Analysis of the molecular basis of MERS-delirious behavior spectrum

• Project/Area Number: 18K07890
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Aichi Medical University
• Principal Investigator: Okumura Akihisa 愛知医科大学, 医学部, 教授 (60303624)
• Co-Investigator(Kenkyū-buntansha): 増田 章男 名古屋大学, 医学系研究科, 准教授 (10343203) ; 倉橋 宏和 愛知医科大学, 医学部, 講師 (30621817) ; 早川 昌弘 名古屋大学, 医学部附属病院, 病院教授 (40343206)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: MYRF / MERS / 異常言動 / 遺伝子解析 / 可逆性脳梁病変 / MERS－異常言動スペクトラム

Outline of Final Research Achievements

A common missense mutation in the MYRF gene was identified by whole exome analysis in familial patients with recurrent mild encephalitis/ encephalopathy with reversible splenial lesion (MERS). Whole exome analysis was performed in other patients with MERS, and a novel missense MYRF gene mutation was identified in another patient with recurrent leukoencephalopathy.
Variants in about 700 genes potentially regulated by MYRF have been analyzed in patients with repetitive and/or familial MERS and compared to controls without neurological disorders. In patients with MERS, variants in GFOD1, HEMK1, CDIP1, PCSK6, LGMN and SLC5A11 genes tended to be more common than in controls. No clear conclusions can be reached at present on the association between these gene variants and the development of MERS.

Academic Significance and Societal Importance of the Research Achievements

MERS-異常言動スペクトラムの原因としてMYRF遺伝子の関与が明らかになり、感染を契機に発症する神経症状の分子生物学的な基盤を解明する糸口となることが予想される。MERS症例でMYRFと関連する遺伝子のバリアントが相対的に多いことは、MYRFの関与を間接的に支持する根拠となる。インフルエンザに伴う異常言動は社会的に大きなインパクトを与えたが、我々の研究によって遺伝学的因子の関与が示唆されたことにより、その適切な理解を促すことにつながることが予想される。

Research Products

• [Journal Article] Acute encephalopathy with biphasic seizures and late reduced diffusion: Predictive EEG findings (2022)
  • Author(s): Ohno A, Okumura A, Fukasawa T, Nakata T, Suzuki M, Tanaka M, Okai Y, Ito Y, Yamamoto H, Tsuji T, Kidokoro H, Saitoh S, Natsume J.
  • Journal Title: Brain Dev Volume: 44(3) Issue: 3 Pages: 221-228
  • DOI: 10.1016/j.braindev.2021.11.003
  • Peer Reviewed
• [Journal Article] Subcortical infarction in a young adult with Hunter syndrome (2022)
  • Author(s): Kimura M, Azuma Y, Taguchi S, Takagi M, Mori H, Shimomura Y, Niwa JI, Doyu M, Okumura A.
  • Journal Title: Brain Dev Volume: 44(5) Issue: 5 Pages: 343-346
  • DOI: 10.1016/j.braindev.2022.01.003
  • Peer Reviewed
• [Journal Article] Case report: Mild encephalitis with a reversible splenial lesion associated with SARS-CoV-2 infection in a patient with MYRF variant (2022)
  • Author(s): Saito Mizuho、Nakazawa Tomoyuki、Toriumi Shun、Takasu Michihiko、Yagisawa Hiromi、Murano Yayoi、Miyazaki Nao、Kurahashi Hirokazu、Okumura Akihisa、Shimizu Toshiaki
  • Journal Title: Frontiers in Pediatrics Volume: 10 Pages: 971432-971432
  • DOI: 10.3389/fped.2022.971432
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome analysis of 177 pediatric patients with undiagnosed diseases. (2022)
  • Author(s): Narita K, Muramatsu H, Narumi S, Nkawa T, Okumura A, et al.
