Establishment of clinical significance of serum hepatic lipase assay and its clinical application
| Project/Area Number |
18K07484
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Toho University (2019-2020)
Kanazawa Medical University (2018) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中嶋 克行 女子栄養大学, 付置研究所, 客員教授 (10444051)
多田 隼人 金沢大学, 附属病院, 助教 (90623653)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肝性リパーゼ / SYNTAXスコア / 冠動脈疾患 / 動脈硬化症 / 甲状腺ホルモン / リポ蛋白リパーゼ / 血管内皮リパーゼ |
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| Outline of Final Research Achievements |
Hepatic lipase (HL) is a lipid metabolizing enzyme that hydrolyzes TG in remnants and HDL. It is not clear whether it is pro- or anti-atherosclerotic. We investigated the relationship between HL protein levels and the SYNTAX score, which quantitatively assesses the severity of coronary artery disease. The subjects were 100 patients (age 70.7±11.5 years, LDL-C 101±32 mg/dl, 87 males) who underwent coronary angiography, and HL protein levels were measured by a method developed by us. The correlation coefficients between SYNTAX score and serum HL and post-heparin plasma HL protein levels were r = 0.214 (ns) and r = -0.178 (ns), respectively. These results indicate that there is no significant correlation between hepatic lipase protein level and SYNTAX score.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の検討からは冠動脈疾患重症度を定量的に評価するSYNTAXスコアと肝性リパーゼとの明らかな相関はみられなかった。一方で対象が100例と少なかったことも影響すると考える。肝性リパーゼを簡便に測定できる方法が確立しているので、今後は多数の対象で検討し、男女差、糖尿病の有無、腎臓病の有無などで層別化し検討を進めていく意義のあるテーマと考えている。
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] An automated method for measuring lipoprotein lipase and hepatic triglyceride lipase activities in post-heparin plasma.2018
Author(s)
Nakajima K, Machida T, Imamura S, Kawase D, Miyashita K, Fukamachi I, Maeda M, Muraba Y, Koga T, Kobayashi J, Kimura T, Nakajima K, Murakami M.
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Journal Title
Clin Chim Acta.
Volume: 487
Pages: 54-59
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] GPIHBP1自己抗体陽性高カイロミクロン血症のCM粒子サイズについての検討2020
Author(s)
長澤拓海, 中嶋克行, 宮下かずや, 深町 勇, 多田隼人, 野原 淳, 川尻剛照, 小林淳二, 中嶋清美, 常川勝彦, 木村孝穂, 村上正巳
Organizer
第52回日本動脈硬化学会総会・学術集会
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