Maya、Masuda Masatoshi、Sato Nobuya
  • Journal Title: Neuroscience Research Volume: 153 Pages: 56-61
  • DOI: 10.1016/j.neures.2019.04.001
  • Peer Reviewed
• [Journal Article] オキシトシンが向社会的行動にもたらす影響 (2019)
  • Author(s): 山岸厚仁・佐藤暢哉.
  • Journal Title: 人文論究 Volume: 69 Pages: 1-17
  • NAID: 120006729741
  • Open Access
• [Journal Article] ラットの条件性抑制における阻止効果の再現 (2019)
  • Author(s): 山岸厚仁・中島定彦・廣野翔太・三島美緑・木本琢海・記田浩明・鹿瀬大稀・松藤未宇・酒井太郎・賈擎宇・橋本侑希美・水江春美・大久保綾香・北野孝太・佐藤暢哉
  • Journal Title: 関西学院大学心理科学研究 Volume: 45 Pages: 9-18
  • NAID: 120006621891
  • Open Access
• [Journal Article] Satiety changes elicited by repeated exposure to the visual appearance of food: Importance of attention and simulating eating action (2018)
  • Author(s): Kazuya Inoue, Keiko Otake, Nobuya Sato
  • Journal Title: Journal of Health Psychology Research Volume: 31 Issue: 1 Pages: 9-19
  • DOI: 10.11560/jhpr.171031094
  • NAID: 130007429121
  • ISSN: 2189-8790, 2189-8804
  • Year and Date: 2018-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Preferential representation of past outcome information and future choice behavior by putative inhibitory interneurons rather than putative pyramidal neurons in the primate dorsal anterior cingulate cortex (2018)
  • Author(s): Takashi Kawai, Hiroshi Yamada, Nobuya Sato, Masahiko Takada, Masayuki Matsumoto
  • Journal Title: Cerebral Cortex Volume: 印刷中 Issue: 6 Pages: 2339-2352
  • DOI: 10.1093/cercor/bhy103
  • Peer Reviewed
• [Journal Article] To take or not to take the shortcut: Flexible spatial behaviour of rats based on cognitive map in a lattice maze (2018)
  • Author(s): Sato Nobuya、Fujishita Chihiro、Yamagishi Atsuhito
  • Journal Title: Behavioural Processes Volume: 151 Pages: 39-43
  • DOI: 10.1016/j.beproc.2018.03.010
  • Peer Reviewed
• [Journal Article] The mere exposure effect for visual image (2017)
  • Author(s): Inoue Kazuya、Yagi Yoshihiko、Sato Nobuya
  • Journal Title: Memory & Cognition Volume: 46 Issue: 2 Pages: 181-190
  • DOI: 10.3758/s13421-017-0756-6
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Do rats show the behavior to reduce uncertainty? (2020)
  • Author(s): 高橋良幸・佐藤暢哉
  • Organizer: 日本動物心理学会第80回大会(オンライン開催).
• [Presentation] Examination of the spatial ability in rats using a complex maze. (2020)
  • Author(s): 林朋広・佐藤暢哉
  • Organizer: 日本動物心理学会第80回大会(オンライン開催).
• [Presentation] Sex differences in helping behavior in prairie voles.. (2020)
  • Author(s): 北野孝太・佐藤暢哉
  • Organizer: 日本動物心理学会第80回大会(オンライン開催)
• [Presentation] Wild-derived heterogeneous stock (WHS) mice demonstrate helping behavior toward distressed conspecifics. (2020)
  • Author(s): 山岸厚仁・小出剛・佐藤暢哉
  • Organizer: 日本動物心理学会第80回大会(オンライン開催)
• [Presentation] Oxytocin receptor knockout prairie voles display deficits in helping behavior (2020)
  • Author(s): Kitano, K., Yamagishi, A., Nishimori, K., & Sato, N.