  • Journal Title: Sci Rep Volume: 12(1) Issue: 1 Pages: 14589-14589
  • DOI: 10.1038/s41598-022-14161-6
  • Peer Reviewed / Open Access
• [Journal Article] Case report: Five patients with myocarditis after mRNA COVID-19 vaccination (2022)
  • Author(s): Murase Hiroki、Zhu Yiqing、Sakaida Keiya、Mizuno Hayato、Mori Hiromitsu、Iwayama Hideyuki、Suzuki Noriyuki、Nagai Noriko、Okumura Akihisa
  • Journal Title: Frontiers in Pediatrics Volume: 10 Pages: 977476-977476
  • DOI: 10.3389/fped.2022.977476
  • Peer Reviewed / Open Access
• [Journal Article] Human herpesvirus 6 <scp>DNA</scp> was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection (2022)
  • Author(s): Kawamura Yoshiki、Maesawa Satoshi、Numoto Shingo、Saito Ryuta、Yoshikawa Tetsushi、Okumura Akihisa
  • Journal Title: Epilepsia Open Volume: 7 Issue: 4 Pages: 817-821
  • DOI: 10.1002/epi4.12634
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of Q-Probe PCR in Detecting Macrolide-Resistant <i>Mycoplasma pneumoniae</i> Infection in Children (2021)
  • Author(s): Muto T, Nakamura N, Masuda Y, Numoto S, Kodama S, Miyamoto R, Hayakawa T, Mori H, Iwayama H, Kurahashi H, Agata H, Okumura
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 75 Issue: 1 Pages: 89-91
  • DOI: 10.7883/yoken.JJID.2021.003
  • NAID: 130008143946
  • ISSN: 1344-6304, 1884-2836
  • Year and Date: 2021-01-31
  • Peer Reviewed
• [Journal Article] A pilot study of serum free carnitine levels in hospitalized febrile children. (2021)
  • Author(s): Okumura A, Muto T, Nakamura N, Masuda Y, Kodama S.
  • Journal Title: Pediatr Int. Volume: 63 Issue: 1 Pages: 102-103
  • DOI: 10.1111/ped.14360
  • Peer Reviewed
• [Journal Article] Auditory brainstem response in preterm infants with bilirubin encephalopathy (2021)
  • Author(s): Okumura Akihisa、Kitai Yukihiro、Arai Hiroshi、Hayakawa Masahiro、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Kumada Satoko、Morioka Ichiro
  • Journal Title: Early Human Development Volume: 154 Pages: 105319-105319
  • DOI: 10.1016/j.earlhumdev.2021.105319
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic resonance imaging abnormalities during the neonatal period in preterm infants with bilirubin encephalopathy. (2021)
  • Author(s): Okumura A, Kitai Y, Arai H.
  • Journal Title: Pediatr Neonatol. Volume: 62 Issue: 5 Pages: 567-568
  • DOI: 10.1016/j.pedneo.2021.03.013
  • Peer Reviewed
• [Journal Article] Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate. (2021)
  • Author(s): Okumura A, Numoto S, Iwayama H, Azuma Y, Kurahashi H.
  • Journal Title: Epilepsy Behav. Volume: 117 Pages: 107883-107883
  • DOI: 10.1016/j.yebeh.2021.107883
  • Peer Reviewed
• [Journal Article] Neonatal Jaundice in Preterm Infants with Bilirubin Encephalopathy (2021)
  • Author(s): Okumura Akihisa、Ichimura Shintaro、Hayakawa Masahiro、Arai Hiroshi、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Kumada Satoko、Morioka Ichiro
  • Journal Title: Neonatology Volume: 19 Issue: 3 Pages: 1-9
  • DOI: 10.1159/000513785
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic Resonance Imaging Findings in Preterm Infants With Bilirubin Encephalopathy Beyond Three Years Corrected Age. (2021)
  • Author(s): Okumura A, Kitai Y, Arai H, Hayakawa M, Maruo Y, Kusaka T, Kunikata T, Kumada S, Morioka I.
