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Establishment of an MRI-based screening technique for early-stage hepatocellular carcinoma in patients with advanced liver disease

Research Project

Project/Area Number 18K07669
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKanazawa University

Principal Investigator

Kobayashi Satoshi  金沢大学, 保健学系, 教授 (30313638)

Co-Investigator(Kenkyū-buntansha) 南 哲弥  金沢医科大学, 医学部, 教授 (60436813)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肝細胞癌 / MRI / ガドキセト酸ナトリウム / TSM / 中枢神経系 / Gd-EOB-DTPA / 早期肝細胞癌 / 進行肝臓病 / ラット / トランスポーター
Outline of Final Research Achievements

One of the disadvantages of EOB contrast-enhanced MRI in screening for hepatocellular carcinoma is poor arterial phase imaging, called transient severe motion (TSM). We have shown that transient severe motion of the abdominal wall plays a major role in the development of TSM. We also examined the appearance of TSMs in rats treated with EOB in animal experiments, and found that TSMs caused by EOB administration are most likely caused by the direct effect of EOB on the central nervous system. In order to predict the early deterioration of image quality in cases of reduced hepatic reserve, which is a problem in hepatocellular phase imaging, we clarified the details of temporal changes in EOB uptake into hepatocytes using clinical cases.

Academic Significance and Societal Importance of the Research Achievements

Gd-EOB-DTPA (EOB)は、これまで診断が困難であった早期肝癌の有無を明瞭に示すことができるため、肝癌診療に貢献し、肝癌死亡率の減少に繋げることが期待されている画期的なMRI造影剤である。しかし、一部の患者ではTransient severe motion (TSM)と呼ばれる動脈相画像の不良が生じ、肝細胞癌の検出能が著しく低下する。今回の検討によりTSMの発生には一過性の腹壁の運動が大きく関与していること、TSM発生はEOBが中枢神経系に直接作用して生じる可能性が高いことを明らかにした。これらの発見はTSMの頻度の減少、肝細胞癌の検出能の向上につながる有意義な研究と考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2021 2020 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Prediction of Sufficient Liver Enhancement on the Gadoxetate Disodium-enhanced Hepatobiliary Phase Imaging Using Transitional Phase Images and Albumin–bilirubin Grade2021

    • Author(s)
      Takatsu Y, Nakamura M, Kobayashi S, Miyati T.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 2 Pages: 152-159

    • DOI

      10.2463/mrms.mp.2020-0050

    • NAID

      130008046879

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraarterial and intravenous contrast enhanced CT and MR imaging of multi-step hepatocarcinogenesis defining the early stage of hepatocellular carcinoma development.2020

    • Author(s)
      Kobayashi S, Kozaka K, Gabata T, Matsui O, Minami T.
    • Journal Title

      Hepatoma Res.

      Volume: 6 Pages: 36-36

    • DOI

      10.20517/2394-5079.2020.24

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the degree of abdominal wall movement and the image quality of contrast-enhanced MRI: semi-quantitative study especially focused on the occurrence of transient severe motion artifact.2019

    • Author(s)
      Ikeno H, Kobayashi S, Kozaka K, Ogi T, Inoue D, Yoneda N, Yoshida K, Ohno N, Gabata T, Kitao A.
    • Journal Title

      Jpn J Radiol.

      Volume: 38 Issue: 2 Pages: 165-177

    • DOI

      10.1007/s11604-019-00896-2

    • NAID

      210000160943

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of renal oxygen saturation using photoacoustic imaging for the early prediction of chronic renal function in a model of ischemia-induced acute kidney injury2018

    • Author(s)
      Okumura Kenichiro、Matsumoto Junichi、Iwata Yasunori、Yoshida Kotaro、Yoneda Norihide、Ogi Takahiro、Kitao Azusa、Kozaka Kazuto、Koda Wataru、Kobayashi Satoshi、Inoue Dai、Sakai Norihiko、Furuichi Kengo、Wada Takashi、Gabata Toshifumi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: e0206461-e0206461

    • DOI

      10.1371/journal.pone.0206461

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Signal intensity pattern of hepatic pseudolesion observed in the third inflow area on hepatobiliary phase of Gd-EOB-DTPA enhanced MRI2020

    • Author(s)
      S. Kobayashi, K. Kozaka, A. Kitao, D. Inoue, N. Yoneda, K. Yoshida, W. Koda, T. Gabata.
    • Organizer
      ESGAR 2020 Virtual Meeting,
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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