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Evaluation of effect of improvement in blood glucose fluctuation during the day and endothelial function by Waon suit on stabilization of coronary plaque

Research Project

Project/Area Number 18K08044
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionWakayama Medical University

Principal Investigator

Ino Yasushi  和歌山県立医科大学, 医学部, 准教授 (00549793)

Co-Investigator(Kenkyū-buntansha) 久保 隆史  和歌山県立医科大学, 医学部, 博士研究員 (30316096)
嶋村 邦宏  和歌山県立医科大学, 医学部, 講師 (20584874)
赤阪 隆史  和歌山県立医科大学, 医学部, 博士研究員 (70322584)
亀山 剛義  東北医科薬科大学, 医学部, 講師 (50761847)
谷本 貴志  和歌山県立医科大学, 医学部, 准教授 (90438284)
Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords不安定プラーク / 冠動脈疾患 / 平均血糖変動幅 / 和温療法スーツ / 内皮機能障害 / プラーク安定化 / 簡易和温療法 / 血糖日内変動
Outline of Final Research Achievements

This study investigated the late vascular response after everolimus-eluting stent (EES) implantation assessed by optical coherence tomography (OCT) in acute myocardial infarction (AMI) patients due to calcified nodule (CN) by comparing with plaque rupture (PR) and plaque erosion (PE). In 10-month follow-up OCT, the frequency of uncovered struts and malapposed struts were highest in CN, followed by PR and PE. Furthermore, the incidence of intra-stent thrombus, re-appearance of CN within stent, and target lesion revascularization were higher in CN compared with PR and PE. Late arterial healing response at 10-month after EES implantation in CN was worse compared with PR and PE. These findings provide important information about treatment strategy in patients with AMI.

Academic Significance and Societal Importance of the Research Achievements

急性心筋梗塞の病因が石灰化結節であることが、遠隔期の薬剤溶出性ステント留置部の再狭窄や血栓症などのイベントにつながりうる遅延した血管治癒反応に関連する因子であることが明らかとなり、石灰化結節を病因とする急性心筋梗塞においては、ステント留置以外の治療を考慮すべきであることが示唆された。本研究は、石灰化結節を病因とする急性心筋梗塞に対する最適な再灌流治療ストラテジーを考慮する一助となり得る。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (12 results)

All 2023 2021 2020 2019

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 6 results) Presentation (1 results)

  • [Journal Article] Which is more useful for predicting no-reflow phenomenon? Insights from optical coherence tomography and coronary computed tomography.2023

    • Author(s)
      Ozaki Y, Taniguchi M, Katayama Y, Satogami K, Ino Y, Tanaka A.
    • Journal Title

      Cardiovasc Interv Ther.

      Volume: 38 Issue: 2 Pages: 246-247

    • DOI

      10.1007/s12928-022-00897-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Upper Arm Prolonged Occlusion on Radial Artery Diameter Before Coronary Angiography in Patients With Coronary Artery Disease2023

    • Author(s)
      Taniguchi Motoki、Ozaki Yuichi、Katayama Yosuke、Satogami Keisuke、Ino Yasushi、Tanaka Atsushi
    • Journal Title

      Cardiovascular Revascularization Medicine

      Volume: 51 Pages: 38-42

    • DOI

      10.1016/j.carrev.2023.01.017

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term risk stratification for hospitalized patients with acute heart failure at a single rural cardiovascular centre2023

    • Author(s)
      Satogami K, Katayama Y, Ozaki Y, Taruya A, Taniguchi M, Ota S, Kuroi A, Shiono Y, Tanimoto T, Yamano T, Kitabata H, Ino Y, Tanaka A.
    • Journal Title

      ESC Heart Failure

      Volume: 10 Issue: 3 Pages: 1717-1725

    • DOI

      10.1002/ehf2.14325

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of optical coherence tomography with angiographic coregistration in the guidance of coronary stent implantation2021

    • Author(s)
      Kubo Takashi、Ino Yasushi、Shiono Yasutsugu、Terada Kosei、Emori Hiroki、Higashioka Daisuke、Takahata Masahiro、Wada Teruaki、Shimamura Kunihiro、Khalifa Amir Kh. M.、Tu Shengxian、Akasaka Takashi
    • Journal Title

      Heart and Vessels

      Volume: 37 Issue: 2 Pages: 200-207

    • DOI

      10.1007/s00380-021-01911-1

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of left ventricular ejection fraction and preoperative hemoglobin level on perioperative adverse cardiovascular events in noncardiac surgery2021