  • Journal Title: Pediatr Neurol. Volume: 121 Pages: 56-58
  • DOI: 10.1016/j.pediatrneurol.2021.05.019
  • Peer Reviewed
• [Journal Article] Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate (2021)
  • Author(s): Okumura Akihisa、Takagi Mizuki、Numoto Shingo、Iwayama Hideyuki、Azuma Yoshiteru、Kurahashi Hirokazu
  • Journal Title: Epilepsy &amp; Behavior Volume: 122 Pages: 108220-108220
  • DOI: 10.1016/j.yebeh.2021.108220
  • Peer Reviewed
• [Journal Article] Guidelines for the diagnosis and treatment of acute encephalopathy in childhood (2021)
  • Author(s): Mizuguchi Masashi、Ichiyama Takashi、Imataka George、Okumura Akihisa、Goto Tomohide、Sakuma Hiroshi、Takanashi Jun-ichi、Murayama Kei、Yamagata Takanori、Yamanouchi Hideo、Fukuda Tokiko、Maegaki Yoshihiro
  • Journal Title: Brain and Development Volume: 43 Issue: 1 Pages: 2-31
  • DOI: 10.1016/j.braindev.2020.08.001
  • Peer Reviewed
• [Journal Article] Three-Year Longitudinal Motor Function and Disability Level of Acute Flaccid Myelitis (2021)
  • Author(s): Chong Pin Fee、Kira Ryutaro、Torisu Hiroyuki、Yasumoto Sawa、Okumura Akihisa、Mori Harushi、Tanaka-Taya Keiko.
  • Journal Title: Pediatric Neurology Volume: 116 Pages: 14-19
  • DOI: 10.1016/j.pediatrneurol.2020.11.019
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in children with tuberous sclerosis complex. (2021)
  • Author(s): Numoto S, Kurahashi H, Sato A, Kubota M, Shiihara T, Okanishi T, Tanaka R, Kuki I, Fukuyama T, Kashiwagi M, Ikeno M, Kubota K, Akasaka M, Mimaki M, Okumura
  • Journal Title: Orphanet J Rare Dis. Volume: 16 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s13023-020-01646-8
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the Diagnostic Criteria for Anti-NMDA Receptor Encephalitis in Japanese Children. (2021)
  • Author(s): Nishida H, Kohyama K, Kumada S, Takanashi JI, Okumura A, Horino A, Moriyama K, Sakuma H.
  • Journal Title: Neurology. Volume: 96 Issue: 16
  • DOI: 10.1212/wnl.0000000000011789
  • Peer Reviewed
• [Journal Article] Repetitive sleep starts: An important differential diagnosis of infantile spasms. (2021)
  • Author(s): Maki Y, Kidokoro H, Okumura A, Yamamoto H, Nakata T, Fukasawa T, Kubota T, Kawaguchi M, Suzuki T, Tanaka M, Okai Y, Sakaguchi Y, Ohno A, Negoro T, Takahashi Y, Natsume J.
  • Journal Title: Epilepsy Behav. Volume: 121 Pages: 108075-108075
  • DOI: 10.1016/j.yebeh.2021.108075
  • Peer Reviewed
• [Journal Article] Clinical and electrophysiological features of acute flaccid myelitis: A national cohort study. (2021)
  • Author(s): Chong PF, Torisu H, Yasumoto S, Okumura A, Mori H, Sato T, Kimura J, Ohga S, Tanaka-Taya K, Kira R
  • Journal Title: Clin Neurophysiol. Volume: 132 Issue: 10 Pages: 2456-2463
  • DOI: 10.1016/j.clinph.2021.07.013
  • Peer Reviewed / Open Access
• [Journal Article] Regional Difference in Myelination in Monocarboxylate Transporter 8 Deficiency: Case Reports and Literature Review of Cases in Japan (2021)
  • Author(s): Iwayama Hideyuki、Tanaka Tatsushi、Aoyama Kohei、Moroto Masaharu、Adachi Shinsuke、Fujisawa Yasuko、Matsuura Hiroki、Takano Kyoko、Mizuno Haruo、Okumura Akihisa
  • Journal Title: Frontiers in Neurology Volume: 12 Pages: 657820-657820
  • DOI: 10.3389/fneur.2021.657820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Measurement of Reverse Triiodothyronine Level and the Triiodothyronine to Reverse Triiodothyronine Ratio in Dried Blood Spot Samples at Birth May Facilitate Early Detection of Monocarboxylate Transporter 8 Deficiency (2021)
  • Author(s): Iwayama Hideyuki、Kakita Hiroki、Iwasa Masumi、Adachi Shinsuke、Takano Kyoko、Kikuchi Masahiro、Fujisawa Yasuko、Osaka Hitoshi、Yamada Yasumasa、Okumura Akihisa、Hirani Khemraj、Weiss Roy E.、Refetoff Samuel
  • Journal Title: Thyroid Volume: 31 Issue: 9 Pages: 696-696
  • DOI: 10.1089/thy.2020.0696
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sodium channel blockers are effective for benign infantile epilepsy. (2021)
  • Author(s): Numoto S, Kurahashi H, Takagi M, Azuma Y, Iwayama H, Okumura A.
