A nationwide survey in Japan focusing on dementia prevention: the effect of lithium in drinking water
| Project/Area Number |
18K07605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
寺尾 岳 大分大学, 医学部, 教授 (80217413)
横山 和仁 順天堂大学, 医学部, 客員教授 (00158370)
松川 岳久 順天堂大学, 医学部, 助教 (60453586)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リチウム / 認知症 / メンタルヘルス / 水道水 / 水資源 |
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| Outline of Final Research Achievements |
Recent clinical studies suggest that lithium has the effect of preventing cognitive decline and reducing the risk of developing dementia. The purpose of this study was to test the hypothesis that trace amounts of lithium in tap water and blood could prevent dementia. Although the results were not in accordance with this hypothesis, there was a significant negative correlation between blood lithium levels and verbal memory in men. It was suggested that small amounts of lithium may help prevent cognitive impairment.
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| Academic Significance and Societal Importance of the Research Achievements |
治療濃度のリチウムが認知機能低下予防や認知症発症リスクを低下させる効果を有することが近年の研究で示唆されているが、微量なリチウムと認知症および認知機能に関する研究報告はいまだに少なく、一致した見解が得られていない。今回の結果は「水道水や血液に含まれる微量なリチウムが認知症を予防する」という当初の仮説を支持するものではなかったが、中高年者の認知機能に対して負の相関を示した。将来的に微量なリチウムにより認知障害が予防できる可能性を示唆したことで社会的意義は高い。
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Report
(5 results)
Research Products
(5 results)
