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Dynamic analysis of fMRI data: technical development and clinical application

Research Project

Project/Area Number 18K07707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionThe University of Tokyo

Principal Investigator

Amemiya Shiori  東京大学, 医学部附属病院, 講師 (90631135)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsfMRI / neural network / perfusion / neural networks / neurovascular coupling / 灌流画像法 / 自発性神経活動 / network / 脳 / 信号解析
Outline of Final Research Achievements

To investigate the origin of the global signals and the local resting-state network signals measured in humans using fMRI and their time lag, we examined the spatiotemporal patterns of the global signals acquired in resting-state as well as under wide-field visual stimulation. The correlation between the extracranial arterial signals and the global signals was also examined. The results showed that resting-state fMRI BOLD signal time lag represents differences in local hemodynamic response functions, rather than time differences derived from stimuli/triggers, whether neurogenic or not, and that the global signals likely reflect physiological changes in blood flow and blood pressure that are almost synchronized in a wide range of intracranial and extracranial regions.

Academic Significance and Societal Importance of the Research Achievements

広域かつ高空間分解能のin vivo神経活動計測を可能とする安静時fMRIは、巨視的神経回路の情報動態解析から、脳高次機能の生理・病理の理解を目指す上で重要な情報をもたらことが期待されている。しかしながらfMRIは神経血管連動を介した間接的計測であり、特に自発性神経活動をターゲットとする安静時fMRIでは信号成分の由来の確認なしには正確な解釈が困難になる。本研究では安静時fMRI信号の時間差解析から広汎性信号成分、局所ネットワーク成分の由来の確認を進めた。結果は非神経性由来の信号分離による、より正確な神経活動計測法開発のための基礎となるものと考えられる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Reliability and Sensitivity to Alterered Hemodynamics Measured with Resting-state fMRI Metrics: Comparison with 123I-IMP SPECT.2022

    • Author(s)
      Shiori Amemiya, Hidemasa Takao, Yusuke Watanabe, Satoru Miyawaki, Satoshi Koizumi, Nobuhito Saito, Osamu Abe
    • Journal Title

      Neuroimage

      Volume: 27 Pages: 119654-119654

    • DOI

      10.1016/j.neuroimage.2022.119654

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arterial Transit Time-Based Multidelay Combination Strategy Improves Arterial Spin Labeling Cerebral Blood Flow Measurement Accuracy in Severe Steno-Occlusive Diseases2022

    • Author(s)
      Amemiya S, Watanabe Y, Takei N, Ueyama T, Miyawaki S, Koizumi S, Kato S, Takao H, Abe O, Saito N.
    • Journal Title

      J Magn Reson Imaging

      Volume: 55 Issue: 1 Pages: 178-187

    • DOI

      10.1002/jmri.27823

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accelerated Two-Point Dixon MR Angiography Improves Diagnostic Performance for Cervical Artery Diseases.2022

    • Author(s)
      Amemiya S, Takei N, Ueyama T, Fujii K, Takao H, Yasaka K, Watanabe Y, Kamiya K, Abe O.
    • Journal Title

      J Magn Reson Imaging

      Volume: NA Issue: 3 Pages: 929-941

    • DOI

      10.1002/jmri.28122

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reliability and Sensitivity to Longitudinal CBF Changes in Steno-Occlusive Diseases: ASL Versus 123 I-IMP-SPECT.2021

    • Author(s)
      Amemiya S, Takao H, Watanabe Y, Takei N, Ueyama T, Kato S, Miyawaki S, Koizumi S, Abe O, Saito N.
    • Journal Title

      J Magn Reson Imaging

      Volume: NA Issue: 6 Pages: 1723-1732

    • DOI

      10.1002/jmri.27996

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI2020

    • Author(s)
      Amemiya Shiori、Takao Hidemasa、Abe Osamu
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14

    • DOI

      10.3389/fnins.2020.596084

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accelerated acquisition of carotid MR angiography using 3D gradient-echo imaging with two-point Dixon2020

    • Author(s)
      Irie Ryusuke、Amemiya Shiori、Ueyama Tsuyoshi、Suzuki Yuichi、Kamiya Kouhei、Takao Hidemasa、Mori Harushi、Abe Osamu
    • Journal Title

      Neuroradiology

      Volume: 62 Issue: 10 Pages: 1345-1349

    • DOI

      10.1007/s00234-020-02452-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Global vs. Network-Specific Regulations as the Source of Intrinsic Coactivations in Resting-State Networks2019

    • Author(s)
      Shiori Amemiya*, Hidemasa Takao and Osamu Abe
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 13 Pages: 65-65

    • DOI

      10.3389/fnsys.2019.00065

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integrated multi-echo denoising strategy improves identification of inherent language laterality2018

    • Author(s)
      Shoiri Amemiya, Hiroshi Yamashita, Hidemasa Takao, Osamu Abe
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: 81 Issue: 5 Pages: 3262-3271

    • DOI

      10.1002/mrm.27620

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Accelerated Two-Point Dixon MR Angiography Improves Diagnostic Performance for Cervical Artery Diseases2023

    • Author(s)
      Shiori Amemiya
    • Organizer
      ECR 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multi-delay Arterial Spin Labeling Perfusion MRI: 虚血性脳疾患での検証2022

    • Author(s)
      雨宮史織
    • Organizer
      第33回 臨床MR脳機能研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Accelerated Two-Point Dixon MRAngiography Improves Diagnostic Performance for Cervical Artery Diseases2022

    • Author(s)
      雨宮史織
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Reliability and Sensitivity to Longitudinal CBF Changes in Steno-Occlusive D iseases: ASL Versus 123 I-IMP-SPECT2022

    • Author(s)
      雨宮史織
    • Organizer
      第58回日本医学放射線学会秋季臨床大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Arterial transit time-based Combo strategy improves arterial spin labeling c erebral blood flow measurement accuracy in severe steno-occlusive diseases2021

    • Author(s)
      雨宮 史織
    • Organizer
      第57回日本医学放射線学会秋季臨床大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI2021

    • Author(s)
      Shiori Amemiya
    • Organizer
      ECR 2021 (European Congress of Radiology)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Integrated multi-echo denoising strategy improves language mapping with resting-state fMRI2019

    • Author(s)
      Shoiori Amemiya
    • Organizer
      ECR 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合的マルチエコー安静時fMRI 解析法は内因性神経活動の半球優位性評価を改善する2018

    • Author(s)
      雨宮 史織
    • Organizer
      第54回日本医学放射線学会秋季臨床大会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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