  • Journal Title: Seizure Volume: 92 Pages: 207-210
  • DOI: 10.1016/j.seizure.2021.09.008
  • Peer Reviewed
• [Journal Article] Respiratory illness and acute flaccid myelitis in the Tokai district in 2018 (2020)
  • Author(s): Okumura Akihisa、Numoto Shingo、Iwayama Hideyuki、Kurahashi Hirokazu、Natsume Jun、Saitoh Shinji、Yoshikawa Tetsushi、Fukao Toshiyuki、Hirayama Masahiro、Takahashi Yoshiyuki
  • Journal Title: Pediatrics International Volume: 62 Issue: 3 Pages: 337-340
  • DOI: 10.1111/ped.14128
  • Peer Reviewed
• [Journal Article] A nationwide survey of bilirubin encephalopathy in preterm infants in Japan (2020)
  • Author(s): Okumura Akihisa、Morioka Ichiro、Arai Hiroshi、Hayakawa Masahiro、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Kumada Satoko
  • Journal Title: Brain and Development Volume: 42 Issue: 10 Pages: 730-737
  • DOI: 10.1016/j.braindev.2020.06.010
  • Peer Reviewed / Open Access
• [Journal Article] Clinical findings in patients with febrile seizure after 5?years of age: A retrospective study (2020)
  • Author(s): Ogino Motoko、Kashiwagi Mitsuru、Tanabe Takuya、Oba Chizu、Nomura Shohei、Shimakawa Shuichi、Kidokoro Hiroyuki、Natsume Jun、Okumura Akihisa、Tamai Hiroshi、Ashida Akira
  • Journal Title: Brain and Development Volume: 20 Issue: 6 Pages: 449-456
  • DOI: 10.1016/j.braindev.2020.02.009
  • Peer Reviewed
• [Journal Article] Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014-2017 (2020)
  • Author(s): Kasai Mariko、Shibata Akiko、Hoshino Ai、Maegaki Yoshihiro、Yamanouchi Hideo、Takanashi Jun-ichi、Yamagata Takanori、Sakuma Hiroshi、Okumura Akihisa、Nagase Hiroaki、Ishii Atsushi、Goto Tomohide、Oka Akira、Mizuguchi Masashi
  • Journal Title: Brain and Development Volume: ー Issue: 7 Pages: 508-514
  • DOI: 10.1016/j.braindev.2020.04.006
  • Peer Reviewed
• [Journal Article] Transient cortical diffusion restriction in children immediately after prolonged febrile seizures (2020)
  • Author(s): Suzuki Takeshi、Kidokoro Hiroyuki、Kubota Tetsuo、Fukasawa Tatsuya、Suzui Ryosuke、Tsuji Takeshi、Kato Toru、Yamamoto Hiroyuki、Ohno Atsuko、Nakata Tomohiko、Saitoh Shinji、Okumura Akihisa、Natsume Jun
  • Journal Title: European Journal of Paediatric Neurology Volume: 27 Pages: 30-36
  • DOI: 10.1016/j.ejpn.2020.05.004
  • Peer Reviewed
• [Journal Article] A trial of lacosamide for benign convulsions with gastroenteritis (2020)
  • Author(s): Numoto Shingo、Kurahashi Hirokazu、Iwayama Hideyuki、Okumura Akihisa
  • Journal Title: Brain and Development Volume: 42 Issue: 7 Pages: 551-554
  • DOI: 10.1016/j.braindev.2020.03.006
  • Peer Reviewed
• [Journal Article] Splenial lesions in benign convulsions with gastroenteritis associated with rotavirus infection (2019)
  • Author(s): Ogawa Chikako、Kidokoro Hiroyuki、Ishihara Naoko、Tsuji Takeshi、Kurahashi Hirokazu、Hattori Ayako、Suzuki Motomasa、Ogaya Shunsuke、Ito Yuji、Fukasawa Tatsuya、Kubota Tetsuo、Okumura Akihisa、Saitoh Shinji、Natsume Jun
