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An integrated research of advanced coronary artery imaging and multi-biomarkers for investigation into progression of arteriosclerosis in the patients with Kawasaki disease

Research Project

Project/Area Number 18K07787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Takamichi Ishikawa  浜松医科大学, 医学部, 准教授 (30402283)

Co-Investigator(Kenkyū-buntansha) 關 圭吾  浜松医科大学, 医学部附属病院, その他 (20626345)
内山 弘基  浜松医科大学, 医学部附属病院, 助教 (30840516)
大谷 速人  浜松医科大学, 医学部附属病院, 特任講師 (60794972)
茂木 聡  浜松医科大学, 医学部附属病院, 診療助教 (60573368)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords光干渉断層法 / 川崎病 / 動脈硬化
Outline of Final Research Achievements

The coronary artery wall was evaluated by optical coherence tomography (OCT) in a normal control group (3 cases, 8 vessels) and a group with coronary artery lesions (CAL) due to Kawasaki disease (KD) (CAL group (6 cases, 15 vessels). The CAL group had significant intimal thickening (p=0.030), loss of the media (p<0.001), and angiogenesis (vasa vasorum) (p=0.002). Furthermore, even in KD patients hadwhere had regressed coronary aneurysms or without CAL was observed destruction of the three-layer structure of the coronary artery wall and angiogenesis.

Academic Significance and Societal Importance of the Research Achievements

本研究では川崎病冠動脈瘤群では正常コントロール群に比べ冠動脈内膜肥厚、中膜消失や新生血管が有意に認められた。さらに急性期に冠動脈病変を認めない症例においても,冠動脈壁三層構造の破壊や新生血管の発達を認めることが明らかになった。現在の川崎病治療は「冠動脈後遺症を残さない」点に重点が置かれており、冠動脈後遺症が残存しないもしくは退縮した場合、川崎病遠隔期のフォローは発症後5年程度で中止されることが多い。本研究結果は川崎病管理において「患者毎の動脈硬化リスク層別化」「早期動脈硬化リスクを軽減するための治療戦略の構築」を考える上で有益なエビデンスとなりうる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] 川崎病既往患者と動脈硬化に関する研究2024

    • Author(s)
      石川 貴充, 内山 弘基, 茂木 聡, 大谷 速人
    • Journal Title

      アレルギーの臨床

      Volume: 44(1) Pages: 83-87

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Editorial for “Quantitative Assessment of Myocardial Edema by <scp>MR T2</scp> Mapping in Children With Kawasaki Disease”2023

    • Author(s)
      Ishikawa Takamichi、Suwa Kenichiro
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 59 Issue: 3 Pages: 835-836

    • DOI

      10.1002/jmri.28851

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クリニカルトピックス 川崎病患者における動脈硬化進展の病態を探る2023

    • Author(s)
      石川 貴充, 内山 弘基, 茂木 聡, 大谷 速人
    • Journal Title

      BIO Clinica

      Volume: 38(5) Pages: 434-437

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 集中治療により救命し得たびまん性新生児血管腫症2023

    • Author(s)
      柳瀬 佑馬, 石川 貴充, 内山 弘基
    • Journal Title

      小児科臨床

      Volume: 76(2) Pages: 261-265

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of intravenous propranolol for life‐threatening diffuse neonatal hemangiomatosis2022

    • Author(s)
      Ishikawa Takamichi、Seki Keigo、Uchiyama Hiroki
    • Journal Title

      Pediatric Dermatology

      Volume: 39 Issue: 4 Pages: 613-615

    • DOI

      10.1111/pde.15028

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural changes in the coronary vessel wall in a patient with incomplete Kawasaki disease.2022

    • Author(s)
      Ishikawa T, Uchiyama H, Mogi S, Ohtani H
    • Journal Title

      Front Pediatr

      Volume: 10 Pages: 845723-845723

    • DOI

      10.3389/fped.2022.845723

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 川崎病遠隔期における早期動脈硬化病変の進展に関する研究.2022

    • Author(s)
      石川貴充, 内山弘基, 茂木聡, 大谷速人
    • Journal Title

      BIO Clinica

      Volume: 37 Pages: 57-60

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 川崎病後の動脈硬化進展に関する冠動脈先端画像法を用いたマルチバイオマーカーとの融合研究.2021

    • Author(s)
      石川貴充, 内山弘基, 茂木聡, 大谷速人
    • Journal Title

      Precision Medicine

      Volume: 4 Pages: 565-568

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between congenital heart disease and small for gestational age with regard to the prevalence and outcomes2021

    • Author(s)
      Ishikawa T, Uchiyama H, Baba T, Ohishi A, Iijima S, Iwashima S
    • Journal Title

      Acta Paediatr

      Volume: 110 Issue: 3 Pages: 1009-1016

    • DOI

      10.1111/apa.15587

    • NAID

      120007173426

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic changes in neonates born to mothers with Graves' disease2021

    • Author(s)
      Ishikawa T, Uchiyama H, Iwashima S, Baba T, Ohishi A, Iijima S, Itoh H
    • Journal Title

      Endocrine

      Volume: 72 Issue: 1 Pages: 171-178

    • DOI

      10.1007/s12020-020-02443-w

    • NAID

      120007169759

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] TSC1 intragenic deletion transmitted from a mosaic father to two siblings with cardiac rhabdomyomas: Identification of two aberrant transcripts2020

    • Author(s)
      Uchiyama H, Masunaga Y, Ishikawa T, Fukuoka T, Fukami M, Saitsu H, Ogata T
    • Journal Title

      Eur J Med Genet

      Volume: 63 Pages: 104060-104060

    • NAID

      120007173432

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful Management of Pulmonary Arterial Hypertension by Monitoring N-Terminal Pro-B-Type Natriuretic Peptide Serum Levels in a Preterm Infant with Chronic Lung Disease: A Case Report.2019

    • Author(s)
      Seki K, Iwashima S, Uchiyama H, Ohishi A, Ishikawa T
    • Journal Title

      AJP Rep.

      Volume: 9 Issue: 02 Pages: e133-e137

    • DOI

      10.1055/s-0039-1684026

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Closure time of ductus arteriosus after birth based on survival analysis.2018

    • Author(s)
      Iwashima S, Satake E, Uchiyama H, Seki K, Ishikawa T.
    • Journal Title

      Early Hum Dev.

      Volume: 121 Pages: 37-43

    • DOI

      10.1016/j.earlhumdev.2018.05.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Oxidative Stress in Children With Left to Right Shunt Congenital Heart Disease2020

    • Author(s)
      Ishikawa T, Uchiyama H
    • Organizer
      American Heart Association Scientific Sessions 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] バセドウ病合併母体から出生した児の心機能2020

    • Author(s)
      石川貴充、内山弘基
    • Organizer
      第56回日本小児循環器学会総会・学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 左右短絡先天性心疾患における酸化ストレス2019

    • Author(s)
      石川貴充、内山弘基
    • Organizer
      第55回日本小児循環器学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] The Association Between Small For Gestational Age And Congenital Heart Disease As Assessed By Echocardiography In 6041 Consecutive Newborns.2018

    • Author(s)
      Ishikawa T, Seki K.
    • Organizer
      American Heart Association’s Scientific Sessions, November 10-13, 2018, Chicago, IL, USA.
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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