Diagnosis of extra nodal extension based on multimodality imaging and machine learning in patients with head and neck cancer.

• Project/Area Number: 18K07758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kumamoto University
• Principal Investigator: Toya Ryo 熊本大学, 大学院生命科学研究部(医), 准教授 (60452893)
• Co-Investigator(Kenkyū-buntansha): 甲斐 祐大 熊本大学, 病院, 診療放射線技師 (60816239)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 放射線治療 / 頭頸部腫瘍 / リンパ節転移 / 節外浸潤 / 機械学習

Outline of Final Research Achievements

We evaluated the diagnostic value of FDG-PET/CT for the identification of ENE in HNSCC patients. We recorded SUVmax and compared the results with pathologic findings of 94 HNSCC patients. An ROC curve analysis for SUVmax showed an AUC value of 0.913. A SUVmax cut-off of 3.0 achieved diagnostic performance for identifying ENE with sensitivity, specificity, and accuracy of 81.1%, 94.3% and 93.1%, respectively. We found that SUVmax cut-off of 3.0 provides appropriate diagnostic value in identifying ENE. Additionally, we evaluated the influence of spatial resolution on SUV based on phantom study. The images were reconstructed using three isotropic voxel sizes. Differences in the SUVmax were significant between the three voxel sizes (p<0.001). We found that spatial resolution influences on SUV, therefore, SUVmax cut-off should be defined based on spatial resolution.

Academic Significance and Societal Importance of the Research Achievements

頭頸部腫瘍において、節外浸潤は予後不良因子であるとされ、その有無は治療方針決定に大きな影響を及ぼす。放射線治療の治療計画においても臨床標的体積の決定に必要な情報である。このため節外浸潤の診断は臨床的に非常に重要であるが、これまで診断能が高い方法は報告されていなかった。本研究によって節外浸潤の診断が非常に高い精度をもって可能になることが示唆された。また、近年導入が進んでいる高分解能PET/CT装置の導入における問題点についても新たな知見が得られ、今後更なる研究の発展が期待できるものと考えられる。