  • Journal Title: Pediatric Neurology Volume: 9 Pages: 79-84
  • DOI: 10.1016/j.pediatrneurol.2019.05.002
  • Peer Reviewed
• [Journal Article] Serial MRI findings of acute flaccid myelitis during an outbreak of enterovirus D68 infection in Japan (2019)
  • Author(s): Okumura Akihisa、Mori Harushi、Fee Chong Pin、Kira Ryutaro、Torisu Hiroyuki、Yasumoto Sawa、Shimizu Hiroyuki、Fujimoto Tsuguto、Tanaka-Taya Keiko
  • Journal Title: Brain and Development Volume: 41 Issue: 5 Pages: 443-451
  • DOI: 10.1016/j.braindev.2018.12.001
  • Peer Reviewed
• [Journal Article] Serum carnitine levels of children with epilepsy: Related factors including valproate (2019)
  • Author(s): Okumura Akihisa、Kurahashi Hirokazu、Iwayama Hideyuki、Numoto Shingo
  • Journal Title: Brain and Development Volume: 41 Issue: 6 Pages: 516-521
  • DOI: 10.1016/j.braindev.2019.02.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PRRT2 mutations in Japanese patients with benign infantile epilepsy and paroxysmal kinesigenic dyskinesia (2019)
  • Author(s): Okumura Akihisa、Shimojima Keiko、Kurahashi Hirokazuら.
  • Journal Title: Seizure Volume: 71 Pages: 1-5
  • DOI: 10.1016/j.seizure.2019.05.017
  • Peer Reviewed
• [Journal Article] The effects of antihistamines on the semiology of febrile seizures (2019)
  • Author(s): Takasu Michihiko、Kubota Tetsuo、Tsuji Takeshi、Kurahashi Hirokazu、Numoto Shingo、Okumura Akihisa
  • Journal Title: Brain and Development Volume: 41 Issue: 1 Pages: 72-76
  • DOI: 10.1016/j.braindev.2018.07.005
  • Peer Reviewed
• [Journal Article] A nationwide survey of norovirus-associated encephalitis/encephalopathy in Japan (2019)
  • Author(s): Shima Taiki、Okumura Akihisa、Kurahashi Hirokazu、Numoto Shingo、Abe Shinpei、Ikeno Mitsuru、Shimizu Toshiaki
  • Journal Title: Brain and Development Volume: 41 Issue: 3 Pages: 263-270
  • DOI: 10.1016/j.braindev.2018.11.001
  • Peer Reviewed
• [Journal Article] Comprehensive clinical and molecular studies in split-hand/foot malformation: identification of two plausible candidate genes (LRP6 and UBA2) (2019)
  • Author(s): Yamoto Kaori、Saitsu Hirotomo、Nishimura Gen、Kosaki Rika、Takayama Shinichiro、Haga Nobuhiko、Tonoki Hidefumi、Okumura Akihisa、Horii Emiko、Okamoto Nobuhiko、Suzumura Hiroshi、Ikegawa Shiro、Kato Fumiko、Fujisawa Yasuko、Nagata Eiko、Takada Shuji、Fukami Maki、Ogata Tsutomu
  • Journal Title: European Journal of Human Genetics Volume: 27 Issue: 12 Pages: 1845-1857
  • DOI: 10.1038/s41431-019-0473-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Delayed recognition of childhood arterial ischemic stroke (2019)
  • Author(s): Hori Ikumi、Tsuji Takeshi、Miyake Misa、Ueda Kazuto、Kataoka Erina、Suzuki Michio、Kobayashi Satoru、Kurahashi Hirokazu、Takahashi Yoshiyuki、Okumura Akihisa、Yoshikawa Tetsushi、Saitoh Shinji、Natsume Jun
