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Development of quality assurance of high dose rate brachytherapy using 3D polymer gel dosimeter

Research Project

Project/Area Number 18K07639
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Takenaka Tadashi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (80626771)

Co-Investigator(Kenkyū-buntansha) 山崎 秀哉  京都府立医科大学, 医学(系)研究科(研究院), 教授 (50301263)
鈴木 弦  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80279182)
増井 浩二  京都府立医科大学, 医学(系)研究科(研究院), 助教 (20783830)
吉田 謙  関西医科大学, 医学部, 准教授 (10463291)
秋山 広徳  大阪歯科大学, 歯学部, 准教授 (20448111)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords高線量率密封小線源治療 / HDR / 3次元ポリマーゲル線量計 / 品質保証 / 組織内照射 / 高線量率小線源治療 / 連続的な線量分布を直接測定 / Ir192 / 酸化 / アプリケータ偏移 / 3次元ポリマーゲル線量計 / 高線量率密封小線源 / 混濁 / 不均質補正 / 放射線治療 / RALS / 小線源治療 / 品質管理 / 医学物理
Outline of Final Research Achievements

A new phantom and dedicated glass applicator were developed using a glass container with high oxygen permeability. Irradiation was performed by inserting a 4fr round needle resin applicator into the developed glass applicator. Analysis was performed using dedicated software. In conclusion, the use of a highly oxygen-permeable glass phantom and glass applicator reduced the oxidation that is a drawback of the 3D polymer gel dosimeter. Furthermore, the use of dedicated software made it possible to analyze the irradiation plan and measured dose distribution. This study suggests that the 3D polymer gel dosimeter can be used for quality assurance in high-precision brachytherapy.

Academic Significance and Societal Importance of the Research Achievements

研究成果の学術的意義や社会的意義として3次元ポリマーゲル線量計の欠点でもある酸化に対して耐酸素透過性のある材質の一つであるガラス素材をファントム容器に使用することで、酸化を減少させ3次元ポリマーゲル線量計の取り扱いが簡単になった。また専用解析ソフトを使用することでガンマ解析も可能となり3次元ポリマーゲル線量計を高精度小線源治療の品質保証に利用できることが示唆されたことなどが挙げられる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2023 2022 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Initial tumor volume as an important predictor for indication of intra-cavitary brachytherapy, intra-cavitary/interstitial brachytherapy, and multi-catheter sole interstitial brachytherapy in cervical cancer patients treated with chemoradiotherapy2023

    • Author(s)
      Takenaka Tadashi、Yamazaki Hideya、Suzuki Gen、Masui Koji、Shimizu Daisuke、Kotsuma Tadayuki、Tanaka Eiichi、Yoshida Ken、Yamada Kei
    • Journal Title

      Journal of Contemporary Brachytherapy

      Volume: 15 Issue: 3 Pages: 191-197

    • DOI

      10.5114/jcb.2023.128895

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 画像誘導小線源治療からみえてきた放射線治療計画への注意点2022

    • Author(s)
      武中 正
    • Journal Title

      日本放射線技術学会誌 教育講座

      Volume: 78 Pages: 1217-1223

    • Related Report
      2022 Research-status Report
  • [Presentation] 3次元ポリマーゲル線量計を利用した高線量率組織内照射用のファントムの開発2022

    • Author(s)
      武中 正
    • Organizer
      第11回 3次元(3D)ゲル線量計研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] 高線量率RALS線源用3次元ゲル線量計校正ファントムの開発ー経過報告ー2020

    • Author(s)
      武中 正
    • Organizer
      医局内カンファレンス
    • Related Report
      2020 Research-status Report
  • [Presentation] 高線量率RALS線源用3次元ゲル線量計校正ファントムの開発2019

    • Author(s)
      武中 正
    • Organizer
      第8回 3次元ゲル線量計研究会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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