  • Organizer: The 43th Anuual Meeting of the Japan Neuroscience Society
• [Presentation] 生理反応に対する隠蔽意図がCITに与える影響 (2019)
  • Author(s): 小松丈洋・幸地あゆみ・道野栞・佐藤暢哉
  • Organizer: 日本基礎心理学会第38回大会
• [Presentation] 同時弁別課題時における接近・回避行動の学習過程の検討 (2019)
  • Author(s): 道野栞・小松丈洋・佐藤暢哉
  • Organizer: 日本基礎心理学会第38回大会
• [Presentation] he effect of helped/non-helped experience on helping behavior in rats (2019)
  • Author(s): 北野孝太・山岸厚仁・佐藤暢哉
  • Organizer: 日本動物心理学会第79回大会
• [Presentation] Discrmination of the shape of looped runways in rats (2019)
  • Author(s): 佐藤朱夏・佐藤暢哉
  • Organizer: 日本動物心理学会第79回大会
• [Presentation] An attempt to clarify spatial abilities of rats in a three-dimensional maze (2019)
  • Author(s): 林朋広・池川真奈・佐藤暢哉
  • Organizer: 日本動物心理学会第79回大会
• [Presentation] Do rats keep on obtaining the redundant information? (2019)
  • Author(s): 高橋良幸・佐藤暢哉
  • Organizer: 日本動物心理学会第79回大会
• [Presentation] Rats help conspecifics even when they receive aversive stimuli to do it (2019)
  • Author(s): 山岸厚仁・内田有咲・佐藤暢哉
  • Organizer: 日本動物心理学会第79回大会
• [Presentation] nvolvement of anterior cingulate cortex in helping behavior in rats (2019)
  • Author(s): Sato, N., Yamagishi, A., Inutsuka, A., & Onaka, T.
  • Organizer: The 42th Anuual Meeting of the Japan Neuroscience Society
• [Presentation] 回想的映像に対する事象関連脳電位 (2019)
  • Author(s): 佐藤暢哉・沖悠司・道野栞
  • Organizer: 第37回日本生理心理学会大会
• [Presentation] 物体位置に関する視覚・言語情報の呈示が空間的視点取得に及ぼす影響 (2018)
  • Author(s): 道野栞・佐藤暢哉
  • Organizer: 日本基礎心理学会第37回大会
• [Presentation] Behavior of a demonstrator affects helping behavior of an observer in rats. (2018)
  • Author(s): Yamagishi, A., & Sato, N.
  • Organizer: 日本動物心理学会第78回大会
• [Presentation] The effect of prior visual exploration on the following in situ exploration in rats. (2018)
  • Author(s): Sato, N., Zhu, Q., & Takahashi, Y.
  • Organizer: 日本動物心理学会第78回大会
• [Presentation] Discrimination of shape of mazes in rats. (2018)
  • Author(s): Sato, A., & Sato, N.
  • Organizer: 日本動物心理学会第78回大会
• [Presentation] 多視点観察時に生じる空間記憶統合の阻害 (2018)
  • Author(s): 道野栞・佐藤暢哉
  • Organizer: 日本心理学会第82回大会.
• [Presentation] Effect of lesions of the retrosplenial cortex on tracing a learned route that includes a small change in spatial structure. (2018)
  • Author(s): Hayashi, T., & Sato, N.
  • Organizer: Annual meeting of Society for Neuroscience
• [Presentation] Activation of oxytocin receptor-expressing neurons in anterior cingulate cortex during helping behavior in rats. (2018)
  • Author(s): Yamagishi, A., & Sato, N.
  • Organizer: Annual meeting of Society for Neuroscience
• [Book] 有斐閣 現代心理学辞典 (2021)
  • Author(s): 子安 増生、丹野 義彦、箱田 裕司
  • Total Pages: 1002
  • Publisher: 有斐閣
  • ISBN: 9784641002661
• [Book] 神経・生理心理学 (2019)
  • Author(s): 太田 信夫、片山 順一
  • Total Pages: 176
  • Publisher: 北大路書房
  • ISBN: 9784762830686
• [Book] 基礎心理学実験法ハンドブック (2018)
  • Author(s): 日本基礎心理学会
  • Total Pages: 608
  • Publisher: 朝倉書店
  • ISBN: 9784254520231
• [Remarks] 関西学院大学心理科学研究室
  • URL: http://psysci.kwansei.ac.jp/
• [Remarks] 佐藤暢哉研究室
  • URL: https://sites.google.com/site/nsatolab/home
• [Remarks] 関西学院大学文学部総合心理科学科佐藤暢哉研究室
  • URL: https://sites.google.com/site/nsatolab/