  • Journal Title: Pediatrics International Volume: 61 Issue: 9 Pages: 895-903
  • DOI: 10.1111/ped.13966
  • Peer Reviewed
• [Journal Article] Genomic backgrounds of Japanese patients with undiagnosed neurodevelopmental disorders (2019)
  • Author(s): Yamamoto Toshiyuki、Imaizumi Taichi、Yamamoto-Shimojima Keiko、Kurahashi Hirokazuら,
  • Journal Title: Brain and Development Volume: 41 Issue: 9 Pages: 776-782
  • DOI: 10.1016/j.braindev.2019.05.007
  • Peer Reviewed
• [Journal Article] Vitamin B1 Deficiency Related to Excessive Soft Drink Consumption in Japan. (2018)
  • Author(s): Okumura Akihisa、On behalf of the Committee on Pediatric Nutrition of The Japanese Pediatric Society、Ida Shinobu、Mori Masaaki、Shimizu Toshiaki
  • Journal Title: Journal of Pediatric Gastroenterology and Nutrition Volume: 66 Issue: 5 Pages: 838-842
  • DOI: 10.1097/mpg.0000000000001839
  • Peer Reviewed
• [Journal Article] Attitudes of pediatricians toward Children’s consumption of ionic beverages (2018)
  • Author(s): Okumura Akihisa、On behalf of the Committee on Pediatric Nutrition of The Japanese Pediatric Society、Ida Shinobu、Mori Masaaki、Shimizu Toshiaki
  • Journal Title: BMC Pediatrics Volume: 18 Issue: 1 Pages: 176-176
  • DOI: 10.1186/s12887-018-1154-3
  • Peer Reviewed / Open Access
• [Journal Article] A patient with a GNAO1 mutation with decreased spontaneous movements, hypotonia, and dystonic features (2018)
  • Author(s): Okumura Akihisa、Maruyama Koichi、Shibata Mami、Kurahashi Hirokazu、Ishii Atsushi、Numoto Shingo、Hirose Shinichi、Kawai Tomoko、Iso Manami、Kataoka Shinsuke、Okuno Yusuke、Muramatsu Hideki、Kojima Seiji
  • Journal Title: Brain and Development Volume: 40 Issue: 10 Pages: 926-930
  • DOI: 10.1016/j.braindev.2018.06.005
  • Peer Reviewed
• [Journal Article] Parental awareness of young children's pattern of ionic beverage consumption (2018)
  • Author(s): Okumura Akihisa、Ida Shinobu、Ito Setsuko、Oguni Tatsuya、Suzuki Mitsuyoshi、Mori Masaaki、Shimizu Toshiaki、the Committee on Pediatric Nutrition of the Japanese Pediatric Society
  • Journal Title: Pediatrics International Volume: 60 Issue: 10 Pages: 969-973
  • DOI: 10.1111/ped.13666
  • Peer Reviewed
• [Journal Article] Acute Flaccid Myelitis Collaborative Study I. Clinical Features of Acute Flaccid Myelitis Temporally Associated With an Enterovirus D68 Outbreak: Results of a Nationwide Survey of Acute Flaccid Paralysis in Japan, August-December 2015 (2018)
  • Author(s): Chong PF, Kira R, Mori H, Okumura A, Torisu H, Yasumoto S, Shimizu H, Fujimoto T, Hanaoka N, Kusunoki S, Takahashi T, Oishi K, Tanaka-Taya K
  • Journal Title: Clin Infect Dis Volume: 66 Issue: 5 Pages: 653-664
  • DOI: 10.1093/cid/cix860
  • Peer Reviewed
• [Journal Article] Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction (2018)
  • Author(s): Kurahashi, H., Takami, A., Murotani, K., Numoto, S. and Okumura, A.