Research Products

• [Journal Article] Impact of four-dimensional cone-beam computed tomography on target localization for gastric mucosa-associated lymphoid tissue lymphoma radiotherapy: reducing planning target volume (2021)
  • Author(s): Shimohigashi Y, Toya R, Saito T, Kono Y, Doi Y, Fukugawa Y, Watakabe T, Matsumoto T, Kai Y, Maruyama M, Oya N.
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 14-14
  • DOI: 10.1186/s13014-020-01734-w
  • Peer Reviewed / Open Access
• [Journal Article] High Spatial Resolution Digital Positron Emission Tomography Images With Dedicated Source-to-background Algorithm for Radiotherapy Planning (2020)
  • Author(s): WATAKABE TAKAHIRO、TOYA RYO、SAITO TETSUO、MATSUYAMA TOMOHIKO、SHIRAISHI SHINYA、KAI YUDAI、SHIMOHIGASHI YOSHINOBU、OYA NATSUO
  • Journal Title: Anticancer Research Volume: 40 Issue: 5 Pages: 2567-2572
  • DOI: 10.21873/anticanres.14227
  • Peer Reviewed / Open Access
• [Journal Article] Stereotactic Body Radiotherapy Based on 99mTc-GSA SPECT Image-guided Inverse Planning for Hepatocellular Carcinoma (2020)
  • Author(s): KAI YUDAI、TOYA RYO、SAITO TETSUO、MATSUYAMA TOMOHIKO、FUKUGAWA YOSHIYUKI、SHIRAISHI SHINYA、SHIMOHIGASHI YOSHINOBU、OYA NATSUO
  • Journal Title: In Vivo Volume: 34 Issue: 6 Pages: 3583-3588
  • DOI: 10.21873/invivo.12202
  • Peer Reviewed / Open Access
• [Journal Article] Semi-automated prediction approach of target shifts using machine learning with anatomical features between planning and pretreatment CT images in prostate radiotherapy (2020)
  • Author(s): Kai, Y. Arimura, H. Ninomiya, K. Saito, T. Shimohigashi, Y. Kuraoka, A. Maruyama, M. Toya, R. Oya, N.
  • Journal Title: J Radiat Res Volume: 61 Issue: 2 Pages: 285-297
  • DOI: 10.1093/jrr/rrz105
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic Value of FDG-PET/CT for the Identification of Extranodal Extension in Patients With Head and Neck Squamous Cell Carcinoma (2020)
  • Author(s): Toya, R. Saito, T. Matsuyama, T. Kai, Y. Shiraishi, S. Murakami, D. Yoshida, R. Watakabe, T. Sakamoto, F. Tsuda, N. Arimura, H. Orita, Y. Nakayama, H. Oya, N.
  • Journal Title: Anticancer Res Volume: 40 Issue: 4 Pages: 2073-2077
  • DOI: 10.21873/anticanres.14165
  • Peer Reviewed / Open Access
• [Journal Article] Image quality evaluation of in-treatment four-dimensional cone-beam computed tomography in volumetric-modulated arc therapy for stereotactic body radiation therapy (2019)
  • Author(s): Shimohigashi, Y. Doi, Y. Kouno, Y. Yotsuji, Y. Maruyama, M. Kai, Y. Toya, R.
  • Journal Title: Phys Med Volume: 68 Pages: 10-16
  • DOI: 10.1016/j.ejmp.2019.11.003
  • Peer Reviewed
• [Journal Article] Comparison of rigid and deformable image registration for nasopharyngeal carcinoma radiotherapy planning with diagnostic position PET/CT (2019)
  • Author(s): Kai, Y. Arimura, H. Toya, R. Saito, T. Matsuyama, T. Fukugawa, Y. Shiraishi, S. Shimohigashi, Y. Maruyama, M. Oya, N.
  • Journal Title: Jpn J Radiol Volume: 38 Issue: 3 Pages: 256-264
  • DOI: 10.1007/s11604-019-00911-6
  • NAID: 210000187152
  • Peer Reviewed
• [Journal Article] Impact of (99m)Tc-GSA SPECT Image-Guided Inverse Planning on Dose-Function Histogram Parameters for Stereotactic Body Radiation Therapy Planning for Patients With Hepatocellular Carcinoma: A Dosimetric Comparison Study (2019)
  • Author(s): Toya, R. Saito, T. Kai, Y. Shiraishi, S. Matsuyama, T. Watakabe, T. Sakamoto, F. Tsuda, N. Shimohigashi, Y. Yamashita, Y. Oya, N.
  • Journal Title: Dose Response Volume: 17 Issue: 1 Pages: 0-0
  • DOI: 10.1177/1559325819832149
  • Peer Reviewed / Open Access
• [Journal Article] Impact of hybrid FDG-PET/CT on gross tumor volume definition of cervical esophageal cancer: reducing interobserver variation (2019)
  • Author(s): Toya R, Matsuyama T, Saito T, Imuta M, Shiraishi S, Fukugawa Y, Iyama A, Watakabe T, Sakamoto F, Tsuda N, Shimohigashi Y, Kai Y, Murakami R, Yamashita Y, Oya N.
  • Journal Title: J Radiat Res Volume: 60 (3) Issue: 3 Pages: 348-352
  • DOI: 10.1093/jrr/rrz004
  • Peer Reviewed / Open Access
• [Journal Article] Target volume and motion position evaluation of four-dimensional cone-beam CT: comparison with 4D-CT using dynamic thorax phantom (2019)
  • Author(s): Yasuhiro Doi, Yoshinobu Shimohigashi, Yohei Yotsuji, Masato Maruyama, Yudai Kai, Ryo Toya
  • Journal Title: Biomedical Physics & Engineering Express Volume: 5 Issue: 3 Pages: 035016-035016
  • DOI: 10.1088/2057-1976/ab1054
  • Peer Reviewed
• [Presentation] Dose-function histogram evaluation using 99mTc-GSA SPECT/CT images for SBRT planning for HCC (2018)
  • Author(s): R. Toya, T. Saito, S. Shiraishi, Y. Kai, R. Murakami, T. Matsuyama, T. Watakabe, F. Sakamoto, N. Tsuda, Y. Shimohigashi, Y. Yamashita, N. Oya
  • Organizer: ESTRO 37
  • Int'l Joint Research