    • Author(s)
      Sougawa Hiromichi、Ino Yasushi、Kitabata Hironori、Tanimoto Takashi、Takahata Masahiro、Shimamura Kunihiro、Shiono Yasutsugu、Yamaguchi Tomoyuki、Kuroi Akio、Ota Shingo、Taruya Akira、Takemoto Kazushi、Tanaka Atsushi、Kubo Takashi、Hozumi Takeshi、Akasaka Takashi
    • Journal Title

      Heart and Vessels

      Volume: 36 Issue: 9 Pages: 1317-1326

    • DOI

      10.1007/s00380-021-01818-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical coherence tomography detection of vulnerable plaques at high risk of developing acute coronary syndrome2021

    • Author(s)
      Kubo T, Ino Y, Mintz GS, Shiono Y, Shimamura K, Takahata M, Terada K, Higashioka D, Emori H, Wada T, Kashiwagi M, Tanimoto T, Tanaka A, Hozumi T, Akasaka T
    • Journal Title

      Eur Heart J Cardiovasc Imaging

      Volume: jeab028

    • DOI

      10.1093/ehjci/jeab028

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Target Lesion Lipid Content Detected by Near-Infrared Spectroscopy After Stenting and the Risk of Subsequent Target Lesion Failure2021

    • Author(s)
      Madder Ryan D.、Kubo Takashi、Ino Yasushi、Kameyama Takeyoshi、Terada Kosei、VanOosterhout Stacie、Mulder Abbey、McNamara Michael、Kenaan Mohamad、Samani Soroush、Kassier Adnan、Parker Jessica L.、McNamara Richard、Akasaka Takashi
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 41 Issue: 7 Pages: 2181-2189

    • DOI

      10.1161/atvbaha.120.315617

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Near-infrared spectroscopy to predict microvascular obstruction after primary percutaneous coronary intervention2021

    • Author(s)
      Terada Kosei、Kubo Takashi、Madder Ryan D.、Ino Yasushi、Takahata Masahiro、Shimamura Kunihiro、Shiono Yasutsugu、Nishi Takahiro、Emori Hiroki、Higashioka Daisuke、Khalifa Amir Kh. M.、Wada Teruaki、Akasaka Takashi
    • Journal Title

      EuroIntervention

      Volume: 17 Issue: 12 Pages: e999-e1006

    • DOI

      10.4244/eij-d-20-01421

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence, Features, and Prognosis of Artery‐to‐Artery Embolic ST‐Segment?Elevation Myocardial Infarction: An Optical Coherence Tomography Study2020

    • Author(s)
      Takahata Masahiro、Ino Yasushi、Kubo Takashi、Tanimoto Takashi、Taruya Akira、Terada Kosei、Emori Hiroki、Higashioka Daisuke、Katayama Yosuke、Khalifa Amir Kh. M.、Wada Teruaki、Ozaki Yuichi、Shimamura Kunihiro、Shiono Yasutsugu、Akasaka Takashi
    • Journal Title

      Journal of the American Heart Association

      Volume: 9 Issue: 24 Pages: 1-11

    • DOI

      10.1161/jaha.120.017661

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Very late phase vascular response after everolimus eluting stent implantation assessed by optical coherence tomography2020

    • Author(s)
      Khalifa AKM, Ino Y, Kubo T, Tanimoto T, Shimamura K, Shiono Y, Takahata M, Terada K, Higashioka D, Wada T, Taruya A, Emori H, Katayama Y, Kashiwagi M, Kuroi A, Matsuo Y, Fujita S, Tanaka A, Hozumi T, Akasaka T
    • Journal Title

      The International Journal of Cardiovascular Imaging

      Volume: 36 Issue: 9 Pages: 1627-1635

    • DOI

      10.1007/s10554-020-01877-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor2019

    • Author(s)
      Ino Y, Kubo T, Shimamura K, Takahata M, Matsuo Y, Kitabata H, Shiono Y, Wada T, Terada K, Katayama Y, Emori H, Higashioka D, Tanaka A, Hozumi T, Akasaka T
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 8 Pages: 1765

    • DOI

      10.1253/circj.CJ-18-0983

    • NAID

      130007682987

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-07-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Difference of Vascular Response after Everolimus-Eluting Stent among PlaqueRupture, Plaque Erosion, and Calcified Nodule Assessed by OCT2021

    • Author(s)
      Ino Y, et al.
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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