  • Journal Title: Int J Hematol Volume: 107 Issue: 1 Pages: 105-111
  • DOI: 10.1007/s12185-017-2323-0
  • Peer Reviewed
• [Journal Article] MYRF is associated with encephalopathy with reversible myelin vacuolization (2018)
  • Author(s): Kurahashi Hirokazu、Azuma Yoshiteru、Masuda Akio、Okuno Tatsuya、Nakahara Eri、Imamura Takuji、Saitoh Makiko、Mizuguchi Masashi、Shimizu Toshiaki、Ohno Kinji、Okumura Akihisa
  • Journal Title: Annals of Neurology Volume: 83 Issue: 1 Pages: 98-106
  • DOI: 10.1002/ana.25125
  • Peer Reviewed / Open Access
• [Journal Article] A One-Month-Old Boy With a Seizure During a Febrile Illness (2018)
  • Author(s): Muto Taichiro、Nago Nozomi、Kurahashi Hirokazu、Minagawa Hiroko、Okumura Akihisa
  • Journal Title: Clinical Pediatrics Volume: 57 Issue: 3 Pages: 355-357
  • DOI: 10.1177/0009922817691827
  • Peer Reviewed
• [Journal Article] The efficacy of adrenocorticotropic hormone in a girl with anti-N-methyl-D-aspartate receptor encephalitis (2018)
  • Author(s): Hatanaka Mari、Shimakawa Shuichi、Okumura Akihisa、Natsume Jun、Fukui Miho、Nomura Shohei、Kashiwagi Mitsuru、Tamai Hiroshi
  • Journal Title: Brain and Development Volume: 40 Issue: 3 Pages: 247-250
  • DOI: 10.1016/j.braindev.2017.10.003
  • Peer Reviewed
• [Journal Article] Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review (2018)
  • Author(s): Iwayama Hideyuki、Hirase Sho、Nomura Yuka、Ito Tatsuo、Morita Hiroyuki、Otake Kazuo、Okumura Akihisa、Takagi Junko
  • Journal Title: BMC Endocrine Disorders Volume: 18 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s12902-018-0246-2
  • Peer Reviewed / Open Access
• [Journal Article] Cytokine-induced differentiation of hematopoietic cells into microglia-like cells in?vitro (2018)
  • Author(s): Igarashi Ayuko、Sakuma Hiroshi、Hayashi Masaharu、Noto Daisuke、Miyake Sachiko、Okumura Akihisa、Shimizu Toshiaki
  • Journal Title: Clinical and Experimental Neuroimmunology Volume: 8 Issue: 2 Pages: 139-149
  • DOI: 10.1111/cen3.12429
  • Peer Reviewed / Open Access
• [Journal Article] Survey of rotavirus-associated severe complications in Aichi Prefecture (2018)
  • Author(s): Hattori, F. Kawamura, Y. Kawada, J. I. Kojima, S. Natsume, J. Ito, K. Saito, S. Kitagawa, Y. Okumura, A. Yoshikawa, T.
  • Journal Title: Pediatr Int Volume: 60 Issue: 3 Pages: 259-263
  • DOI: 10.1111/ped.13506
  • Peer Reviewed
• [Journal Article] A rare case of fetal extensive intracranial hemorrhage and whole-cerebral hypoplasia due to latent maternal vitamin K deficiency (2018)
  • Author(s): Goto T.、Kakita H.、Takasu M.、Takeshita S.、Ueda H.、Muto D.、Kondo T.、Kurahashi H.、Okumura A.、Yamada Y.
  • Journal Title: Journal of Neonatal-Perinatal Medicine Volume: 11 Issue: 2 Pages: 191-194
  • DOI: 10.3233/npm-181745
  • Peer Reviewed
• [Journal Article] Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma (2018)
  • Author(s): Miyata Kenji、Hori Toshinori、Shimomura Yasuto、Joko Masahiro、Takayasu Masakazu、Okumura Akihisa
  • Journal Title: Child's Nervous System Volume: 34 Issue: 11 Pages: 2305-2308
  • DOI: 10.1007/s00381-018-3841-7
  • Peer Reviewed
• [Presentation] Neurophysiological Aspects of Neonatal Seizures and Other Neurological Disorders (2022)
  • Author(s): Akihisa Okumura
  • Organizer: The 6th Azalea Festival Symposium in Pediatric Neurology
  • Int'l Joint Research / Invited
• [Presentation] 病原体による急性脳症の経年的変化と表現型 (2022)
  • Author(s): 奥村彰久
  • Organizer: 第64回日本小児神経学会学術集会
• [Presentation] HHV-6によるけいれん性てんかん重積に続発した内側側頭葉硬化病変のウイルス学的解析 (2022)
  • Author(s): 奥村彰久、河村吉紀、前澤聡、沼本真吾、斎藤竜太、吉川哲史
  • Organizer: 第26回日本神経感染症学会学術大会
• [Presentation] Amplitude-integrated EEG in Paediatric Patients: What is aEEG (2021)
  • Author(s): Akihisa Okumura.
