| Project/Area Number |
18K07950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 大腸癌 / 化学予防 / オルガノイド / アスピリン / メトホルミン / 大腸発癌 / 大腸腫瘍 |
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| Outline of Final Research Achievements |
Colorectal cancer is on the rise worldwide, and urgent countermeasures are required. The purpose of our study was to develop a comprehensive analysis system to elucidate the pharmacology and mechanism of chemopreventive candidates by recapitulating the carcinogenic stages of normal epithelium, adenoma, sessile serrated adenoma/polyp (SSA/P), and colorectal cancer using organoids, a novel culture technique. The aim of this study was to develop a system for comprehensive analysis of the pharmacology/mechanism of chemopreventive candidate drugs by recreating each carcinogenic stage of colorectal cancer with organoids. We established human-derived colonic organoids and created a cell bank. We also succeeded in transplanting them into mice using the Xenograft model. We investigated the synergistic effects and mechanisms of chemoprevention using aspirin and metformin.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では大腸癌の一次予防、なかでも化学予防（Chemoprevention）に着目して研究を進め、化学予防薬候補のアスピリン、メトホルミンの予防効果の機序解析を行った。
大腸癌の二次予防（早期発見、早期治療）は、これまで一定の成果を上げてはいるが、増加する大腸癌の罹患/死亡には対応しきれておらず、今後はより進んだ対策が求められている。そのため根本的な対策である一次予防（健康増進/疾病予防）が今後の大腸癌の罹患/死亡率の抑制や、高騰する医療費の抑制には、より重要となり、本研究の化学予防の取り組みはその一助となるものである。
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