| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The aim of this study was to clarify the role of LR11, an LDL receptor super-family member, on the browning phenotype transition of adipocytes. The cell-biological study using 2D-cultured brown adipocytes and 3D-cultured beige adipocytes suggested that LR11 is involved in the trans-differentiation mechanism among the white, brown and beige phenotypes of the cultured adipocytes. The human sample studies indicated that circulating soluble LR11 levels are increased in diseases with advanced atherosclerosis. LR11 is expected to be an examination marker for atherosclerosis in association with the disturbed regulation of trans-differentiation in adipocytes.
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