  • Organizer: The 13th Asian & Oceanian Epilepsy Congress
  • Int'l Joint Research / Invited
• [Presentation] Amplitude-integrated EEG in Paediatric Patients: aEEG in Children (2021)
  • Author(s): Akihisa Okumura.
  • Organizer: The 13th Asian & Oceanian Epilepsy Congress
  • Int'l Joint Research / Invited
• [Presentation] 新生児発作の診断と治療 (2021)
  • Author(s): 奥村彰久
  • Organizer: 第54回日本てんかん学会学術集会
  • Invited
• [Presentation] 小児急性脳炎・脳症の変遷：全国調査から (2021)
  • Author(s): 奥村彰久
  • Organizer: 第25回日本神経感染症学会学術大
  • Invited
• [Presentation] バルプロ酸を内服中のてんかん患者におけるカルニチン補充の効果 (2021)
  • Author(s): 奥村彰久、沼本真吾、東慶輝、倉橋宏和
  • Organizer: 第54回日本てんかん学会学術集会
• [Presentation] レジストリーの経過と成果：東海小児神経研究会の歩み (2020)
  • Author(s): 奥村彰久
  • Organizer: 第62回日本小児神経学会学術集会
• [Presentation] 早産児慢性ビリルビン脳症の臨床像：全国調査結果から (2019)
  • Author(s): 奥村彰久、森岡一朗 、早川昌弘、日下隆、國方徹
  • Organizer: 第55回日本周産期・新生児医学会学術集会
• [Presentation] Classification of neonatal seizures (2019)
  • Author(s): Akihisa Okumura
  • Organizer: The 15th Asian and Oceanian Congress of Child Neurology
  • Int'l Joint Research / Invited
• [Presentation] 新生児単純ヘルペス脳炎 (2019)
  • Author(s): 奥村彰久
  • Organizer: 第24回日本神経感染症学会学術大会
  • Invited
• [Presentation] Serum Carnitine Levels of Children with Epilepsy: Related Factors Including Valproate (2019)
  • Author(s): Akihisa Okumura, Hirokazu Kurahashi, Shingo Numoto.
  • Organizer: 第53回日本てんかん学会学術集会
• [Presentation] 早産児慢性ビリルビン脳症の新生児期の光線療法と合併症の実態 (2019)
  • Author(s): 奥村彰久、荒井洋、森岡一朗、早川昌弘、日下隆、丸尾良浩、國方徹也、熊田聡子
  • Organizer: 第64回日本新生児成育医学会学術集会
• [Presentation] 早産児の慢性ビリルビン脳症（核黄疸）の臨床像 (2018)
  • Author(s): 奥村彰久
  • Organizer: 第121回日本小児科学会学術集会
  • Invited
• [Presentation] イオン飲料水の多飲によるビタミンB1欠乏症 (2018)
  • Author(s): 奥村彰久
  • Organizer: 第121回日本小児科学会学術集会
  • Invited
• [Presentation] 小児急性脳症診療ガイドラインのポイント (2018)
  • Author(s): 奥村彰久
  • Organizer: 第60回日本小児神経学会学術集会
  • Invited
• [Presentation] 小児の急性脳症Up to Date (2018)
  • Author(s): 奥村彰久
  • Organizer: 第25回日本小児高血圧研究会
  • Invited
• [Presentation] エンテロウイルスD68流行期の急性弛緩性脊髄炎の臨床像と画像所見 (2018)
  • Author(s): 奥村彰久
  • Organizer: 第23回日本神経感染症学会学術大会
  • Invited
• [Presentation] イオン飲料水などの多飲によるビタミンB1欠乏症 (2018)
  • Author(s): 奥村彰久
  • Organizer: 日本ビタミン学会創立70周年記念シンポジウム
  • Invited
• [Book] Acute Encephalopathy and Encephalitis in Infancy and Its Related Disorders (2018)
  • Author(s): Yamonouchi H, Moshe SL, Okumura A
  • Total Pages: 350
  • Publisher: Elsevier
  • ISBN: 9780323530880