Cardiac presynaptic sympathetic nervous function evaluated by cardiac PET in patients with chronotropic incompetence

• Project/Area Number: 18K07686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Nagoya City University
• Principal Investigator: Goto Toshihiko 名古屋市立大学, 医薬学総合研究院(医学), 講師 (50596905)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Discontinued (Fiscal Year 2022)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 変時性不全 / PET / 心臓交感神経 / 心臓交感神経節前機能 / hydroxyephedrine / 交感神経 / 心臓交感神経β受容体

Outline of Final Research Achievements

Cardiac presynapse sympathetic nervous function was investigated using cardiac positron emission tomography (PET), with carbon-11 hydroxyephedrine (C-11 HED) in patients with chronotropic incompetence (CI) without heart failure. Presynapse sympathetic nervous function was quantitatively evaluated using HED myocardial retention rate (HED-RI) on HED PET.
The HED-RI was significantly higher in patients with in patients with CI (n = 9) than in healthy subjects (n=6) (13.8 ± 3.0 vs. 8.5 ± 3.9%/min, p = 0.01). This indicates that in patients with CI, cardiac sympathetic nerve terminals cannot adequately release catecholamines, which may partly be involved in the mechanism of CI.

Academic Significance and Societal Importance of the Research Achievements

変時性不全におけるpost-synapse機能の障害はすでに確立している。これのみであればβ受容体への介入手段としてβ遮断薬が考慮される。本研究においては、これまで検討されてこなかったpre-synapse機能を評価の対象とした。その結果、変時性不全においては従来指摘されてきたpose-synapse機能の障害のみならず、pre-synapse機能においても障害が存在することが証明された。このため、変時性不全においては、pre-synapse機能の障害を補う必要があることが明らかになった。本研究の結果は、変時性不全に対する適切な介入方法の創造に寄与できる。

Research Products

• [Presentation] Cardiac Presynaptic Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence (2022)
  • Author(s): Goto T, Kikuchi S, Mori K, Nakayama T, Wakami K, Fukuta H, Matsui K, Narita H, Iida A, Seo Y.
  • Organizer: 第86回日本循環器学会学術集会