Cardiac presynaptic sympathetic nervous function evaluated by cardiac PET in patients with chronotropic incompetence
| Project/Area Number |
18K07686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Nagoya City University |
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Principal Investigator |
Goto Toshihiko 名古屋市立大学, 医薬学総合研究院(医学), 講師 (50596905)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Discontinued (Fiscal Year 2022)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 変時性不全 / PET / 心臓交感神経 / 心臓交感神経節前機能 / hydroxyephedrine / 交感神経 / 心臓交感神経β受容体 |
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| Outline of Final Research Achievements |
Cardiac presynapse sympathetic nervous function was investigated using cardiac positron emission tomography (PET), with carbon-11 hydroxyephedrine (C-11 HED) in patients with chronotropic incompetence (CI) without heart failure. Presynapse sympathetic nervous function was quantitatively evaluated using HED myocardial retention rate (HED-RI) on HED PET.
The HED-RI was significantly higher in patients with in patients with CI (n = 9) than in healthy subjects (n=6) (13.8 ± 3.0 vs. 8.5 ± 3.9%/min, p = 0.01). This indicates that in patients with CI, cardiac sympathetic nerve terminals cannot adequately release catecholamines, which may partly be involved in the mechanism of CI.
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| Academic Significance and Societal Importance of the Research Achievements |
変時性不全におけるpost-synapse機能の障害はすでに確立している。これのみであればβ受容体への介入手段としてβ遮断薬が考慮される。本研究においては、これまで検討されてこなかったpre-synapse機能を評価の対象とした。その結果、変時性不全においては従来指摘されてきたpose-synapse機能の障害のみならず、pre-synapse機能においても障害が存在することが証明された。このため、変時性不全においては、pre-synapse機能の障害を補う必要があることが明らかになった。本研究の結果は、変時性不全に対する適切な介入方法の創造に寄与できる。
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Report
(5 results)
Research Products
(1 results)
